Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems

Panying Rong, Yana Yunusova, Jun Wang, Lorne Zinman, Gary L Pattee, James D Berry, Bridget Perry, Jordan R Green, Panying Rong, Yana Yunusova, Jun Wang, Lorne Zinman, Gary L Pattee, James D Berry, Bridget Perry, Jordan R Green

Abstract

Purpose: To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.

Method: Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.

Results: Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).

Conclusion: Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Flow chart for (1) the variable selection and dimensionality reduction for each subsystem; (2) constructing of individual subsystem models of speech intelligibility; and (3) development of a multi-subsystem model of speech intelligibility.
Fig 2. Scatter plots of intelligibility against…
Fig 2. Scatter plots of intelligibility against the estimated values of intelligibility based on each individual subsystem model.

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