A prospective study on neonatal mortality and its predictors in a rural area in Burkina Faso: can MDG-4 be met by 2015?

A H Diallo, N Meda, W T Ouédraogo, S Cousens, T Tylleskar, PROMISE-EBF Study Group, Thorkild Tylleskär, Philippe Van de Perre, Eva-Charlotte Ekström, Nicolas Meda, James K Tumwine, Chipepo Kankasa, Debra Jackson, Thorkild Tylleskär, Ingunn M S Engebretsen, Lars Thore Fadnes, Eli Fjeld, Knut Fylkesnes, Jørn Klungsøyr, Anne Nordrehaug, Øystein Evjen Olsen, Bjarne Robberstad, Halvor Sommerfelt, Philippe Van de Perre, Eva-Charlotte Ekström, Barni Nor, Nicolas Meda, Abdoulaye Hama Diallo, Thomas W Ouédraogo, Jeremi Rouamba, Bernadette Traoré, Germain Traoré, Emmanuel Zabsonré, James K Tumwine, Caleb Bwengye, Charles Karamagi, Victoria Nankabirwa, Jolly Nankunda, Grace Ndeezi, Margaret Wandera, Chipepo Kankasa, Mary Katepa-Bwalya, Seter Siziya, Debra Jackson, Mickey Chopra, Mark Colvin, Tanya Doherty, Ameena E Goga, Lungiswa Nkonki, David Sanders, Wesley Solomons, Wanga Zembe, A H Diallo, N Meda, W T Ouédraogo, S Cousens, T Tylleskar, PROMISE-EBF Study Group, Thorkild Tylleskär, Philippe Van de Perre, Eva-Charlotte Ekström, Nicolas Meda, James K Tumwine, Chipepo Kankasa, Debra Jackson, Thorkild Tylleskär, Ingunn M S Engebretsen, Lars Thore Fadnes, Eli Fjeld, Knut Fylkesnes, Jørn Klungsøyr, Anne Nordrehaug, Øystein Evjen Olsen, Bjarne Robberstad, Halvor Sommerfelt, Philippe Van de Perre, Eva-Charlotte Ekström, Barni Nor, Nicolas Meda, Abdoulaye Hama Diallo, Thomas W Ouédraogo, Jeremi Rouamba, Bernadette Traoré, Germain Traoré, Emmanuel Zabsonré, James K Tumwine, Caleb Bwengye, Charles Karamagi, Victoria Nankabirwa, Jolly Nankunda, Grace Ndeezi, Margaret Wandera, Chipepo Kankasa, Mary Katepa-Bwalya, Seter Siziya, Debra Jackson, Mickey Chopra, Mark Colvin, Tanya Doherty, Ameena E Goga, Lungiswa Nkonki, David Sanders, Wesley Solomons, Wanga Zembe

Abstract

Objective: To measure the neonatal mortality rate (NMR) and investigate its predictors in a rural area of Burkina Faso.

Study design: A cohort of infants born in 24 villages in Banfora region was followed until the children were 6 months old. We estimated the risk of neonatal death and used logistic regression to identify its predictors.

Result: Among 864 live births followed to day 28, there were 40 neonatal deaths, a NMR of 46.3 per 1000 live births (95% confidence intervals (CI): 22 to 70). Multivariable regression identified twin birth (OR=11.5, 95% CI: 4.5 to 29.8), having a nulliparous mother (odds ratio (OR)=4.3, 95% CI: 1.5 to 12.1), and birth into a polygynous household (OR=2.1, 95% CI: 1.0 to 4.7) as main predictors of neonatal death.

Conclusion: The burden of neonatal mortality in rural Burkina Faso is very high and the observed NMRs in a predominantly rural country suggest that it is unlikely Burkina will meet fourth Millennium Development Goal (MDG-4) by 2015.

References

    1. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010;375 (9730:1969–1987.
    1. Rajaratnam JK, Marcus JR, Flaxman AD, Wang H, Levin-Rector A, Dwyer L, et al. Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970–2010: a systematic analysis of progress towards Millennium Development Goal 4. Lancet. 2010;375 (9730:1988–2008.
    1. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? Where? Why. Lancet. 2005;365 (9462:891–900.
    1. Lawn JE, Kerber K, Enweronu-Laryea C, Massee Bateman O. Newborn survival in low resource settings—are we delivering. BJOG. 2009;116 (Suppl 1:49–59.
    1. Bhutta AZ, Chopra M, Axelson H, Berman P, Boerma JT, Bryce J, et al. Countdown to 2015 decade report (2000–10): taking stock of maternal, newborn, and child survival. Lancet. 2010;375:2032.
    1. UNICEF . The State of the World's Children: Celebrating 20 years of the Convention on the rights of the child. UNICEF: New York (USA); 2009.
    1. World Health Organization . Neonatal and Perinatal mortality: Country, Regional and Global estimates 2004. WHO: Geneva; 2007.
    1. Abdullah S, Adazu K, Masanja H, Diallo D, Hodgson A, Ilboudo-Sanogo E, et al. Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. Am J Trop Med Hyg. 2007;77 (6 Suppl:99–105.
    1. Ndugwa RP, Ramroth H, Muller O, Jasseh M, Sie A, Kouyate B, et al. Comparison of all-cause and malaria-specific mortality from two West African countries with different malaria transmission patterns. Malar J. 2008;7:15.
    1. Diallo DA, Cousens SN, Cuzin-Ouattara N, Nebie I, Ilboudo-Sanogo E, Esposito F. Child mortality in a West African population protected with insecticide-treated curtains for a period of up to 6 years. Bull World Health Organ. 2004;82 (2:85–91.
    1. Hammer GP, Kouyate B, Ramroth H, Becher H. Risk factors for childhood mortality in sub-Saharan Africa. A comparison of data from a Demographic and Health Survey and from a Demographic Surveillance System. Acta Trop. 2006;98 (3:212–218.
    1. Kynast-Wolf G, Sankoh OA, Gbangou A, Kouyate B, Becher H. Mortality patterns, 1993–98, in a rural area of Burkina Faso, West Africa, based on the Nouna demographic surveillance system. Trop Med Int Health. 2002;7 (4:349–356.
    1. Diallo DA, Habluetzel A, Esposito F, Cousens SN. Comparison of two methods for assessing child mortality in areas without comprehensive registration systems. Trans R Soc Trop Med Hyg. 1996;90 (6:610–613.
    1. Hammer GP, Some F, Muller O, Kynast-Wolf G, Kouyate B, Becher H. Pattern of cause-specific childhood mortality in a malaria endemic area of Burkina Faso. Malar J. 2006;5:47.
    1. Koueta F, Dao L, Ye D, Zoungrana A, Kabore A, Sawadogo A. Risk factors for death from severe malaria in children at the Charles de Gaulle pediatric hospital of Ouagadougou (Burkina Faso) Sante. 2007;17 (4:195–199.
    1. Koueta F, Ye D, Dao L, Neboua D, Sawadogo A. Neonatal morbidity and mortality in 2002–2006 at the Charles de Gaulle pediatric hospital in Ouagadougou (Burkina Faso) Sante. 2007;17 (4:187–191.
    1. Filippi V, Ganaba R, Baggaley RF, Marshall T, Storeng KT, Sombie I, et al. Health of women after severe obstetric complications in Burkina Faso: a longitudinal study. Lancet. 2007;370 (9595:1329–1337.
    1. Kabore P, Potvliege C, Sanou H, Bawhere P, Dramaix M. Growth velocity and survival of full-term low birth weight infants in an African rural area (Burkina Faso) Arch Pediatr. 2004;11 (7:807–814.
    1. Koueta F, Ye D, Dao L, Zoungrana-Kabore A, Ouedraogo SA, Napon M, et al. Lung disease and HIV infection in children at the Charles de Gaulle university pediatric hospital center in Ouagadougou (Burkina Faso) Sante. 2008;18 (1:15–18.
    1. Nankunda J, Tumwine JK, Soltvedt A, Semiyaga N, Ndeezi G, Tylleskar T. Community based peer counsellors for support of exclusive breastfeeding: experiences from rural Uganda. Int Breastfeed J. 2006;1:19.
    1. INSD MEF/Burkina Faso . Annuaire Statistique 2008 de la Region des Cascades (Statistics of the Cascades Region in 2008) MEF/INSD: Ouagadougou (Burkina Faso); 2008.
    1. INSD MEF/Burkina Faso . Recensement General de la Population et de l'Habitat, 2006 (General Population Census, 2006) MEF/INSD: Ouagadougou (Burkina Faso); 2009.
    1. Diallo AH, Meda N, Zabsonré E, Sommerfelt H, Cousens S, Tylleskar T. Perinatal mortality in rural Burkina Faso: a prospective community-based cohort study. BMC Pregnancy Childbirth. 2010;10 (45:1–9.
    1. Institut National de Statistique et de la Démographie (INSD) et ORC Macro . Enquête Démographique et de Santé du Burkina Faso 2003 (DHS) Calverton, Maryland (USA); 2004.
    1. World Health Organization . Standard neonatal verbal autopsy questionnaire Revised version. WHO Publications: Geneva (Switzerland); 2003.
    1. Winbo IG, Serenius FH, Dahlquist GG, Kallen BA. NICE, a new cause of death classification for stillbirths and neonatal deaths. Neonatal and Intrauterine Death Classification according to Etiology. Int J Epidemiol. 1998;27 (3:499–504.
    1. World Health Organization . International statistical classification of diseases and related health problem, 10th revision (ICD-10) WHO: Geneva; 2007.
    1. Kramer MS, Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2002. p. CD003517.
    1. Kolenikov S, Angeles G. Socioeconomic status measurement with discrete proxy variables: is principal component analysis a reliable answer. Rev Income and Wealth. 2009;Series 55 (March 2009:128.
    1. Mosley WH, Chen LC. An analytical framework for the study of child survival in developing countries. 1984. Bull World Health Organ. 2003;81 (2:140–145.
    1. Edmond KM, Kirkwood BR, Amenga-Etego S, Owusu-Agyei S, Hurt LS. Effect of early infant feeding practices on infection-specific neonatal mortality: an investigation of the causal links with observational data from rural Ghana. Am J Clin Nutr. 2007;86 (4:1126–1131.
    1. Lawn JE, Yakoob MY, Haws RA, Soomro T, Darmstadt GL, Bhutta ZA. 3.2 million stillbirths: epidemiology and overview of the evidence review. BMC Pregnancy Childbirth. 2009;9 (Suppl 1)::S2.
    1. Spector JM, Daga S. Preventing those so-called stillbirths. Bull World Health Organ. 2008;86 (4:315–316.
    1. Edmond KM, Quigley MA, Zandoh C, Danso S, Hurt C, Owusu Agyei S, et al. Aetiology of stillbirths and neonatal deaths in rural Ghana: implications for health programming in developing countries. Paediatr Perinat Epidemiol. 2008;22 (5:430–437.
    1. Direction des Etudes et de la Planification (DEP/MS) Annuaire Statistique Santé (Health Statistics Book)-Edition 2008. Official publication. Ouagadougou (Burkina Faso): MS/DEP; 2009.
    1. Graham WJ, Conombo SG, Zombre DS, Meda N, Byass P, De Brouwere V. Undertaking a complex evaluation of safe motherhood in rural Burkina Faso. Trop Med Int Health. 2008;13 (Suppl 1:1–5.
    1. Hounton S, Chapman G, Menten J, De Brouwere V, Ensor T, Sombie I, et al. Accessibility and utilisation of delivery care within a Skilled Care Initiative in rural Burkina Faso. Trop Med Int Health. 2008;13 (Suppl 1:44–52.
    1. Nikiema L, Kameli Y, Capon G, Sondo B, Martin-Prevel Y. Quality of antenatal care and obstetrical coverage in rural Burkina Faso. J Health Popul Nutr. 2010;28 (1:67–75.
    1. Benzler J, Sauerborn R. Rapid risk household screening by neonatal arm circumference: results from a cohort study in rural Burkina Faso. Trop Med Int Health. 1998;3 (12:962–974.
    1. Roberfroid D, Huybregts L, Lanou H, Henry MC, Meda N, Menten J, et al. Effects of maternal multiple micronutrient supplementation on fetal growth: a double-blind randomized controlled trial in rural Burkina Faso. Am J Clin Nutr. 2008;88 (5:1330–1340.
    1. Bryce J, Daelmans B, Dwivedi A, Fauveau V, Lawn JE, Mason E, et al. Countdown to 2015 for maternal, newborn, and child survival: the 2008 report on tracking coverage of interventions. Lancet. 2008;371 (9620:1247–1258.
    1. Bryce J, Gilroy K, Jones G, Hazel E, Black RE, Victora CG. The Accelerated Child Survival and Development programme in west Africa: a retrospective evaluation. Lancet. 2010;375 (9714:572–582.
    1. Haws RA, Yakoob MY, Soomro T, Menezes EV, Darmstadt GL, Bhutta ZA. Reducing stillbirths: screening and monitoring during pregnancy and labour. BMC Pregnancy Childbirth. 2009;9 (Suppl 1:S5.
    1. Steketee RW, Wirima JJ, Hightower AW, Slutsker L, Heymann DL, Breman JG. The effect of malaria and malaria prevention in pregnancy on offspring birthweight, prematurity, and intrauterine growth retardation in rural Malawi. Am J Trop Med Hyg. 1996;55 (1 Suppl:33–41.
    1. Amey FK. Polygyny and child survival in West Africa. Soc Biol. 2002;49 (1–2:74–89.
    1. Ukwuani AF, Cornwell TG, Suchindran MC. Polygyny and child survival in Nigeria: age-dependant effects. J Popul Res. 2002;19 (2:17.
    1. Gyimah SO. Polygynous marital structure and child survivorship in sub-Saharan Africa: some empirical evidence from Ghana. Soc Sci Med. 2009;68 (2:334–342.
    1. Strassmann BI. Polygyny as a risk factor for child mortality among the Dogon. Current Anthropology. 1997;38 (4:7.
    1. Jahn A, Kynast-Wolf G, Kouyate B, Becher H. Multiple pregnancy in rural Burkina Faso: frequency, survival, and use of health services. Acta Obstet Gynecol Scand. 2006;85 (1:26–32.
    1. Becher H, Muller O, Jahn A, Gbangou A, Kynast-Wolf G, Kouyate B. Risk factors of infant and child mortality in rural Burkina Faso. Bull World Health Organ. 2004;82 (4:265–273.
    1. Rutherford ME, Mulholland K, Hill PC. How access to health care relates to under-five mortality in sub-Saharan Africa: systematic review. Trop Med Int Health. 2010;15 (5:508–519.

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