Laparoscopic combined resection of liver metastases and colorectal cancer: a multicenter, case-matched study using propensity scores

M J van der Poel, P J Tanis, H A Marsman, A M Rijken, E C Gertsen, S Ovaere, M F Gerhards, M G Besselink, M D'Hondt, P D Gobardhan, M J van der Poel, P J Tanis, H A Marsman, A M Rijken, E C Gertsen, S Ovaere, M F Gerhards, M G Besselink, M D'Hondt, P D Gobardhan

Abstract

Background: Combined laparoscopic resection of liver metastases and colorectal cancer (LLCR) may hold benefits for selected patients but could increase complication rates. Previous studies have compared LLCR with liver resection alone. Propensity score-matched studies comparing LLCR with laparoscopic colorectal cancer resection (LCR) alone have not been performed.

Methods: A multicenter, case-matched study was performed comparing LLCR (2009-2016, 4 centers) with LCR alone (2009-2016, 2 centers). Patients were matched based on propensity scores in a 1:1 ratio. Propensity scores were calculated with the following preoperative variables: age, sex, ASA grade, neoadjuvant radiotherapy, type of colorectal resection and T and N stage of the primary tumor. Outcomes were compared using paired tests.

Results: Out of 1020 LCR and 64 LLCR procedures, 122 (2 × 61) patients could be matched. All 61 laparoscopic liver resections were minor hepatectomies, mostly because of a solitary liver metastasis (n = 44, 69%) of small size (≤ 3 cm) (n = 50, 78%). LLCR was associated with a modest increase in operative time [206 (166-308) vs. 197 (148-231) min, p = 0.057] and blood loss [200 (100-700) vs. 75 (5-200) ml, p = 0.011]. The rate of Clavien-Dindo grade 3 or higher complications [9 (15%) vs. 13 (21%), p = 0.418], anastomotic leakage [5 (8%) vs. 4 (7%), p = 1.0], conversion rate [3 (5%) vs. 5 (8%), p = 0.687] and 30-day mortality [0 vs. 1 (2%), p = 1.0] did not differ between LLCR and LCR.

Conclusion: In selected patients requiring minor hepatectomy, LLCR can be safely performed without increasing the risk of postoperative morbidity compared to LCR alone.

Keywords: Colorectal liver metastases; Colorectal resection; Laparoscopy; Liver resection; Simultaneous.

Conflict of interest statement

Drs. M.J. van der Poel, P.J. Tanis, H.A. Marsman, A.M. Rijken, E.C. Gertsen, S. Ovaere, M.F. Gerhards, prof. M.G. Besselink, M. D’Hondt, and P.D. Gobardhan have no conflicts of interest or financial ties to disclose.

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