The Sierra Leone Trial to Introduce a Vaccine Against Ebola: An Evaluation of rVSV∆G-ZEBOV-GP Vaccine Tolerability and Safety During the West Africa Ebola Outbreak

Mohamed Samai, Jane F Seward, Susan T Goldstein, Barbara E Mahon, Durodami Radcliffe Lisk, Marc-Alain Widdowson, Mohamed I Jalloh, Stephanie J Schrag, Ayesha Idriss, Rosalind J Carter, Peter Dawson, S A S Kargbo, Bailah Leigh, Mohamed Bawoh, Jennifer Legardy-Williams, Gibrilla Deen, Wendy Carr, Amy Callis, Robert Lindblad, James B W Russell, Carey R Petrie, Augustin E Fombah, Brima Kargbo, Wendi McDonald, Olamide D Jarrett, Robert E Walker, Paul Gargiullo, Donald Bash-Taqi, Laura Gibson, Abu Bakarr Fofanah, Anne Schuchat, STRIVE Study Team, Bailah Leigh, Kathleen Neuzil, Hazel Insip, George Risi, Samba Sow, Mohamed Samai, Jane F Seward, Susan T Goldstein, Barbara E Mahon, Durodami Radcliffe Lisk, Marc-Alain Widdowson, Mohamed I Jalloh, Stephanie J Schrag, Ayesha Idriss, Rosalind J Carter, Peter Dawson, S A S Kargbo, Bailah Leigh, Mohamed Bawoh, Jennifer Legardy-Williams, Gibrilla Deen, Wendy Carr, Amy Callis, Robert Lindblad, James B W Russell, Carey R Petrie, Augustin E Fombah, Brima Kargbo, Wendi McDonald, Olamide D Jarrett, Robert E Walker, Paul Gargiullo, Donald Bash-Taqi, Laura Gibson, Abu Bakarr Fofanah, Anne Schuchat, STRIVE Study Team, Bailah Leigh, Kathleen Neuzil, Hazel Insip, George Risi, Samba Sow

Abstract

ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].

Figures

Figure 1.
Figure 1.
Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) consort flow diagram. *More than 1 reason for ineligibility could be selected; the 6 most common reasons are listed. †A total of 4123 participants were vaccinated within 7 days; 42 were vaccinated after 7 days. ǂIncluded in the vaccinated group. §10 with invalid substudy consent; 3 other.
Figure 2.
Figure 2.
Map of Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) study sites, Sierra Leone. Abbreviation: CDC, Centers for Disease Control and Prevention.

Source: PubMed

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