Changes of recovery quality and early cognitive function after treatment of sevoflurane combined with propofol in the elderly undergoing cholecystectomy
Yading Shen, Yu Liu, Yandan Wu, Jie He, Yading Shen, Yu Liu, Yandan Wu, Jie He
Abstract
Objective: To explore the application value of sevoflurane + propofol in elderly patients undergoing cholecystectomy.
Methods: A total of 121 elderly patients undergoing cholecystectomy in our hospital from February 2017 to March 2020 were enrolled. Among them, 58 patients were assigned to Group A given, anesthesia with sevoflurane during operation, and 63 patients to Group B who were given anesthesia with sevoflurane + propofol during the operation. The Mini-Mental State Examination (MMSE) was adopted to evaluate the cognitive function of the two groups at 1 hour (T1), 3 hours (T2) and 12 hours (T3) after operation, and enzyme-linked immuno-sorbent assay (ELISA) was used to determine inflammatory factors. The incidence of postoperative adverse reactions was compared between the two groups.
Results: The heart rate (HR) of patients at T2 was significantly lower than that at T1 and T3, and their HR at T3 was lower than that at T1 (P<0.05). There were differences in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at different time points in each group (both P<0.001). The mean artistic pressure (MAP) of patients at T2 was significantly lower than that at T1 and T3, and their MAP at T3 was lower than that at T1 (P<0.05). Additionally, oxygen saturation (SpO2) of patients at T2 was also significantly lower than that at T1 and T3, and their SpO2 at T3 was lower than that at T1 (P<0.05). Moreover, Group B showed significantly lower levels of serum inflammatory factors than Group A at T2 and T3 (P<0.05), and also got greatly lower Observer Assessment of Sedation (OAA/S) scores than Group A (P<0.05).
Conclusion: Sevoflurane + propofol can effectively improve the recovery quality and cognitive function and reduce inflammation after cholecystectomy in the elderly, so it is worthy of clinical promotion.
Keywords: Elderly patients; cholecystectomy; early cognitive function; propofol; recovery quality; sevoflurane.
Conflict of interest statement
None.
AJTR Copyright © 2021.
Figures
Figure 2
HR andMAP. A. HR of…
Figure 2
HR andMAP. A. HR of Group A at T2 and T3 was markedly…
Figure 3
SpO 2 . SpO 2…
Figure 3
SpO 2 . SpO 2 at T2 declined markedly compared with that at…
Figure 4
Inflammatory factors. The levels of…
Figure 4
Inflammatory factors. The levels of TNF-α, IL-1β and IL-10 in Group B were…
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Figure 3
SpO 2 . SpO 2…
Figure 3
SpO 2 . SpO 2 at T2 declined markedly compared with that at…
Figure 4
Inflammatory factors. The levels of…
Figure 4
Inflammatory factors. The levels of TNF-α, IL-1β and IL-10 in Group B were…
- Effects of propofol or sevoflurane anesthesia on the perioperative inflammatory response, pulmonary function and cognitive function in patients receiving lung cancer resection.Tian HT, Duan XH, Yang YF, Wang Y, Bai QL, Zhang X. Tian HT, et al. Eur Rev Med Pharmacol Sci. 2017 Dec;21(23):5515-5522. doi: 10.26355/eurrev_201712_13943. Eur Rev Med Pharmacol Sci. 2017. PMID: 29243798
- Effects of sevoflurane inhalation anesthesia on cognitive and immune function in elderly patients after abdominal operation.Liang LQ, Jiao YQ, Guo SL. Liang LQ, et al. Eur Rev Med Pharmacol Sci. 2018 Dec;22(24):8932-8938. doi: 10.26355/eurrev_201812_16663. Eur Rev Med Pharmacol Sci. 2018. PMID: 30575937
- [Effect of Dexmedetomidine Combined with Propofol or Sevoflurane General Anesthesia on Stress and Postoperative Quality of Recovery(QoR-40) in Patients Undergoing Laparoscopic Surgery].Zhang YF, Li CS, Lu XH, Li L. Zhang YF, et al. Zhonghua Yi Xue Za Zhi. 2019 May 7;99(17):1302-1306. doi: 10.3760/cma.j.issn.0376-2491.2019.17.006. Zhonghua Yi Xue Za Zhi. 2019. PMID: 31091576 Clinical Trial. Chinese.
- [Effects of transcutaneous electrical acupoint stimulation on quality of recovery during early period after laparoscopic cholecystectomy].Mi Z, Gao J, Chen X, Ge Y, Lu K. Mi Z, et al. Zhongguo Zhen Jiu. 2018 Mar 12;38(3):256-60. doi: 10.13703/j.0255-2930.2018.03.007. Zhongguo Zhen Jiu. 2018. PMID: 29701042 Clinical Trial. Chinese.
- Effects of sevoflurane inhalation anesthesia on IL-6, TNF-α and MMP-9 expression and hemodynamics in elderly patients undergoing lobectomy for lung cancer.Chen X, Li M, Zheng R, Huang Q, Li Y, Zhu Y, Chen Z, Lin J. Chen X, et al. Cell Mol Biol (Noisy-le-grand). 2020 Jul 31;66(5):49-53. Cell Mol Biol (Noisy-le-grand). 2020. PMID: 33040813
- Full Text Sources
- Medical
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