Efficacy of intralesional injections of platelet-rich plasma in patients with oral lichen planus: A pilot randomized clinical trial

AbdelHameed Hijazi, Wesam Ahmed, Soheir Gaafar, AbdelHameed Hijazi, Wesam Ahmed, Soheir Gaafar

Abstract

Objective: To evaluate the clinical efficacy of intralesional platelet-rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP).

Material and methods: Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded.

Results: Both groups showed significant improvement in the clinical parameters (pain and clinical score) "p = .001." Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission.

Conclusions: PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368.

Keywords: intralesional injections; oral lichen planus; platelet rich plasma.

Conflict of interest statement

The authors declare no conflict of interest.

© 2022 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.

Figures

Figure 1
Figure 1
Bar chart representing gender distribution frequency for different groups
Figure 2
Figure 2
Line graph shows mean pain score change in both groups during the study period
Figure 3
Figure 3
Line graph shows mean clinical score change in both groups during the study period
Figure 4
Figure 4
(a) A clinical photo showing irregular erosion affecting left buccal mucosa surrounded with white interlacing keratotic lesion resembling Wickham Striae. (b) After 3 weeks of treatment with intralesional platelet‐rich plasma (PRP) injections, the lesion shows complete remission with mild keratotic striae. (c) After 17 weeks of follow‐up, the lesion in remission
Figure 5
Figure 5
(a) A clinical photo showing irregular erosion affecting left buccal mucosa surrounded with white interlacing keratotic lesion resembling Wickham Striae and hyperpigmented mucosa. (b) After 3 weeks of treatment with intralesional triamcinolone acetonide (TA) injections, the lesion shows complete remission with keratotic striae. (c) After 17 weeks of follow‐up, the lesion still in remission

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