High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion

Jie Li, James B Fink, Stephan Ehrmann, Jie Li, James B Fink, Stephan Ehrmann

Abstract

Bio-aerosol dispersion via high-flow nasal cannula shows a similar risk to standard oxygen masks. High-flow nasal prongs with a surgical mask on the patient's face might benefit hypoxaemic COVID-19 patients without added risk for the environment. https://bit.ly/34p7Fyy

Conflict of interest statement

Conflict of interest: J. Li has nothing to disclose. Conflict of interest: J.B. Fink is the Chief Science Officer of Aerogen Pharma Corp. Conflict of interest: S. Ehrmann reports grants, personal fees and non-financial support from Fisher and Paykel, during the conduct of the study; grants, personal fees and non-financial support from Aerogen Ltd, personal fees and non-financial support from La diffusion technique française, grants from Hamilton medical, outside the submitted work.

References

    1. Ong SWX, Tan YK, Chia PY, et al. . Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA 2020; 323: 1610–1612. 10.1001/jama.2020.3227.
    1. Rochwerg B, Granton D, Wang DX, et al. . High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019; 45: 563–572. 10.1007/s00134-019-05590-5.
    1. Li J, Jing G, Scott JB. Year in review 2019: high-flow nasal cannula oxygen therapy for adult patients. Respir Care 2020; 65: 545–557. doi:10.4187/respcare.07663
    1. Arentz M, Yim E, Klaff L, et al. . Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA 2020; 323: 1612–1614. 10.1001/jama.2020.4326.
    1. Yang X, Yu Y, Xu J, et al. . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020; in press [10.1016/S2213-2600(20)30079-5].
    1. Hui DS, Chow BK, Lo T, et al. . Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks. Eur Respir J 2019; 53: 1802339. doi:10.1183/13993003.02339-2018
    1. Ip M, Tang JW, Hui DS, et al. . Airflow and droplet spreading around oxygen masks: a simulation model for infection control research. Am J Infect Control 2007; 35: 684–689. doi:10.1016/j.ajic.2007.05.007
    1. Leung CCH, Joynt GM, Gomersall CD, et al. . Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial. J Hosp Infect 2019; 101: 84–87. doi:10.1016/j.jhin.2018.10.007
    1. Hui DS, Chow BK, Chu L, et al. . Exhaled air dispersion during coughing with and without wearing a surgical or N95 mask. PLoS One 2012; 7: e50845. doi:10.1371/journal.pone.0050845
    1. Johnson DF, Druce JD, Birch C, et al. . A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection. Clin Infect Dis 2009; 49: 275–277. doi:10.1086/600041

Source: PubMed

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