A Consensus of Key Opinion Leaders on the Management of Pre-diabetes in the Asia-Pacific Region

Roberto Mirasol, Ah Chuan Thai, Aftab Ahmad Salahuddin, Kathryn Tan, Chaicharn Deerochanawong, Mafauzy Mohamed, Made Ratna Saraswati, Bipin Kumar Sethi, Sanjiv Shah, Nanny Natalia Soetedjo, Swangjit Suraamornkul, Rima Tan, Farid Uddin, Roberto Mirasol, Ah Chuan Thai, Aftab Ahmad Salahuddin, Kathryn Tan, Chaicharn Deerochanawong, Mafauzy Mohamed, Made Ratna Saraswati, Bipin Kumar Sethi, Sanjiv Shah, Nanny Natalia Soetedjo, Swangjit Suraamornkul, Rima Tan, Farid Uddin

Abstract

The Asia-Pacific region carries a high disease burden, with over half of the global diabetic population residing in this region. Increasing evidence shows that without targeted intervention, the progression from impaired glucose tolerance (IGT) to type 2 diabetes occurs more frequently in Asians compared with Caucasians. Furthermore, IGT is independently associated with an increased risk of cardiovascular disease, and should be managed as early as possible. Because diabetes is now a major public health issue, strategies aimed at prevention and treatment are urgently required. Lifestyle modification, including weight loss, dietary changes and increased physical activity, play a major role in controlling the disease. Significant evidence also supports the effectiveness of a combination of lifestyle modification and pharmacologic therapy, such as metformin, in delaying the onset of diabetes. Although the importance of lifestyle interventions is well recognized throughout Asia, many countries do not have formal recommendations to guide the diagnosis and management of individuals at risk of progression to diabetes. At a recent regional meeting, experts from the Asian region convened to develop consensus recommendations to guide clinicians in the management of Asian patients with pre-diabetes. These consensus recommendations provide a clear and concise approach to the management of individuals with IGT based on the available evidence and current best clinical practice.

Keywords: Asia; impaired glucose tolerance; pre-diabetes.

Conflict of interest statement

The authors have received honoraria for their participation in the APAC Regional Pre-Diabetes Advisory Board Meeting 2014. Professor Mirasol is an advisory board and speaker for AstraZeneca, Merck, Novo, Genzyme, Lilly, MSD.

© 2017 Journal of the ASEAN Federation of Endocrine Societies.

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