Immunopathology Technician II

Charles River Laboratories International Inc (CRL)

Durham, NC, US, 27703

JOB SUMMARY

Generate and record data in the performance of basic to moderately complex tasks associated with or in support of immunopathology laboratory procedures. Responsible for handling and processing samples, and performing accurate data collection and reporting.  Provide guidance and mentorship to less experienced staff. 

ESSENTIAL DUTIES AND RESPONSIBILITIES:   

  • Perform basic to moderately complex tasks associated with or in support of immunopathology laboratory procedures and collect and record/document research data in compliance with Good Laboratory Practices (GLPs), Standard Operating Procedures (SOPs), study protocols and company policies/practices. 
  • Handle unfixed human and animal tissues (e.g. preparation of frozen OCT-embedded tissue blocks and cryotomy). 
  • Perform dilution calculations, basic chemistry, and limited problem solving. 
  • Ensure the use of appropriate positive/negative tissue controls; fixations, staining procedures/techniques, and solution preparation. 
  • Input, print and edit computer entries (e.g., laboratory data). 
  • Receive samples and complete tracking documentation.  
  • Review documentation of functions performed as part of quality control requirements. 
  • Perform study preparation activities including sample labeling, equipment verifications, identifying supply needs, and working with study personnel to develop and implement study specific procedures (as appropriate).  
  • Perform more difficult/strenuous immunopathology tasks (e.g. high volume staining, simultaneous staining of different procedures, high volume cryotomy, precomplexes, and/or cross-reactivity staining, etc.) 
  • May work with hazardous materials in biosafety cabinet as needed (e.g. immunotoxin conjugated test materials) 
  • May assist with reviewing and updating processes and SOPs as assigned.  
  • May participate in sponsor representative interactions under the direct supervision of senior scientific staff or management. 
  • Maintain clean work areas.  
  • Perform all other related duties as assigned. 

JOB QUALIFICATIONS

Education:  Bachelor’s degree (B.A. / B.S) or equivalent relevant experience in laboratory science or related discipline required. 

Experience:  Two or more years related experience in biology, chemistry/pharmacy, or similar lab environment; GLP experience preferred.   

Other:  Knowledge of GLPs and other federal regulations and guidelines. Attention to detail and accuracy a must.  Must be able to communicate effectively with management, coworkers and sponsors.  Basic Microsoft Office skills are required.  Understanding of mathematical concepts preferred.  

An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above. 

PHYSICAL DEMANDS: 

  • Must be able to remain in a stationary position 50% of the time while performing laboratory tasks. 
  • Frequently required to walk, sit, stand, reach with hands and arms, and use hands to finger, handle, or feel objects, tools, or controls in a repetitive manner. 
  • Regularly operate a computer and other office productivity machinery, such as a calculator, copy machine, and computer printer. 
  • Regularly uses close vision and the ability to adjust focus and detect and differentiate colors. 
  • Must regularly communicate with employees/customers; must be able to exchange accurate information. 
  • Employees must be able to lift, move, manipulate, and/or hold heavy objects up to and including 40 pounds occasionally; this includes work materials, equipment, and/or supplies. 
  • Must be able to wear safety equipment (PPE) according to OSHA regulations and company standards.   

WORK ENVIRONMENT:

  • General laboratory working conditions. 
  • May work in a chemical fume hood. 
  • May work with sharp objects. 
  • Regularly wears protective clothing (gloves, lab coat, and safety glasses). 
  • Regularly works with or near toxic or caustic chemicals. 
  • Regularly works with biohazards. 
  • The noise level in the work environment is usually low to moderate. 

COMMENTS:  

  • This position requires overtime, weekend, holiday, and/or after hours shift coverage, as needed. 

About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.

About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

Job posted: 2024-05-07

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