Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation (AA-IPRF-PDDG)
2026. október 31. frissítette: Mahmoud Ebrahim Ahmed Elsaadawy, Nahda University
Effect of Ascorbic Acid-Loaded Injectable Platelet-Rich Fibrin Combined With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
The study will investigate whether adding vitamin C to a mixture of tooth particles and a material prepared from the participant's own blood helps preserve the jawbone and improve bone healing.
The main questions it aims to answer are
- Does adding vitamin C help preserve the width of the jawbone after tooth extraction?
- Does it improve new bone formation compared with the other treatments?
Researchers will compare three treatments to determine whether adding a blood-based material, with or without vitamin C, improves bone preservation.
- The first group will receive small particles prepared from their own extracted tooth.
- The second group will receive tooth particles mixed with a healing material prepared from their own blood.
- The third group will receive tooth particles mixed with the same blood-based material containing vitamin C.
Participants will undergo tooth extraction and receive one of these treatments. They will attend follow-up visits during the healing period.
Researchers will:
- Examine the treated area during follow-up visits.
- Take three-dimensional dental scans before treatment and four months later to measure changes in jawbone width and height.
- Collect a small bone sample during dental implant placement to examine new bone formation and healing.
The study will help determine whether adding vitamin C to the blood-based material provides additional benefits for preserving the jawbone before dental implant placement.
A tanulmány áttekintése
Állapot
Még nincs toborzás
Körülmények
Részletes leírás
This study evaluates approaches to preserve the alveolar ridge following tooth extraction before delayed dental implant placement.
The study uses a partially demineralized dentin graft prepared from the participant's extracted tooth as the grafting material. It also investigates whether combining this graft with injectable platelet-rich fibrin (I-PRF), with or without added ascorbic acid (vitamin C), may influence bone healing and ridge preservation.
The rationale for using dentin is based on its potential as an autologous graft material. I-PRF provides an autologous blood-derived component. The addition of vitamin C is being investigated as a possible way to influence the healing response.
The study will assess changes in alveolar ridge dimensions and examine bone tissue collected during implant placement. Histological and histomorphometric analysis will help characterize new bone formation, residual graft material, and connective tissue within the healing site.
The findings may provide information about the role of vitamin C-enriched I-PRF when combined with autogenous dentin grafts for alveolar ridge preservation.
Tanulmány típusa
Beavatkozó
Beiratkozás (Becsült)
48
Fázis
- Nem alkalmazható
Kapcsolatok és helyek
Ez a rész a vizsgálatot végzők elérhetőségeit, valamint a vizsgálat lefolytatásának helyére vonatkozó információkat tartalmazza.
Tanulmányi kapcsolat
- Név: Mahmoud Ebrahim El-Saadawy, BDS
- Telefonszám: +201000559354
- E-mail: mahmoudelsaadawy061293@gmail.com
Tanulmányozza a kapcsolattartók biztonsági mentését
- Név: Mahmoud Ebrahim EL-Saadawy, BDS
- Telefonszám: +201007258261
- E-mail: mahmoudelsaadawy1993@gmail.com
Részvételi kritériumok
A kutatók olyan embereket keresnek, akik megfelelnek egy bizonyos leírásnak, az úgynevezett jogosultsági kritériumoknak. Néhány példa ezekre a kritériumokra a személy általános egészségi állapota vagy a korábbi kezelések.
Jogosultsági kritériumok
Tanulmányozható életkorok
18 év (Felnőtt)
Egészséges önkénteseket fogad
Igen
Tanulmányozható nemek
Összes
Leírás
Inclusion Criteria:
- Patients aged 18-60 years. ⁴⁷
- ASA Type I medically healthy patients with no significant medical history. ⁴⁷
- Non-restorable teeth indicated for extraction followed by delayed implant placement. ⁴⁸
- Patients eligible for immediate implant placement but facing factors that prevent implant placement at the time of extraction. ⁴⁸
- Patients requiring alveolar ridge preservation before planned dental implant placement.
- Presence of ST IB sockets after extraction. ⁴²-⁴⁴
- periodontally healthy adjacent teeth. ⁴⁸
- Adequate oral hygiene plaque index ≤15% and willingness to comply with the study protocol and follow-up visits. ⁴⁷
- Cooperative patients willing to comply with the 4-month follow-up period. ⁴⁷
- Ability to understand and sign the informed consent form. ⁴⁷
Exclusion Criteria:
- Uncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus).
- History of radiotherapy or chemotherapy involving the head and neck region.
- Current use of medications known to influence bone metabolism (e.g., bisphosphonates, denosumab, long-term corticosteroids).
- Smokers or tobacco users.
- Pregnancy or lactation.
- Acute uncontrolled infection extraction site.
- Patients with poor oral hygiene or untreated active periodontal disease.
- Psychiatric patients, or those with a learning disability, or those unable to give consent
- Patients unable or unwilling to attend follow-up visits.
Tanulási terv
Ez a rész a vizsgálati terv részleteit tartalmazza, beleértve a vizsgálat megtervezését és a vizsgálat mérését.
Hogyan készül a tanulmány?
Tervezési részletek
- Elsődleges cél: Kezelés
- Kiosztás: Véletlenszerűsített
- Beavatkozó modell: Párhuzamos hozzárendelés
- Maszkolás: Egyetlen
Fegyverek és beavatkozások
Résztvevő csoport / kar |
Beavatkozás / kezelés |
|---|---|
|
Aktív összehasonlító: Partially Demineralized Dentin Graft Alone
Participants will undergo alveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added. |
Alveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added. |
|
Kísérleti: Partially Demineralized Dentin Graft Combined with I-PRF
Participants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting mixture, referred to as Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
Alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting sticky dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
|
Kísérleti: Ascorbic Acid-Loaded I-PRF Combined with PDDG
Participants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting mixture, referred to as AA-Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
Alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting AA-Sticky Dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
Mit mér a tanulmány?
Elsődleges eredményintézkedések
Eredménymérő |
Intézkedés leírása |
Időkeret |
|---|---|---|
|
Change in Radiographic Horizontal Alveolar Ridge Width
Időkeret: Baseline (before alveolar ridge preservation) to 4 months postoperatively.
|
The change in horizontal alveolar ridge width will be assessed using cone-beam computed tomography (CBCT) scans obtained at baseline before alveolar ridge preservation and 4 months postoperatively. Measurements will be performed at the extraction site using standardized anatomical reference points and consistent measurement procedures. The change in ridge width from baseline to 4 months will be compared among the three study groups. |
Baseline (before alveolar ridge preservation) to 4 months postoperatively.
|
Másodlagos eredményintézkedések
Eredménymérő |
Intézkedés leírása |
Időkeret |
|---|---|---|
|
Histomorphometric Analysis of Core Bone Biopsy Specimens
Időkeret: 4 months after alveolar ridge preservation, during implant osteotomy. 4 months after alveolar ridge preservation, during implant osteotomy.
|
Histomorphometric analysis will be performed on core bone biopsy specimens collected from the alveolar ridge preservation sites during implant osteotomy 4 months postoperatively. The analysis will assess the percentages of newly formed bone, mature bone, and residual dentin graft particles in the specimens, and the results will be compared among the three study groups. |
4 months after alveolar ridge preservation, during implant osteotomy. 4 months after alveolar ridge preservation, during implant osteotomy.
|
Együttműködők és nyomozók
Itt találhatja meg a tanulmányban érintett személyeket és szervezeteket.
Szponzor
Nyomozók
- Tanulmányi szék: Mohamed Sherif EL-Mofty, Professor, Faculty of Dentistry, Nahda University Beni-Suef, Egypt.
- Tanulmányi igazgató: Shaimaa Hamdy Abd El-Azeem, : Department of Oral Medicine, Diagnosis and Periodontology, Faculty of Dentistry, Nahda University Beni-Suef, Egypt.
Publikációk és hasznos linkek
A vizsgálattal kapcsolatos információk beviteléért felelős személy önkéntesen bocsátja rendelkezésre ezeket a kiadványokat. Ezek bármiről szólhatnak, ami a tanulmányhoz kapcsolódik.
Általános kiadványok
- Tonetti MS, Jung RE, Avila-Ortiz G, Blanco J, Cosyn J, Fickl S, Figuero E, Goldstein M, Graziani F, Madianos P, Molina A, Nart J, Salvi GE, Sanz-Martin I, Thoma D, Van Assche N, Vignoletti F. Management of the extraction socket and timing of implant placement: Consensus report and clinical recommendations of group 3 of the XV European Workshop in Periodontology. J Clin Periodontol. 2019 Jun;46 Suppl 21:183-194. doi: 10.1111/jcpe.13131.
- Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017 Nov;21(8):2619-2627. doi: 10.1007/s00784-017-2063-9. Epub 2017 Feb 2.
- Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007 Feb;19(1):117-28, vii. doi: 10.1016/j.coms.2006.11.013.
- Santos A, Botelho J, Machado V, Borrecho G, Proenca L, Mendes JJ, Mascarenhas P, Alcoforado G. Autogenous Mineralized Dentin versus Xenograft granules in Ridge Preservation for Delayed Implantation in Post-extraction Sites: A Randomized controlled clinical trial with an 18 months follow-up. Clin Oral Implants Res. 2021 Aug;32(8):905-915. doi: 10.1111/clr.13765. Epub 2021 Jun 17.
- Abou Sulaiman AE, Shehadeh RM. Assessment of total antioxidant capacity and the use of vitamin C in the treatment of non-smokers with chronic periodontitis. J Periodontol. 2010 Nov;81(11):1547-54. doi: 10.1902/jop.2010.100173. Epub 2010 Jun 22.
- Elian N, Cho SC, Froum S, Smith RB, Tarnow DP. A simplified socket classification and repair technique. Pract Proced Aesthet Dent. 2007 Mar;19(2):99-104; quiz 106.
- Elbehwashy MT, Hosny MM, Elfana A, Nawar A, Fawzy El-Sayed K. Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial. Clin Oral Investig. 2021 Nov;25(11):6309-6319. doi: 10.1007/s00784-021-03929-1. Epub 2021 Apr 12.
- Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2018 Feb;44(1):87-95. doi: 10.1007/s00068-017-0767-9. Epub 2017 Mar 10.
- Corning PJ, Mealey BL. Ridge preservation following tooth extraction using mineralized freeze-dried bone allograft compared to mineralized solvent-dehydrated bone allograft: A randomized controlled clinical trial. J Periodontol. 2019 Feb;90(2):126-133. doi: 10.1002/JPER.18-0199. Epub 2018 Sep 19.
- Demetter RS, Calahan BG, Mealey BL. Histologic Evaluation of Wound Healing After Ridge Preservation With Cortical, Cancellous, and Combined Cortico-Cancellous Freeze-Dried Bone Allograft: A Randomized Controlled Clinical Trial. J Periodontol. 2017 Sep;88(9):860-868. doi: 10.1902/jop.2017.170155. Epub 2017 Apr 28.
- Elfana A, El-Kholy S, Saleh HA, Fawzy El-Sayed K. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021 May;32(5):539-548. doi: 10.1111/clr.13722. Epub 2021 Mar 1.
- van Orten A, Goetz W, Bilhan H. Tooth-Derived Granules in Combination with Platelet-Rich Fibrin ("Sticky Tooth") in Socket Preservation: A Histological Evaluation. Dent J (Basel). 2022 Feb 16;10(2):29. doi: 10.3390/dj10020029.
- Ben Amara H, Kim JJ, Kim HY, Lee J, Song HY, Koo KT. Is ridge preservation effective in the extraction sockets of periodontally compromised teeth? A randomized controlled trial. J Clin Periodontol. 2021 Mar;48(3):464-477. doi: 10.1111/jcpe.13412. Epub 2021 Jan 19.
- Barootchi S, Tavelli L, Majzoub J, Stefanini M, Wang HL, Avila-Ortiz G. Alveolar ridge preservation: Complications and cost-effectiveness. Periodontol 2000. 2023 Jun;92(1):235-262. doi: 10.1111/prd.12469. Epub 2022 Dec 29.
- Yang F, Ruan Y, Bai X, Li Q, Tang X, Chen J, Chen Y, Wang L. Alveolar ridge preservation in sockets with severe periodontal destruction using autogenous partially demineralized dentin matrix: A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Dec;25(6):1019-1032. doi: 10.1111/cid.13247. Epub 2023 Jul 16.
- Mardas N, Trullenque-Eriksson A, MacBeth N, Petrie A, Donos N. Does ridge preservation following tooth extraction improve implant treatment outcomes: a systematic review: Group 4: Therapeutic concepts & methods. Clin Oral Implants Res. 2015 Sep;26 Suppl 11:180-201. doi: 10.1111/clr.12639. Epub 2015 Jun 16.
- Couso-Queiruga E, Stuhr S, Tattan M, Chambrone L, Avila-Ortiz G. Post-extraction dimensional changes: A systematic review and meta-analysis. J Clin Periodontol. 2021 Jan;48(1):126-144. doi: 10.1111/jcpe.13390. Epub 2020 Nov 4.
- Sherif MA, Anter E, Graetz C, El-Sayed KF. Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2025 May 23;25(1):772. doi: 10.1186/s12903-025-06115-x.
- Steigmann L, Di Gianfilippo R, Steigmann M, Wang HL. Classification Based on Extraction Socket Buccal Bone Morphology and Related Treatment Decision Tree. Materials (Basel). 2022 Jan 19;15(3):733. doi: 10.3390/ma15030733.
- Fawzy El-Sayed KM, Nguyen N, Dorfer CE. Ascorbic Acid, Inflammatory Cytokines (IL-1beta/TNF-alpha/IFN-gamma), or Their Combination's Effect on Stemness, Proliferation, and Differentiation of Gingival Mesenchymal Stem/Progenitor Cells. Stem Cells Int. 2020 Aug 17;2020:8897138. doi: 10.1155/2020/8897138. eCollection 2020.
- Heimes D, Schiegnitz E, Kuchen R, Kammerer PW, Al-Nawas B. Buccal Bone Thickness in Anterior and Posterior Teeth-A Systematic Review. Healthcare (Basel). 2021 Nov 30;9(12):1663. doi: 10.3390/healthcare9121663.
- Castells-Mira E, Sanchez-Benito F, Alminana-Pastor PJ, Lopez-Roldan A. Radiographic and histomorphometric evaluation of Autogenous Particulated Dentin for Alveolar Ridge Preservation: A Systematic Review and Meta-analyses. J Clin Exp Dent. 2025 Oct 17;17(11):e1404-e1421. doi: 10.4317/jced.63147. eCollection 2025 Oct.
- Alrmali A, Saleh MHA, Mazzocco J, Zimmer JM, Testori T, Wang HL. Auto-dentin platelet-rich fibrin matrix is an alternative biomaterial for different augmentation procedures: A retrospective case series report. Clin Exp Dent Res. 2023 Dec;9(6):993-1004. doi: 10.1002/cre2.808. Epub 2023 Nov 7.
- Tada A, Miura H. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int J Environ Res Public Health. 2019 Jul 11;16(14):2472. doi: 10.3390/ijerph16142472.
- Um IW, Kim YK, Mitsugi M. Demineralized dentin matrix scaffolds for alveolar bone engineering. J Indian Prosthodont Soc. 2017 Apr-Jun;17(2):120-127. doi: 10.4103/jips.jips_62_17.
- Bertoldi C, Generali L, Cortellini P, Lalla M, Luppi S, Tomasi A, Zaffe D, Salvatori R, Bergamini S. Influence of Tooth-Brushing on Early Healing after Access Flap Surgery: A Randomized Controlled Preliminary Study. Materials (Basel). 2021 May 29;14(11):2933. doi: 10.3390/ma14112933.
- Zhou LL, Yuan W, Zhang X, Chen L, Graetz C. Alveolar Ridge Preservation in Posterior Extraction Sockets: A Literature Review and Proposal of a Novel Therapeutic Classification. Clin Cosmet Investig Dent. 2026 Mar 20;18:584600. doi: 10.2147/CCIDE.S584600. eCollection 2026.
- 1. Melek L, Marwan ES. 2016. Evaluation of "Autogenous Bioengineered Injectable PRF-Tooth Graft" Combination (ABIT) in Reconstruction of Maxillary Alveolar Ridge Defects. Saudi J Dent Res. 8:86-96.
- Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingstrom P, Campus G. The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Feb 3;17(3):938. doi: 10.3390/ijerph17030938.
- Binderman I, Hallel G, Nardy C, Yaffe A, Sapoznikov L. A novel procedure to process extracted teeth for immediate grafting of autogenous dentin. J Interdiscip Med Dent Sci. 2014;2:154.
- Mani A, Mani S, Sachdeva S, Sodhi JK, Vora HR, Gholap S. 2021. Post-Surgical Care in Surgical Periodontics. Int J Periodontol Implantol. 6:74-78.
- Alazzawi A, Ghazi M, Jikia M. 2018. Complications During and After Extraction of Third Molar. Caucasus J Health Sci Public Health. 2(2):28-31..
- El-Sioufi I, Oikonomou I, Koletsi D, Bobetsis YA, Madianos PN, Vassilopoulos S. Clinical evaluation of different alveolar ridge preservation techniques after tooth extraction: a randomized clinical trial. Clin Oral Investig. 2023 Aug;27(8):4471-4480. doi: 10.1007/s00784-023-05068-1. Epub 2023 May 25.
- Abaza G, Abdel Gaber HK, Afifi NS, Adel-Khattab D. Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled clinical trial with histomorphometric analysis. Clin Implant Dent Relat Res. 2024 Feb;26(1):88-102. doi: 10.1111/cid.13289. Epub 2023 Oct 31.
- Avila G, Galindo-Moreno P, Soehren S, Misch CE, Morelli T, Wang HL. A novel decision-making process for tooth retention or extraction. J Periodontol. 2009 Mar;80(3):476-91. doi: 10.1902/jop.2009.080454.
- Stumbras A, Januzis G, Gervickas A, Kubilius R, Juodzbalys G. Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in Growth Factors. J Oral Implantol. 2020 Oct 1;46(5):515-525. doi: 10.1563/aaid-joi-D-19-00179.
- Morton D, Wismeijer D, Chen S, Hamilton A, Wittneben J, Casentini P, Gonzaga L, Lazarin R, Martin W, Molinero-Mourelle P, Obermailer B, Polido WD, Tahmaseb A, Thoma D, Zembic A. Group 5 ITI Consensus Report: Implant placement and loading protocols. Clin Oral Implants Res. 2023 Sep;34 Suppl 26:349-356. doi: 10.1111/clr.14137.
- Yang Y, Wang T, Zhang S, Jia S, Chen H, Duan Y, Wang S, Chen G, Tian W. Vitamin C alleviates the senescence of periodontal ligament stem cells through inhibition of Notch3 during long-term culture. J Cell Physiol. 2021 Feb;236(2):1237-1251. doi: 10.1002/jcp.29930. Epub 2020 Jul 13.
- Sarkar N, Morton H, Bose S. Effects of vitamin C on osteoblast proliferation and osteosarcoma inhibition using plasma coated hydroxyapatite on titanium implants. Surf Coat Technol. 2020 Jul 25;394:125793. doi: 10.1016/j.surfcoat.2020.125793. Epub 2020 Apr 15.
- Van Pham P, Tran NY, Phan NL, Vu NB, Phan NK. Vitamin C stimulates human gingival stem cell proliferation and expression of pluripotent markers. In Vitro Cell Dev Biol Anim. 2016 Feb;52(2):218-27. doi: 10.1007/s11626-015-9963-2. Epub 2015 Oct 20.
- Van der Velden U. Vitamin C and Its Role in Periodontal Diseases - The Past and the Present: A Narrative Review. Oral Health Prev Dent. 2020 Apr 3;18(2):115-124. doi: 10.3290/j.ohpd.a44306.
- Fawzy El-Sayed KM, Cosgarea R, Sculean A, Doerfer C. Can vitamins improve periodontal wound healing/regeneration? Periodontol 2000. 2024 Feb;94(1):539-602. doi: 10.1111/prd.12513. Epub 2023 Aug 17.
- Gowda TM, Jayashri M, Venkatesh UG, Shah R, Kumar ABT, Deepthi M, Priya S. Autologous tooth bone graft block compared with advanced platelet-rich fibrin in alveolar ridge preservation: A clinico-radiographic study. J Indian Soc Periodontol. 2023 Nov-Dec;27(6):619-625. doi: 10.4103/jisp.jisp_43_23. Epub 2024 Jan 24.
- Amer O, Shemais N, Fawzy El-Sayed K, Saleh HA, Darhous M. Does Injectable Platelet-Rich Fibrin Combined With Autogenous Demineralized Dentine Enhance Alveolar Ridge Preservation? A Randomized Controlled Trial. Clin Oral Implants Res. 2025 Feb;36(2):166-177. doi: 10.1111/clr.14372. Epub 2024 Oct 21.
- Elbehwashy MT, Hosny MM, Elfana A, Saleh HA, Fawzy El-Sayed K. Autogenous Demineralized Dentin Graft-Based Strategies With or Without I-PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial. J Periodontal Res. 2026 Feb 20. doi: 10.1111/jre.70092. Online ahead of print.
- Braga YF, Maferano EF, Lopes TS, Neto MR, Macas LE, Costa FW. Autogenous dentin grafts in implant dentistry: A scoping review of clinical applications and processing protocols. Med Oral Patol Oral Cir Bucal. 2026 Mar 1;31(2):e251-e258. doi: 10.4317/medoral.27733.
- Xu Y, Zhang H. Clinical, radiographic, and histological evaluation of autogenous demineralized dentin matrix versus xenograft in alveolar ridge preservation: a randomized controlled trial. Int J Implant Dent. 2026 May 22;12(1):26. doi: 10.1186/s40729-026-00682-6.
- Luu VQ, Le ND, Nguyen BT, Le SH. In vitro characterization of tooth-derived and dentin-derived graft particles: Comparative analysis of particle size, mineral composition, and cytotoxicity. J Dent Sci. 2026 Jul 1;21(3):1723-1731. doi: 10.1016/j.jds.2025.07.3540. eCollection 2026.
- Mohammed IA, Elbackly RM, Badr AE-S. Relation between dentin scaffold/EDTA exposure time duration and the endogenous bone morphogenic protein 7 release. Egypt Dent J. 2023. doi:10.21608/edj.2023.225162.2655.
- Jaworski A, Zawiślak I, Pajączkowska M, Nowicka J, Kosior P, Watras A, et al. Microbiological purity of autogenous dental augmentative material after processing with an alkaline ethanol solution-in vitro study. Appl Sci. 2026;16(1):238. doi:10.3390/app16010238.
- Calvo-Guirado JL, Garcés-Villalá MA, Mahesh L, De Carlos-Villafranca FA. Effectiveness of chemical disinfection in discarding pathogenic bacteria of human particulate tooth graft: An in vitro study. Indian J Dent Sci. 2021;13(4):277-282. doi:10.4103/IJDS.IJDS_79_21.
- Calvo-Guirado JL, Cabo-Pastor MB, Martinez-Martinez F, Garces-Villala MA, de Carlos-Villafranca F, Garcia-Carrillo N, Fernandez-Dominguez M. The Use of Human Sterilized Crushed Tooth Particles Compared with BTCP Biomaterial and Empty Defects in Bone Formation inside Critical Rabbit Calvaria Sites. Bioengineering (Basel). 2023 May 24;10(6):638. doi: 10.3390/bioengineering10060638.
- Park M, Mah YJ, Kim DH, Kim ES, Park EJ. Demineralized deciduous tooth as a source of bone graft material: its biological and physicochemical characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Sep;120(3):307-14. doi: 10.1016/j.oooo.2015.05.021. Epub 2015 Jun 15.
- Schmidt-Schultz TH, Schultz M. Intact growth factors are conserved in the extracellular matrix of ancient human bone and teeth: a storehouse for the study of human evolution in health and disease. Biol Chem. 2005 Aug;386(8):767-76. doi: 10.1515/BC.2005.090.
- Sanchez-Labrador L, Bazal-Bonelli S, Perez-Gonzalez F, Saez-Alcaide LM, Cortes-Breton Brinkmann J, Martinez-Gonzalez JM. Autogenous particulated dentin for alveolar ridge preservation. A systematic review. Ann Anat. 2023 Feb;246:152024. doi: 10.1016/j.aanat.2022.152024. Epub 2022 Nov 14.
- Mardas N, Macbeth N, Donos N, Jung RE, Zuercher AN. Is alveolar ridge preservation an overtreatment? Periodontol 2000. 2023 Oct;93(1):289-308. doi: 10.1111/prd.12508. Epub 2023 Aug 25.
- Stumbras A, Kuliesius P, Januzis G, Juodzbalys G. Alveolar Ridge Preservation after Tooth Extraction Using Different Bone Graft Materials and Autologous Platelet Concentrates: a Systematic Review. J Oral Maxillofac Res. 2019 Mar 31;10(1):e2. doi: 10.5037/jomr.2019.10102. eCollection 2019 Jan-Mar.
- Avila-Ortiz G, Couso-Queiruga E, Stuhr S, Chambrone L. Long-term outcomes of post-extraction alveolar ridge preservation and alveolar ridge reconstruction followed by delayed implant placement: A systematic review. Periodontol 2000. 2025 Jul 3. doi: 10.1111/prd.12642. Online ahead of print.
- Allen HT, Zellner JW, Kotsakis GA, Mealey BL. Long-term preservation of ridge dimension following tooth extraction and ridge preservation: A randomized controlled trial of healing at 4- and 12-month healing time points. J Periodontol. 2022 Aug;93(8):1183-1190. doi: 10.1002/JPER.21-0607. Epub 2022 Feb 21.
Tanulmányi rekorddátumok
Ezek a dátumok nyomon követik a ClinicalTrials.gov webhelyre benyújtott vizsgálati rekordok és összefoglaló eredmények benyújtásának folyamatát. A vizsgálati feljegyzéseket és a jelentett eredményeket a Nemzeti Orvostudományi Könyvtár (NLM) felülvizsgálja, hogy megbizonyosodjon arról, hogy megfelelnek-e az adott minőség-ellenőrzési szabványoknak, mielőtt közzéteszik őket a nyilvános weboldalon.
Tanulmány főbb dátumok
Tanulmány kezdete (Becsült)
2026. október 30.
Elsődleges befejezés (Becsült)
2027. március 30.
A tanulmány befejezése (Becsült)
2027. június 30.
Tanulmányi regisztráció dátumai
Először benyújtva
2026. október 17.
Először nyújtották be, amely megfelel a minőségbiztosítási kritériumoknak
2026. október 31.
Első közzététel (Tényleges)
2026. november 4.
Tanulmányi rekordok frissítései
Utolsó frissítés közzétéve (Tényleges)
2026. november 4.
Az utolsó frissítés elküldve, amely megfelel a minőségbiztosítási kritériumoknak
2026. október 31.
Utolsó ellenőrzés
2026. október 1.
Több információ
A tanulmányhoz kapcsolódó kifejezések
Kulcsszavak
További vonatkozó MeSH feltételek
Egyéb vizsgálati azonosító számok
- 00D-9-26-8
Terv az egyéni résztvevői adatokhoz (IPD)
Tervezi megosztani az egyéni résztvevői adatokat (IPD)?
NEM
IPD terv leírása
Individual participant data will not be shared with other researchers. Only aggregated study results may be disseminated through scientific publications, while participant confidentiality and data privacy will be maintained in accordance with institutional ethical requirements.
Gyógyszer- és eszközinformációk, tanulmányi dokumentumok
Egy amerikai FDA által szabályozott gyógyszerkészítményt tanulmányoz
Nem
Egy amerikai FDA által szabályozott eszközterméket tanulmányoz
Nem
Ezt az információt közvetlenül a clinicaltrials.gov webhelyről szereztük be, változtatás nélkül. Ha bármilyen kérése van vizsgálati adatainak módosítására, eltávolítására vagy frissítésére, kérjük, írjon a következő címre: register@clinicaltrials.gov. Amint a változás bevezetésre kerül a clinicaltrials.gov oldalon, ez a webhelyünkön is automatikusan frissül. .