Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study (ARTEMIS)
30 settembre 2019 aggiornato da: AstraZeneca
Current patterns of P2Y12 receptor inhibitor use provide an excellent opportunity to test the impact of copayment reduction on clinician choice of medication, patient adherence, and clinical outcomes.
The ARTEMIS trial is a practical multicenter, cluster- randomized clinical trial that will assess the impact of copayment reduction by equalizing the copayment of clopidogrel and ticagrelor.
ARTEMIS will assess prescribing patterns, patient medication adherence, and clinical outcomes up to one year.
We hypothesize that reducing out--of--pocket cost for P2Y12 receptor inhibitor will lead to improved adherence.
Additionally, copayment reduction of both generic and brand antiplatelet agents may lead to a reduction in MACE risk.
This is in part due to greater adherence to an evidence--based secondary prevention medication.
Additionally the reduction in MACE may reflect greater selection of a more potent antiplatelet agent that has been shown to reduce MACE in randomized clinical trials, as provider choice of antiplatelet therapy will be primarily driven by risk- benefit assessment rather than the cost burden to the patient.
Panoramica dello studio
Stato
Completato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
ARTEMIS is a prospective, cluster-randomized clinical trial that will evaluate whether patient copayment elimination significantly influences antiplatelet therapy selection and long-term adherence, as well as patient outcomes and overall cost of care after acute myocardial infarction.
Approximately 11,000 patients with ST-elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) will be enrolled at the approximately 300 hospitals in this study.
Study sites selected for ARTEMIS will be geographically diverse, and will represent a diversity of hospital types and capabilities (e.g., teaching hospital, community hospital, etc).
After institutional review board (IRB) approval of the study, each hospital will be randomized into either the intervention arm or the control arm.
Hospitals randomized to the intervention arm will have the opportunity to offer enrolled patients either clopidogrel (generic P2Y12 receptor inhibitor option) or ticagrelor (brand P2Y12 receptor inhibitor option) without patient contribution to copayment in the next 12 months after the index MI discharge.
Hospitals in the control arm will provide care per usual clinical routine.
Notably, for both intervention and control arms, all patient management decisions (including the choice of antiplatelet therapy) are completely at the discretion of the care providers.
Duration of antiplatelet therapy will also be at the discretion of care providers.
All enrolled patients will be followed up to 15 months after index MI discharge to collect data on longitudinal treatment patterns and outcomes.
Primary and secondary endpoints will be assessed at 12 months.
An additional three months of follow up will assess for antiplatelet persistence and clinical events after discontinuation of the copayment intervention.
Centralized follow-up will be conducted every 3 months via telephone or web-based contact.
Tipo di studio
Interventistico
Iscrizione (Effettivo)
11001
Fase
- Fase 4
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Caguas, Porto Rico, 00725
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Alabama
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Birmingham, Alabama, Stati Uniti, 35294
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Huntsville, Alabama, Stati Uniti, 35613
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Mobile, Alabama, Stati Uniti, 36608
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Mobile, Alabama, Stati Uniti, 36617
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Alaska
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Anchorage, Alaska, Stati Uniti, 99508
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Arizona
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Cottonwood, Arizona, Stati Uniti, 86326
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Flagstaff, Arizona, Stati Uniti, 86001
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Phoenix, Arizona, Stati Uniti, 85008
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Arkansas
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Fayetteville, Arkansas, Stati Uniti, 72703
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Fort Smith, Arkansas, Stati Uniti, 72901
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Jonesboro, Arkansas, Stati Uniti, 72401
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Little Rock, Arkansas, Stati Uniti, 72211
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California
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Escondido, California, Stati Uniti, 92025
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Huntington Beach, California, Stati Uniti, 92648
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Loma Linda, California, Stati Uniti, 92354
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Los Angeles, California, Stati Uniti, 90048
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Los Angeles, California, Stati Uniti, 90095
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Northridge, California, Stati Uniti, 91328
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Pasadena, California, Stati Uniti, 91105
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Riverside, California, Stati Uniti, 92501
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Salinas, California, Stati Uniti, 93901
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Stockton, California, Stati Uniti, 95210
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Thousand Oaks, California, Stati Uniti, 91360
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Torrance, California, Stati Uniti, 90505-5073
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Vista, California, Stati Uniti, 92083
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Colorado
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Aurora, Colorado, Stati Uniti, 80045
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Aurora, Colorado, Stati Uniti, 80012
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Colorado Springs, Colorado, Stati Uniti, 80907
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Denver, Colorado, Stati Uniti, 80204
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Connecticut
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Bridgeport, Connecticut, Stati Uniti, 06610
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Danbury, Connecticut, Stati Uniti, 6810
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New Haven, Connecticut, Stati Uniti, 06519
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Stamford, Connecticut, Stati Uniti, 06904
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Florida
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Boynton Beach, Florida, Stati Uniti, 33435
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Bradenton, Florida, Stati Uniti, 34205
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Bradenton, Florida, Stati Uniti, 34209
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Daytona Beach, Florida, Stati Uniti, 32114
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Gainesville, Florida, Stati Uniti, 32607
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Hollywood, Florida, Stati Uniti, 33021
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Hudson, Florida, Stati Uniti, 34667
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Jacksonville, Florida, Stati Uniti, 32207
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Jacksonville, Florida, Stati Uniti, 32204
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Jacksonville, Florida, Stati Uniti, 32216
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Jacksonville, Florida, Stati Uniti, 32258
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Jacksonville Beach, Florida, Stati Uniti, 32250
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Lakeland, Florida, Stati Uniti, 33805
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Largo, Florida, Stati Uniti, 33770
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Miami, Florida, Stati Uniti, 33133
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Ocala, Florida, Stati Uniti, 34474
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Orlando, Florida, Stati Uniti, 32803
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Panama City, Florida, Stati Uniti, 32401
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Pensacola, Florida, Stati Uniti, 32501
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Pensacola, Florida, Stati Uniti, 32504
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Safety Harbor, Florida, Stati Uniti, 34695
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Saint Petersburg, Florida, Stati Uniti, 33713
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Saint Petersburg, Florida, Stati Uniti, 33709
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Saint Petersburg, Florida, Stati Uniti, 33701
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Sarasota, Florida, Stati Uniti, 34239
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Tallahassee, Florida, Stati Uniti, 32308
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Tampa, Florida, Stati Uniti, 33607
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Tampa, Florida, Stati Uniti, 33613
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Winter Haven, Florida, Stati Uniti, 33881
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Georgia
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Athens, Georgia, Stati Uniti, 30606
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Atlanta, Georgia, Stati Uniti, 30342
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Atlanta, Georgia, Stati Uniti, 30303
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Augusta, Georgia, Stati Uniti, 30912
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Cumming, Georgia, Stati Uniti, 30041
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Lawrenceville, Georgia, Stati Uniti, 30045
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Macon, Georgia, Stati Uniti, 31217
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Macon, Georgia, Stati Uniti, 31210
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Marietta, Georgia, Stati Uniti, 30060
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Suwanee, Georgia, Stati Uniti, 30024
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Hawaii
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Honolulu, Hawaii, Stati Uniti, 96813
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Idaho
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Coeur d'Alene, Idaho, Stati Uniti, 83814
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Illinois
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Aurora, Illinois, Stati Uniti, 60504
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Belleville, Illinois, Stati Uniti, 62226
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Chicago, Illinois, Stati Uniti, 60612
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Chicago, Illinois, Stati Uniti, 60637
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Joliet, Illinois, Stati Uniti, 60435
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Peoria, Illinois, Stati Uniti, 61614
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Rockford, Illinois, Stati Uniti, 61107
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Rockford, Illinois, Stati Uniti, 61103
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Springfield, Illinois, Stati Uniti, 62701
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Urbana, Illinois, Stati Uniti, 51801
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Indiana
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Bloomington, Indiana, Stati Uniti, 47403
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Englewood, Indiana, Stati Uniti, 7631
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Indianapolis, Indiana, Stati Uniti, 46237
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Indianapolis, Indiana, Stati Uniti, 46250
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Indianapolis, Indiana, Stati Uniti, 46290
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Muncie, Indiana, Stati Uniti, 47303
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Munster, Indiana, Stati Uniti, 46321
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Richmond, Indiana, Stati Uniti, 47375
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South Bend, Indiana, Stati Uniti, 46601
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Valparaiso, Indiana, Stati Uniti, 46383
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Iowa
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Davenport, Iowa, Stati Uniti, 52803
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Iowa City, Iowa, Stati Uniti, 52242
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West Des Moines, Iowa, Stati Uniti, 50266
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Kansas
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Overland Park, Kansas, Stati Uniti, 66209
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Kentucky
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Lexington, Kentucky, Stati Uniti, 40503
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Louisville, Kentucky, Stati Uniti, 40202
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Louisville, Kentucky, Stati Uniti, 40205
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Louisville, Kentucky, Stati Uniti, 40292
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Louisiana
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Alexandria, Louisiana, Stati Uniti, 71301
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Bossier City, Louisiana, Stati Uniti, 71111
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New Orleans, Louisiana, Stati Uniti, 70121
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Shreveport, Louisiana, Stati Uniti, 71103
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Maine
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Rockport, Maine, Stati Uniti, 04856
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Maryland
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Annapolis, Maryland, Stati Uniti, 21401
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Baltimore, Maryland, Stati Uniti, 21229
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Baltimore, Maryland, Stati Uniti, 21215
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Bethesda, Maryland, Stati Uniti, 20814
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Clinton, Maryland, Stati Uniti, 20735
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Columbia, Maryland, Stati Uniti, 21044
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Rockville, Maryland, Stati Uniti, 20850
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Salisbury, Maryland, Stati Uniti, 21804
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Massachusetts
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Boston, Massachusetts, Stati Uniti, 2215
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Boston, Massachusetts, Stati Uniti, 02118
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Brighton, Massachusetts, Stati Uniti, 2135
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Hyannis, Massachusetts, Stati Uniti, 02601
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Worcester, Massachusetts, Stati Uniti, 1655
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Michigan
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Alpena, Michigan, Stati Uniti, 49707
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Ann Arbor, Michigan, Stati Uniti, 48109
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Bay City, Michigan, Stati Uniti, 48708
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Detroit, Michigan, Stati Uniti, 48202
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Detroit, Michigan, Stati Uniti, 48236
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Flint, Michigan, Stati Uniti, 48532
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Grand Blanc, Michigan, Stati Uniti, 48439
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Grand Rapids, Michigan, Stati Uniti, 49503
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Jackson, Michigan, Stati Uniti, 39216
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Marquette, Michigan, Stati Uniti, 49855
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Mount Clemens, Michigan, Stati Uniti, 48043
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Petoskey, Michigan, Stati Uniti, 49770
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Pontiac, Michigan, Stati Uniti, 48341
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Saginaw, Michigan, Stati Uniti, 48602
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Saint Joseph, Michigan, Stati Uniti, 49085
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Southfield, Michigan, Stati Uniti, 48075
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Warren, Michigan, Stati Uniti, 48093
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Minnesota
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Duluth, Minnesota, Stati Uniti, 55805
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Minneapolis, Minnesota, Stati Uniti, 55407
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Saint Cloud, Minnesota, Stati Uniti, 56303
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Saint Paul, Minnesota, Stati Uniti, 55101
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Saint Paul, Minnesota, Stati Uniti, 55102
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Mississippi
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Hattiesburg, Mississippi, Stati Uniti, 39401
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Missouri
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Bridgeton, Missouri, Stati Uniti, 63044
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Fenton, Missouri, Stati Uniti, 63026
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Joplin, Missouri, Stati Uniti, 64804
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Kansas City, Missouri, Stati Uniti, 64114
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Kansas City, Missouri, Stati Uniti, 64111
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North Kansas City, Missouri, Stati Uniti, 64116
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Saint Charles, Missouri, Stati Uniti, 63301
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Saint Louis, Missouri, Stati Uniti, 63110
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Saint Louis, Missouri, Stati Uniti, 63136
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Saint Louis, Missouri, Stati Uniti, 63117
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Saint Louis, Missouri, Stati Uniti, 63128
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Saint Louis, Missouri, Stati Uniti, 63131-2374
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Saint Louis, Missouri, Stati Uniti, 63367
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Montana
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Billings, Montana, Stati Uniti, 59101
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Nebraska
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Lincoln, Nebraska, Stati Uniti, 68506
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Lincoln, Nebraska, Stati Uniti, 68526
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Omaha, Nebraska, Stati Uniti, 68131
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Omaha, Nebraska, Stati Uniti, 68105
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Omaha, Nebraska, Stati Uniti, 68154
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Nevada
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Las Vegas, Nevada, Stati Uniti, 89128
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Reno, Nevada, Stati Uniti, 89502
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Reno, Nevada, Stati Uniti, 89503
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New Jersey
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Bridgewater, New Jersey, Stati Uniti, 08807
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Flemington, New Jersey, Stati Uniti, 08822
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Haddon Heights, New Jersey, Stati Uniti, 08035
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Haddon Heights, New Jersey, Stati Uniti, 8035
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Moorestown, New Jersey, Stati Uniti, 08057
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Newark, New Jersey, Stati Uniti, 07102
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Paterson, New Jersey, Stati Uniti, 07503
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Pomona, New Jersey, Stati Uniti, 08240
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Ridgewood, New Jersey, Stati Uniti, 07450
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Teaneck, New Jersey, Stati Uniti, 07666
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Voorhees, New Jersey, Stati Uniti, 08043
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New York
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Albany, New York, Stati Uniti, 12205
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Cooperstown, New York, Stati Uniti, 13326
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Johnson City, New York, Stati Uniti, 13790
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New York, New York, Stati Uniti, 10029
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Poughkeepsie, New York, Stati Uniti, 12601
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Rochester, New York, Stati Uniti, 14621-3001
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Schenectady, New York, Stati Uniti, 12308
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Staten Island, New York, Stati Uniti, 10310
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Stony Brook, New York, Stati Uniti, 11794
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Utica, New York, Stati Uniti, 13501
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Valhalla, New York, Stati Uniti, 10595
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North Carolina
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Asheville, North Carolina, Stati Uniti, 28803
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Durham, North Carolina, Stati Uniti, 27710
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Gastonia, North Carolina, Stati Uniti, 28054
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High Point, North Carolina, Stati Uniti, 27262
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Lumberton, North Carolina, Stati Uniti, 28358
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Morehead City, North Carolina, Stati Uniti, 28557
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Pinehurst, North Carolina, Stati Uniti, 28374
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Raleigh, North Carolina, Stati Uniti, 27607
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Raleigh, North Carolina, Stati Uniti, 27610
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Wilmington, North Carolina, Stati Uniti, 28403
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Winston-Salem, North Carolina, Stati Uniti, 27104
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North Dakota
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Grand Forks, North Dakota, Stati Uniti, 58201
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Ohio
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Canton, Ohio, Stati Uniti, 447018
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Cincinnati, Ohio, Stati Uniti, 45267
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Cleveland, Ohio, Stati Uniti, 44106
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Dayton, Ohio, Stati Uniti, 45406
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Kettering, Ohio, Stati Uniti, 45429
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Middleburg Heights, Ohio, Stati Uniti, 44130
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Toledo, Ohio, Stati Uniti, 43615
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Oklahoma
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Oklahoma City, Oklahoma, Stati Uniti, 73112
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Oklahoma City, Oklahoma, Stati Uniti, 73120
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Oregon
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Bend, Oregon, Stati Uniti, 97701
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Portland, Oregon, Stati Uniti, 97062
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Tualatin, Oregon, Stati Uniti, 97062
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Pennsylvania
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Abington, Pennsylvania, Stati Uniti, 19001
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Allentown, Pennsylvania, Stati Uniti, 18103
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Camp Hill, Pennsylvania, Stati Uniti, 17011
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Chambersburg, Pennsylvania, Stati Uniti, 17201
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Danville, Pennsylvania, Stati Uniti, 17822
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Doylestown, Pennsylvania, Stati Uniti, 18901
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Lancaster, Pennsylvania, Stati Uniti, 17603
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Philadelphia, Pennsylvania, Stati Uniti, 19102
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Pittsburgh, Pennsylvania, Stati Uniti, 15212
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Pittsburgh, Pennsylvania, Stati Uniti, 15232
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Sayre, Pennsylvania, Stati Uniti, 18840
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Scranton, Pennsylvania, Stati Uniti, 18508
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Sellersville, Pennsylvania, Stati Uniti, 18960
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West Reading, Pennsylvania, Stati Uniti, 19611
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Wilkes-Barre, Pennsylvania, Stati Uniti, 18711
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York, Pennsylvania, Stati Uniti, 17403
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York, Pennsylvania, Stati Uniti, 17405
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Rhode Island
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Warwick, Rhode Island, Stati Uniti, 02886
- Research Site
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South Carolina
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Anderson, South Carolina, Stati Uniti, 29621
- Research Site
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Charleston, South Carolina, Stati Uniti, 29425
- Research Site
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Charleston, South Carolina, Stati Uniti, 29401
- Research Site
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Columbia, South Carolina, Stati Uniti, 29204
- Research Site
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Columbia, South Carolina, Stati Uniti, 29203
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Greenwood, South Carolina, Stati Uniti, 29646
- Research Site
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West Columbia, South Carolina, Stati Uniti, 29169
- Research Site
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South Dakota
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Rapid City, South Dakota, Stati Uniti, 57701
- Research Site
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Tennessee
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Jackson, Tennessee, Stati Uniti, 38301
- Research Site
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Knoxville, Tennessee, Stati Uniti, 37934
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Memphis, Tennessee, Stati Uniti, 38120
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Memphis, Tennessee, Stati Uniti, 38104
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Oak Ridge, Tennessee, Stati Uniti, 37830
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Texas
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Dallas, Texas, Stati Uniti, 75231
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Houston, Texas, Stati Uniti, 77030
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Houston, Texas, Stati Uniti, 77074
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New Braunfels, Texas, Stati Uniti, 78130
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Palestine, Texas, Stati Uniti, 75801
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Plano, Texas, Stati Uniti, 75093
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Round Rock, Texas, Stati Uniti, 78665
- Research Site
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San Antonio, Texas, Stati Uniti, 78201
- Research Site
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Temple, Texas, Stati Uniti, 76508
- Research Site
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Waco, Texas, Stati Uniti, 76712
- Research Site
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Webster, Texas, Stati Uniti, 77598
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Vermont
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Burlington, Vermont, Stati Uniti, 05401
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Virginia
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Charlottesville, Virginia, Stati Uniti, 22908
- Research Site
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Lynchburg, Virginia, Stati Uniti, 24501
- Research Site
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Norfolk, Virginia, Stati Uniti, 23507
- Research Site
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Richmond, Virginia, Stati Uniti, 23229
- Research Site
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Roanoke, Virginia, Stati Uniti, 24014
- Research Site
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Winchester, Virginia, Stati Uniti, 22601
- Research Site
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Washington
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Puyallup, Washington, Stati Uniti, 98372
- Research Site
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Renton, Washington, Stati Uniti, 98055
- Research Site
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Spokane, Washington, Stati Uniti, 99204
- Research Site
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West Virginia
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Morgantown, West Virginia, Stati Uniti, 26505
- Research Site
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Wisconsin
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Green Bay, Wisconsin, Stati Uniti, 54301
- Research Site
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La Crosse, Wisconsin, Stati Uniti, 54601
- Research Site
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Milwaukee, Wisconsin, Stati Uniti, 53226
- Research Site
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Milwaukee, Wisconsin, Stati Uniti, 53215
- Research Site
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Milwaukee, Wisconsin, Stati Uniti, 53211
- Research Site
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Racine, Wisconsin, Stati Uniti, 53405
- Research Site
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Waukesha, Wisconsin, Stati Uniti, 53188
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
Da 18 anni a 130 anni (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
Patients are eligible to be included in the study if they meet all of the following criteria:
- are ≥ 18 years of age
- have been diagnosed with STEMI or NSTEMI during the index hospitalization
- be treated with a P2Y12 receptor inhibitor at the time of enrollment
- have U.S. based health insurance coverage with prescription drug benefit
- have been fully informed and are able to provide written consent for longitudinal follow-up
Exclusion Criteria:
Patients are excluded if they meet any of the following criteria:
- have a history of prior intracranial hemorrhage
- have any contraindications to P2Y12 receptor inhibitor therapy at discharge
- involvement in another research study that specifies the type and duration of P2Y12 receptor inhibitor use within the next 12 months.
- have a life expectancy of less than one year
- have plans to move outside the US in the next year
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Ricerca sui servizi sanitari
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Copayment Intervention Arm
Sites in the intervention arm will provide patients with a study voucher card to offset any patient copayments or medication card for the filling of any prescriptions of clopidogrel or ticagrelor.
|
Study voucher card to offset any patient copayments or medication costs for the filling of any prescriptions of clopidogrel or ticagrelor
|
|
Nessun intervento: Usual Care Arm
For hospitals randomized to the control arm, all patients receive usual care and no study intervention is performed.
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Kaplan-Meier Cumulative Incidence Rate of Major Adverse Cardiovascular Events
Lasso di tempo: 12 months
|
To determine if patient copayment reduction leads to lower risk of MACE (composite of death, MI, and stroke) at 1 year after discharge.
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12 months
|
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Percentage of Patients With Long Term Non-persistence to P2Y12 Receptor Inhibitor
Lasso di tempo: 12 months
|
To determine if patient copayment reduction leads to higher long-term persistence of any P2Y12 receptor inhibitor at 1 year after discharge.
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12 months
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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P2Y12 Receptor Inhibitor Selection
Lasso di tempo: 12 months
|
To evaluate whether reducing patient copayments for both generic and brand P2Y12 receptor inhibitor options affects medication selection at discharge.
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12 months
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Collaboratori
Investigatori
- Investigatore principale: Tracy Wang, MD, MHS, MSc, Duke University
- Cattedra di studio: Eric Peterson, MD, MPH, FAHA, FACC, Duke University
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Rymer JA, Kaltenbach LA, Peterson ED, Cohen DJ, Fonarow GC, Choudhry NK, Henry TD, Cannon CP, Wang TY. Does the Effectiveness of a Medicine Copay Voucher Vary by Baseline Medication Out-Of-Pocket Expenses? Insights From ARTEMIS. J Am Heart Assoc. 2022 Oct 18;11(20):e026421. doi: 10.1161/JAHA.122.026421. Epub 2022 Oct 17.
- Fanaroff AC, Peterson ED, Kaltenbach LA, Anstrom KJ, Fonarow GC, Henry TD, Cannon CP, Choudhry NK, Cohen DJ, Atreja N, Bhalla N, Eudicone JM, Wang TY. Copayment Reduction Voucher Utilization and Associations With Medication Persistence and Clinical Outcomes: Findings From the ARTEMIS Trial. Circ Cardiovasc Qual Outcomes. 2020 May;13(5):e006182. doi: 10.1161/CIRCOUTCOMES.119.006182. Epub 2020 May 12.
- Doll JA, Kaltenbach LA, Anstrom KJ, Cannon CP, Henry TD, Fonarow GC, Choudhry NK, Fonseca E, Bhalla N, Eudicone JM, Peterson ED, Wang TY. Impact of a Copayment Reduction Intervention on Medication Persistence and Cardiovascular Events in Hospitals With and Without Prior Medication Financial Assistance Programs. J Am Heart Assoc. 2020 Apr 21;9(8):e014975. doi: 10.1161/JAHA.119.014975. Epub 2020 Apr 17.
- Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY. Agreement and Accuracy of Medication Persistence Identified by Patient Self-report vs Pharmacy Fill: A Secondary Analysis of the Cluster Randomized ARTEMIS Trial. JAMA Cardiol. 2020 May 1;5(5):532-539. doi: 10.1001/jamacardio.2020.0125.
- Fanaroff AC, Peterson ED, Kaltenbach LA, Cannon CP, Choudhry NK, Henry TD, Anstrom KJ, Cohen DJ, Fonseca E, Khan ND, Fonarow GC, Wang TY. Association of a P2Y12 Inhibitor Copayment Reduction Intervention With Persistence and Adherence With Other Secondary Prevention Medications: A Post Hoc Analysis of the ARTEMIS Cluster-Randomized Clinical Trial. JAMA Cardiol. 2020 Jan 1;5(1):38-46. doi: 10.1001/jamacardio.2019.4408.
- Wang TY, Kaltenbach LA, Cannon CP, Fonarow GC, Choudhry NK, Henry TD, Cohen DJ, Bhandary D, Khan ND, Anstrom KJ, Peterson ED. Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial Infarction: The ARTEMIS Randomized Clinical Trial. JAMA. 2019 Jan 1;321(1):44-55. doi: 10.1001/jama.2018.19791.
Collegamenti utili
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
5 giugno 2015
Completamento primario (Effettivo)
23 ottobre 2017
Completamento dello studio (Effettivo)
23 ottobre 2017
Date di iscrizione allo studio
Primo inviato
30 marzo 2015
Primo inviato che soddisfa i criteri di controllo qualità
1 aprile 2015
Primo Inserito (Stima)
2 aprile 2015
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
1 ottobre 2019
Ultimo aggiornamento inviato che soddisfa i criteri QC
30 settembre 2019
Ultimo verificato
1 settembre 2019
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- D5130R00030
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .