S9927 Radiation Therapy After Surgery, Chemotherapy, and/or Hormone Therapy in Stage II Breast Cancer
Randomized Trial of Post-Mastectomy Radiotherapy in Stage II Breast Cancer in Women With One to Three Positive Axillary Nodes Phase III
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether mastectomy, chemotherapy, and/or hormone therapy are more effective with or without radiation therapy in treating breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of mastectomy, chemotherapy, and/or hormone therapy with or without radiation therapy in treating women who have stage II breast cancer.
調査の概要
詳細な説明
OBJECTIVES:
- Compare overall and disease-free survival in women with stage II breast cancer with one to three positive nodes treated with radiotherapy vs observation only after mastectomy and adjuvant chemotherapy and/or hormonal therapy.
- Compare local regional control in patients treated with these regimens.
- Assess the potential toxic effects of radiotherapy in this patient population.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to prior systemic hormonal therapy (chemotherapy with or without hormonal therapy vs hormonal therapy alone), prior taxane exposure (yes vs no), and duration of chemotherapy (no chemotherapy vs less than 3 months vs 3-5 months vs 6 months or more). Patients are randomized to one of two treatment arms.
- Arm I: Patients undergo radiotherapy 5 days a week for 5 weeks.
- Arm II: Patients are observed for disease progression. Patients are followed every 6 months for 2 years and then annually for 15 years.
PROJECTED ACCRUAL: A total of 2,500 patients (1,250 per treatment arm) will be accrued for this study within 5 years.
研究の種類
入学 (実際)
段階
- フェーズ 3
連絡先と場所
研究場所
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Ontario
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Hamilton、Ontario、カナダ、L8V 5C2
- Cancer Care Ontario-Hamilton Regional Cancer Centre
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
DISEASE CHARACTERISTICS:
Histologically confirmed stage II adenocarcinoma of the breast (T1-2, N1, M0)
- Primary tumor no greater than 5 cm
- At least 1 but no more than 3 positive axillary lymph nodes
- Nodes cannot be positive solely by cytokeratin staining
- No apocrine, adenocystic, or squamous cell carcinomas or sarcomas of the breast
- No bilateral breast cancer
- No active local regional disease
Must have undergone a modified radical mastectomy with a level I and II with or without a level III axillary dissection (at least 10 nodes examined) within the past 8 months
- Surgical margins negative for invasive and noninvasive ductal carcinoma
- No gross extracapsular disease or residual disease in the axilla
- Microscopic extracapsular extension allowed
- No mastectomy after local failure following lumpectomy
- Must have received adjuvant chemotherapy and/or hormonal therapy after mastectomy
Hormone receptor status:
- Not specified
PATIENT CHARACTERISTICS:
Age:
- 21 and over
Sex:
- Female
Menopausal status:
- Pre- or post-menopausal
Performance status:
- Zubrod 0-1
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
- No serious medical or psychiatric illness that would preclude study compliance
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- No prior trastuzumab (Herceptin)
Chemotherapy:
- See Disease Characteristics
- No more than 6 weeks since prior adjuvant chemotherapy
- No other prior chemotherapy
- Concurrent adjuvant chemotherapy allowed
Endocrine therapy:
- See Disease Characteristics
- Concurrent adjuvant hormonal therapy allowed
Radiotherapy:
- No prior chest wall or nodal radiotherapy
Surgery:
- See Disease Characteristics
- Breast reconstruction allowed
Other:
- Concurrent registration on another adjuvant chemotherapy or hormonal therapy study is allowed
研究計画
協力者と研究者
スポンサー
協力者
捜査官
- スタディチェア：Timothy J. Whelan, MD、Margaret and Charles Juravinski Cancer Centre
- スタディチェア：Lori J. Pierce, MD、University of Michigan Rogel Cancer Center
- スタディチェア：Stephen B. Edge, MD、Roswell Park Cancer Institute
- スタディチェア：Eric A. Strom, MD, FACR、M.D. Anderson Cancer Center
- スタディチェア：Lawrence J. Solin, MD, FACR、Abramson Cancer Center of the University of Pennsylvania
- スタディチェア：Lawrence B. Marks, MD、Duke University
- スタディチェア：Melvin Deutsch, MD、UPMC Cancer Center at UPMC Presbyterian
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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