Tacrolimus and Mycophenolate Mofetil in Preventing Acute Graft-Versus-Host Disease in Patients With Advanced Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation

DISEASE CHARACTERISTICS:

• Diagnosis of 1 of the following hematologic malignancies:

  • Acute myeloid leukemia beyond first complete remission (CR1)
  • Acute lymphoblastic leukemia beyond CR1
  • Chronic myelogenous leukemia in second chronic phase, accelerated phase, or blastic phase
  • Non-Hodgkin's lymphoma beyond CR2
  • Hodgkin's lymphoma beyond CR2
  • Multiple myeloma (any stage)
  • Myelodysplastic syndromes beyond refractory anemia (including chronic myelomonocytic leukemia)
  • Any refractory hematologic malignancy
• Advanced disease

• Scheduled for transplantation of mobilized allogeneic peripheral blood stem cells

  • Genotypically HLA-identical stem cell donor available

PATIENT CHARACTERISTICS:

Age

• 65 and under

Performance status

• Not specified

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Bilirubin ≤ 1.5 times upper limit of normal (ULN)
• SGOT and SGPT ≤ 2.0 times ULN

Renal

• Creatinine clearance ≥ 60 mL/min

Pulmonary

• No acute pulmonary infection by chest x-ray
• No severe hypoxemia (partial O_2 < 70% of predicted) AND DLCO < 70% of predicted
• No mild hypoxemia (partial O_2 < 80% of predicted) AND DLCO < 60% of predicted

Other

• Not pregnant or nursing
• Negative pregnancy test
• No active systemic infection not controlled with antimicrobial therapy
• HIV negative (HIV-1 or other virus)

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No concurrent T-cell depleted hematopoietic stem cell graft

Chemotherapy

• Not specified

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified