Vitamin D, Steroids, and Asthma in African American Youth (AsthMaP2)
AsthMaP 2: Vitamin D, Steroids, and Asthma in African American Youth
Asthma has become considerably more prevalent and severe in the U.S. during the last 40 years, particularly affecting youth in urban areas, yet the reasons for this are not clear. There is increasing evidence that vitamin D insufficiency contributes to more severe asthma through increased risk of respiratory infections and decreased sensitivity to glucocorticoids. Indeed, low vitamin D levels are linked with the need for exogenous glucocorticoids and increased asthma severity. Particularly relevant to health disparities, we showed a strong association between vitamin D insufficiency and asthma in urban African American (AA) youth. Importantly, AA youth in ours and other studies had lower vitamin D levels than non-AA participants.
Because AA youth residing in urban Washington, DC have markedly worse asthma than other racial/ethnic groups (e.g. prevalence rate 20% higher than the national rate 15 and emergency department utilization rates up to 5 times the national rates and nearly 10 times the Healthy People 2010 target rate), we will utilize our access to this population at the extreme of asthma disparities to examine the contribution of vitamin D to disparities in the chronic control and acute severity of asthma. The overall goal of this study is to provide critical epidemiological/molecular information that will inform the interpretation of ongoing and impending randomized clinical trials of vitamin D supplementation in asthma, especially with regard to urban AA youth with asthma. We hypothesize that low serum 25-hydroxyvitamin D [25(OH)D] levels are associated with poor chronic asthma control, worse acute asthma severity, and glucocorticoid insensitivity. The knowledge generated by the experiments in this application will be crucial to translation of this inexpensive, easily-accessible, and thereby potentially disparity-reducing prospective therapy for asthma.
調査の概要
研究の種類
入学 (実際)
連絡先と場所
研究場所
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District of Columbia
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Washington、District of Columbia、アメリカ、20010
- Children's National Medical Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Between 6 and 20 years of age
- Physician-diagnosed asthma for 1 year or more
- Caretaker/Independent participant willing to sign the written Informed Consent, Assent form when appropriate
Exclusion Criteria:
- Significant, chronic medical illnesses other than asthma
- No access to a phone
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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Phenotypic Clusters
500 urban youth
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
時間枠 |
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Serum 25(OH)D measurement by liquid chromatography-tandem mass spectrometry
時間枠:one year
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one year
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協力者と研究者
スポンサー
捜査官
- 主任研究者:Robert J Freishtat, MD, MPH、Children's National Research Institute
出版物と役立つリンク
便利なリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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