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Decision-Making and the Relationship to Food Intake in Kids (DMK)

2021年1月7日 更新者:Kathleen Loralee Keller、Penn State University

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

調査の概要

状態

完了

条件

研究の種類

観察的

入学 (実際)

142

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究場所

    • Pennsylvania
      • University Park、Pennsylvania、アメリカ、16802
        • The Pennsylvania State University

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

7年~11年 (子)

健康ボランティアの受け入れ

はい

受講資格のある性別

全て

サンプリング方法

確率サンプル

調査対象母集団

Children aged 7-11 years old.

説明

Inclusion Criteria:

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

Exclusion Criteria:

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか?

デザインの詳細

この研究は何を測定していますか?

主要な結果の測定

結果測定
メジャーの説明
時間枠
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
時間枠:Collected at fMRI scan at week 4
Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types
Collected at fMRI scan at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)
時間枠:Collected at fMRI scan at week 4
Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest
Collected at fMRI scan at week 4
Behavioral inhibitory control task
時間枠:Collected at either week 1-3 (randomized)
Measured by performance on a go/nogo task
Collected at either week 1-3 (randomized)
Behavioral reward inhibitory control task
時間枠:Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Measured by performance on a go/nogo task with a reward incentive
Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Behavioral risk-taking and reward task
時間枠:Collected at either week 1-3 (randomized)
Measured by performance on the hungry donkey task
Collected at either week 1-3 (randomized)
Behavioral dietary self-control assessment
時間枠:Collected at either week 1-3 (randomized)
Measured by performance on a dietary self-control task
Collected at either week 1-3 (randomized)

二次結果の測定

結果測定
メジャーの説明
時間枠
Energy intake at baseline
時間枠:Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake at a buffet meal
時間枠:Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake after a meal preload
時間枠:Collected at either week 1-3 (randomized) following the baseline meal
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized) following the baseline meal
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
時間枠:Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline
時間枠:Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4

その他の成果指標

結果測定
メジャーの説明
時間枠
身長
時間枠:1週目に回収
スタディオメーターで測定した身長 (cm)
1週目に回収
体脂肪率
時間枠:1週目に回収
生体電気インピーダンス分析スケールによる評価
1週目に回収
食欲特性
時間枠:1週目に回収
子供の習慣的な食事スタイルに関する親からのアンケート
1週目に回収
Liking of foods
時間枠:Collected after each meal at multiple time points during weeks 1-4
Ratings of how much the child likes each food in the meal on a visual analog scale
Collected after each meal at multiple time points during weeks 1-4
Fullness feelings
時間枠:Collected at multiple time points during weeks 1-4
Ratings of how full the child feels measured on a child-friendly visual analog scale
Collected at multiple time points during weeks 1-4
Pubertal Development
時間枠:Collected at week 1
Child report of pubertal status questionnaire
Collected at week 1
Weight
時間枠:Collected at week 1
Weight in kg measured by a standard digital scale
Collected at week 1
Body mass index
時間枠:Collected at week 1
Calculated from height, age, sex
Collected at week 1
BMI percentile
時間枠:Collected at week 1
Calculated from height, weight, age and sex - according to the Center for Disease Control (CDC) standards
Collected at week 1
BMI z-score
時間枠:Collected at week 1
Calculated from height, weight, age and sex - according to CDC standards
Collected at week 1
Fat mass index
時間枠:Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Fat-free mass index
時間枠:Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Parental feeding strategies
時間枠:Collected at week 1
Parent-reported questionnaire of feeding practices
Collected at week 1
Family demographics
時間枠:Collected at week 1
Parent-report questionnaire
Collected at week 1
Loss of control eating
時間枠:Collected at week 4
Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.
Collected at week 4
Inhibitory control and reward sensitivity questionnaires
時間枠:Collected on either week 1-3 (randomized)
Parent and child report of inhibitory control and reward sensitivity on a questionnaire
Collected on either week 1-3 (randomized)
Age
時間枠:Collected at the week 1
Age of participant
Collected at the week 1
Sex
時間枠:collected at week 1
sex of participant
collected at week 1
Parent height
時間枠:collected at week 1
height in cm of parent measured by a stadiometer
collected at week 1
Parent weight
時間枠:collected at week 1
weight in kg of parent measured by a standard digital scale
collected at week 1
parent body fat
時間枠:collected at week 1
measured by bioelectrical impedance
collected at week 1
Puberty Assessment Parental Report
時間枠:Collected at week 1
Parent report of pubertal status questionnaire
Collected at week 1

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

捜査官

  • 主任研究者:Shana Adise, B.S.、The Pennsylvania State University

出版物と役立つリンク

研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (実際)

2015年4月1日

一次修了 (実際)

2016年10月1日

研究の完了 (実際)

2017年12月1日

試験登録日

最初に提出

2016年6月29日

QC基準を満たした最初の提出物

2016年8月3日

最初の投稿 (見積もり)

2016年8月4日

学習記録の更新

投稿された最後の更新 (実際)

2021年1月11日

QC基準を満たした最後の更新が送信されました

2021年1月7日

最終確認日

2021年1月1日

詳しくは

本研究に関する用語

その他の研究ID番号

  • DecisionMakingEatingKids01

個々の参加者データ (IPD) の計画

個々の参加者データ (IPD) を共有する予定はありますか?

いいえ

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