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Decision-Making and the Relationship to Food Intake in Kids (DMK)

2021年1月7日 更新者:Kathleen Loralee Keller、Penn State University

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

研究概览

地位

完全的

研究类型

观察性的

注册 (实际的)

142

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

    • Pennsylvania
      • University Park、Pennsylvania、美国、16802
        • The Pennsylvania State University

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

7年 至 11年 (孩子)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

概率样本

研究人群

Children aged 7-11 years old.

描述

Inclusion Criteria:

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

Exclusion Criteria:

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
大体时间:Collected at fMRI scan at week 4
Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types
Collected at fMRI scan at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)
大体时间:Collected at fMRI scan at week 4
Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest
Collected at fMRI scan at week 4
Behavioral inhibitory control task
大体时间:Collected at either week 1-3 (randomized)
Measured by performance on a go/nogo task
Collected at either week 1-3 (randomized)
Behavioral reward inhibitory control task
大体时间:Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Measured by performance on a go/nogo task with a reward incentive
Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Behavioral risk-taking and reward task
大体时间:Collected at either week 1-3 (randomized)
Measured by performance on the hungry donkey task
Collected at either week 1-3 (randomized)
Behavioral dietary self-control assessment
大体时间:Collected at either week 1-3 (randomized)
Measured by performance on a dietary self-control task
Collected at either week 1-3 (randomized)

次要结果测量

结果测量
措施说明
大体时间
Energy intake at baseline
大体时间:Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake at a buffet meal
大体时间:Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake after a meal preload
大体时间:Collected at either week 1-3 (randomized) following the baseline meal
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized) following the baseline meal
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
大体时间:Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline
大体时间:Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4

其他结果措施

结果测量
措施说明
大体时间
高度
大体时间:第 1 周收集
用测距仪测量的身高(厘米)
第 1 周收集
体脂率
大体时间:第 1 周收集
通过生物电阻抗分析量表评估
第 1 周收集
食欲特征
大体时间:第 1 周收集
儿童饮食习惯家长自报问卷
第 1 周收集
Liking of foods
大体时间:Collected after each meal at multiple time points during weeks 1-4
Ratings of how much the child likes each food in the meal on a visual analog scale
Collected after each meal at multiple time points during weeks 1-4
Fullness feelings
大体时间:Collected at multiple time points during weeks 1-4
Ratings of how full the child feels measured on a child-friendly visual analog scale
Collected at multiple time points during weeks 1-4
Pubertal Development
大体时间:Collected at week 1
Child report of pubertal status questionnaire
Collected at week 1
Weight
大体时间:Collected at week 1
Weight in kg measured by a standard digital scale
Collected at week 1
Body mass index
大体时间:Collected at week 1
Calculated from height, age, sex
Collected at week 1
BMI percentile
大体时间:Collected at week 1
Calculated from height, weight, age and sex - according to the Center for Disease Control (CDC) standards
Collected at week 1
BMI z-score
大体时间:Collected at week 1
Calculated from height, weight, age and sex - according to CDC standards
Collected at week 1
Fat mass index
大体时间:Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Fat-free mass index
大体时间:Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Parental feeding strategies
大体时间:Collected at week 1
Parent-reported questionnaire of feeding practices
Collected at week 1
Family demographics
大体时间:Collected at week 1
Parent-report questionnaire
Collected at week 1
Loss of control eating
大体时间:Collected at week 4
Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.
Collected at week 4
Inhibitory control and reward sensitivity questionnaires
大体时间:Collected on either week 1-3 (randomized)
Parent and child report of inhibitory control and reward sensitivity on a questionnaire
Collected on either week 1-3 (randomized)
Age
大体时间:Collected at the week 1
Age of participant
Collected at the week 1
Sex
大体时间:collected at week 1
sex of participant
collected at week 1
Parent height
大体时间:collected at week 1
height in cm of parent measured by a stadiometer
collected at week 1
Parent weight
大体时间:collected at week 1
weight in kg of parent measured by a standard digital scale
collected at week 1
parent body fat
大体时间:collected at week 1
measured by bioelectrical impedance
collected at week 1
Puberty Assessment Parental Report
大体时间:Collected at week 1
Parent report of pubertal status questionnaire
Collected at week 1

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

调查人员

  • 首席研究员:Shana Adise, B.S.、The Pennsylvania State University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2015年4月1日

初级完成 (实际的)

2016年10月1日

研究完成 (实际的)

2017年12月1日

研究注册日期

首次提交

2016年6月29日

首先提交符合 QC 标准的

2016年8月3日

首次发布 (估计)

2016年8月4日

研究记录更新

最后更新发布 (实际的)

2021年1月11日

上次提交的符合 QC 标准的更新

2021年1月7日

最后验证

2021年1月1日

更多信息

与本研究相关的术语

其他研究编号

  • DecisionMakingEatingKids01

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)?

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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