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Decision-Making and the Relationship to Food Intake in Kids (DMK)

7. januar 2021 oppdatert av: Kathleen Loralee Keller, Penn State University

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

Studieoversikt

Status

Fullført

Studietype

Observasjonsmessig

Registrering (Faktiske)

142

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

    • Pennsylvania
      • University Park, Pennsylvania, Forente stater, 16802
        • The Pennsylvania State University

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

7 år til 11 år (Barn)

Tar imot friske frivillige

Ja

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Sannsynlighetsprøve

Studiepopulasjon

Children aged 7-11 years old.

Beskrivelse

Inclusion Criteria:

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

Exclusion Criteria:

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
Tidsramme: Collected at fMRI scan at week 4
Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types
Collected at fMRI scan at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)
Tidsramme: Collected at fMRI scan at week 4
Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest
Collected at fMRI scan at week 4
Behavioral inhibitory control task
Tidsramme: Collected at either week 1-3 (randomized)
Measured by performance on a go/nogo task
Collected at either week 1-3 (randomized)
Behavioral reward inhibitory control task
Tidsramme: Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Measured by performance on a go/nogo task with a reward incentive
Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Behavioral risk-taking and reward task
Tidsramme: Collected at either week 1-3 (randomized)
Measured by performance on the hungry donkey task
Collected at either week 1-3 (randomized)
Behavioral dietary self-control assessment
Tidsramme: Collected at either week 1-3 (randomized)
Measured by performance on a dietary self-control task
Collected at either week 1-3 (randomized)

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Energy intake at baseline
Tidsramme: Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake at a buffet meal
Tidsramme: Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake after a meal preload
Tidsramme: Collected at either week 1-3 (randomized) following the baseline meal
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized) following the baseline meal
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
Tidsramme: Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline
Tidsramme: Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Høyde
Tidsramme: Hentes i uke 1
Høyde i cm målt med stadiometer
Hentes i uke 1
Kroppsfettprosent
Tidsramme: Hentes i uke 1
Vurdert ved bioelektrisk impedansanalyseskala
Hentes i uke 1
Appetitive egenskaper
Tidsramme: Hentes i uke 1
Foreldrerapportert spørreskjema om vanlige spisestiler hos barn
Hentes i uke 1
Liking of foods
Tidsramme: Collected after each meal at multiple time points during weeks 1-4
Ratings of how much the child likes each food in the meal on a visual analog scale
Collected after each meal at multiple time points during weeks 1-4
Fullness feelings
Tidsramme: Collected at multiple time points during weeks 1-4
Ratings of how full the child feels measured on a child-friendly visual analog scale
Collected at multiple time points during weeks 1-4
Pubertal Development
Tidsramme: Collected at week 1
Child report of pubertal status questionnaire
Collected at week 1
Weight
Tidsramme: Collected at week 1
Weight in kg measured by a standard digital scale
Collected at week 1
Body mass index
Tidsramme: Collected at week 1
Calculated from height, age, sex
Collected at week 1
BMI percentile
Tidsramme: Collected at week 1
Calculated from height, weight, age and sex - according to the Center for Disease Control (CDC) standards
Collected at week 1
BMI z-score
Tidsramme: Collected at week 1
Calculated from height, weight, age and sex - according to CDC standards
Collected at week 1
Fat mass index
Tidsramme: Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Fat-free mass index
Tidsramme: Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Parental feeding strategies
Tidsramme: Collected at week 1
Parent-reported questionnaire of feeding practices
Collected at week 1
Family demographics
Tidsramme: Collected at week 1
Parent-report questionnaire
Collected at week 1
Loss of control eating
Tidsramme: Collected at week 4
Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.
Collected at week 4
Inhibitory control and reward sensitivity questionnaires
Tidsramme: Collected on either week 1-3 (randomized)
Parent and child report of inhibitory control and reward sensitivity on a questionnaire
Collected on either week 1-3 (randomized)
Age
Tidsramme: Collected at the week 1
Age of participant
Collected at the week 1
Sex
Tidsramme: collected at week 1
sex of participant
collected at week 1
Parent height
Tidsramme: collected at week 1
height in cm of parent measured by a stadiometer
collected at week 1
Parent weight
Tidsramme: collected at week 1
weight in kg of parent measured by a standard digital scale
collected at week 1
parent body fat
Tidsramme: collected at week 1
measured by bioelectrical impedance
collected at week 1
Puberty Assessment Parental Report
Tidsramme: Collected at week 1
Parent report of pubertal status questionnaire
Collected at week 1

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Etterforskere

  • Hovedetterforsker: Shana Adise, B.S., The Pennsylvania State University

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. april 2015

Primær fullføring (Faktiske)

1. oktober 2016

Studiet fullført (Faktiske)

1. desember 2017

Datoer for studieregistrering

Først innsendt

29. juni 2016

Først innsendt som oppfylte QC-kriteriene

3. august 2016

Først lagt ut (Anslag)

4. august 2016

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

11. januar 2021

Siste oppdatering sendt inn som oppfylte QC-kriteriene

7. januar 2021

Sist bekreftet

1. januar 2021

Mer informasjon

Begreper knyttet til denne studien

Andre studie-ID-numre

  • DecisionMakingEatingKids01

Plan for individuelle deltakerdata (IPD)

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NEI

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