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Decision-Making and the Relationship to Food Intake in Kids (DMK)

7 janvier 2021 mis à jour par: Kathleen Loralee Keller, Penn State University

Understanding Decision-Making and the Relationship to Food Intake in Children 7 to 11 Years Old

The purpose of this 18-month project is to investigate how decision-making influences food choice and consumption in children ages 7 to 11 years old. Although several studies suggest that the ability to make good decisions relates to eating behaviors, no studies have looked at how food reward influences the decision-making process to impact actual food intake. This proposal will answer these questions and bridge this gap in knowledge, which could lead to the development of more effective interventions for childhood obesity. To accomplish this, the investigators have assembled a diverse team with expertise in food intake, nutrition, and decision sciences. First, the investigators will establish if there are differences in decision-making between children varying in weight status. Second, the investigators will determine if performance on behavioral decision-making tasks relates to food consumption in the laboratory. Third, the investigators will examine response functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response to various rewards (i.e. food and money) and determine if this is influenced by child weight status. Fourth, the investigators will examine differences in fMRI BOLD at rest in decision-making regions are correlated with food intake and weight status. Eighty-two children will participate in our study. The long-term goal of this project is to investigate if there are differences in brain regions corresponding to these behaviors in overweight children and if these differences relate to eating behaviors in this population. Children will undergo fMRI while playing a reward task as well as consume meals in our laboratory. Decision-making will also be assessed by having children complete various behavioral measurements of reward and inhibitory control.

Aperçu de l'étude

Statut

Complété

Les conditions

Type d'étude

Observationnel

Inscription (Réel)

142

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Lieux d'étude

    • Pennsylvania
      • University Park, Pennsylvania, États-Unis, 16802
        • The Pennsylvania State University

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

7 ans à 11 ans (Enfant)

Accepte les volontaires sains

Oui

Sexes éligibles pour l'étude

Tout

Méthode d'échantillonnage

Échantillon de probabilité

Population étudiée

Children aged 7-11 years old.

La description

Inclusion Criteria:

  • Right-handed
  • English as native language
  • Reading at/above grade level
  • Not Claustrophobic
  • Generally Healthy

Exclusion Criteria:

  • Left-handedness
  • Metal in or on body that cannot be removed
  • Claustrophobia
  • Medication usage that may alter brain activity or blood flow
  • Medical disorder that may impact comfort of safety in MRI scanner
  • Food Allergies
  • Dietary Restrictions
  • Learning Disabilities
  • Psychiatric Disorders

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
Délai: Collected at fMRI scan at week 4
Regions of interest BOLD analysis of an fMRI card-guessing task for various reward types
Collected at fMRI scan at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at rest (resting-state fMRI)
Délai: Collected at fMRI scan at week 4
Regions of interest BOLD analysis of resting-state fMRI to examine differences in brain regions of interest at rest
Collected at fMRI scan at week 4
Behavioral inhibitory control task
Délai: Collected at either week 1-3 (randomized)
Measured by performance on a go/nogo task
Collected at either week 1-3 (randomized)
Behavioral reward inhibitory control task
Délai: Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Measured by performance on a go/nogo task with a reward incentive
Collected after the behavioral inhibitory control task (same visit), which is either week 1-3 (randomized)
Behavioral risk-taking and reward task
Délai: Collected at either week 1-3 (randomized)
Measured by performance on the hungry donkey task
Collected at either week 1-3 (randomized)
Behavioral dietary self-control assessment
Délai: Collected at either week 1-3 (randomized)
Measured by performance on a dietary self-control task
Collected at either week 1-3 (randomized)

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
Energy intake at baseline
Délai: Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake at a buffet meal
Délai: Collected at either week 1-3 (randomized)
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized)
Energy intake after a meal preload
Délai: Collected at either week 1-3 (randomized) following the baseline meal
Measured at an objective laboratory test-meal (kcal and grams)
Collected at either week 1-3 (randomized) following the baseline meal
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response to various reward types (food, money, no reward).
Délai: Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4
Functional magnetic resonance imaging (fMRI), blood-oxygen-level-dependent (BOLD) response at baseline
Délai: Collected at week 4
Whole brain BOLD analysis of an fMRI card-guessing task for various reward types
Collected at week 4

Autres mesures de résultats

Mesure des résultats
Description de la mesure
Délai
Hauteur
Délai: Collecté à la semaine 1
Taille en cm mesurée au stadiomètre
Collecté à la semaine 1
Pourcentage de graisse corporelle
Délai: Collecté à la semaine 1
Évalué par une échelle d'analyse d'impédance bioélectrique
Collecté à la semaine 1
Traits d'appétit
Délai: Collecté à la semaine 1
Questionnaire déclaré par les parents sur les habitudes alimentaires des enfants
Collecté à la semaine 1
Liking of foods
Délai: Collected after each meal at multiple time points during weeks 1-4
Ratings of how much the child likes each food in the meal on a visual analog scale
Collected after each meal at multiple time points during weeks 1-4
Fullness feelings
Délai: Collected at multiple time points during weeks 1-4
Ratings of how full the child feels measured on a child-friendly visual analog scale
Collected at multiple time points during weeks 1-4
Pubertal Development
Délai: Collected at week 1
Child report of pubertal status questionnaire
Collected at week 1
Weight
Délai: Collected at week 1
Weight in kg measured by a standard digital scale
Collected at week 1
Body mass index
Délai: Collected at week 1
Calculated from height, age, sex
Collected at week 1
BMI percentile
Délai: Collected at week 1
Calculated from height, weight, age and sex - according to the Center for Disease Control (CDC) standards
Collected at week 1
BMI z-score
Délai: Collected at week 1
Calculated from height, weight, age and sex - according to CDC standards
Collected at week 1
Fat mass index
Délai: Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Fat-free mass index
Délai: Collected at week 1
Calculated from height, weight, age, sex
Collected at week 1
Parental feeding strategies
Délai: Collected at week 1
Parent-reported questionnaire of feeding practices
Collected at week 1
Family demographics
Délai: Collected at week 1
Parent-report questionnaire
Collected at week 1
Loss of control eating
Délai: Collected at week 4
Loss of control when eating is frequently reported in middle childhood. Loss of control when eating was assessed via interview-style questionnaire to determine pre-clinical binge-like eating behaviors that may influence the primary outcome of energy intake at the 4 conditions of test-meals.
Collected at week 4
Inhibitory control and reward sensitivity questionnaires
Délai: Collected on either week 1-3 (randomized)
Parent and child report of inhibitory control and reward sensitivity on a questionnaire
Collected on either week 1-3 (randomized)
Age
Délai: Collected at the week 1
Age of participant
Collected at the week 1
Sex
Délai: collected at week 1
sex of participant
collected at week 1
Parent height
Délai: collected at week 1
height in cm of parent measured by a stadiometer
collected at week 1
Parent weight
Délai: collected at week 1
weight in kg of parent measured by a standard digital scale
collected at week 1
parent body fat
Délai: collected at week 1
measured by bioelectrical impedance
collected at week 1
Puberty Assessment Parental Report
Délai: Collected at week 1
Parent report of pubertal status questionnaire
Collected at week 1

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Les enquêteurs

  • Chercheur principal: Shana Adise, B.S., The Pennsylvania State University

Publications et liens utiles

La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude (Réel)

1 avril 2015

Achèvement primaire (Réel)

1 octobre 2016

Achèvement de l'étude (Réel)

1 décembre 2017

Dates d'inscription aux études

Première soumission

29 juin 2016

Première soumission répondant aux critères de contrôle qualité

3 août 2016

Première publication (Estimation)

4 août 2016

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Réel)

11 janvier 2021

Dernière mise à jour soumise répondant aux critères de contrôle qualité

7 janvier 2021

Dernière vérification

1 janvier 2021

Plus d'information

Termes liés à cette étude

Autres numéros d'identification d'étude

  • DecisionMakingEatingKids01

Plan pour les données individuelles des participants (IPD)

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