Evaluation of Association Between Obstructive Sleep Apnea and the Severity of Coronary Artery Disease
The Prevalence and Influence of Obstructive Sleep Apnea in Coronary Artery Disease in Modern Age: Findings in A Large Cohort Study
調査の概要
状態
条件
詳細な説明
Before initiating the study, all potential subjects were invited to attend an educational program that explained the purpose and methodology of this study. After getting informed consent from patients, demographic data including age, sex, medical history (including comorbidities and risk factors), current medicine, lifestyle habits, height (cm), and weight (kg) were recorded, and body mass index (BMI) was calculated as weight divided by height squared (kilograms per square meter, kg/m2). The included subjects need to perform transthoracic echocardiography or provide an echocardiographic examination within one month. CAD diagnosis was determined based on the results of the coronary angiography, using stenosis 50% cutoffs considered have coronary diseases or not.
Consecutive patients of both sexes with coronary angiography from outpatient or inpatient departments of Fuwai Hospital were recruited into the study. The inclusion criteria were Chinese, aged 35 to 75 years with CAD verified by coronary angiography, and able to give informed written consent. The subjects were excluded if they had New York Heart Association Class III-IV degree with ejection fraction < 45%, severe pulmonary disease, significant psychiatric disease, or history of pharyngeal surgery for OSA or current use of CPAP treatment for OSA. They were also excluded if they declined to participate or were unable to provide informed consent.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Beijing、中国、100037
- Center of pulmonary vascular disease, Fuwai hospital
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- aged 35 to 75 years with CAD
- CAD was verified by coronary angiography
Exclusion Criteria:
- Patients had New York Heart Association Class III-IV degree with ejection fraction < 45%
- Severe pulmonary disease
- Significant psychiatric disease
- History of pharyngeal surgery for OSA or current use of CPAP treatment for OSA
- Subjects declined to participate or were unable to provide informed consent.
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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CAD with OSA
coronary artery disease with Obstructive sleep apnea
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CAD without OSA
coronary artery disease without Obstructive sleep apnea
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Association of apnea-hypopnea index (AHI) between obstructive sleep apnea and severity of coronary artery disease
時間枠:12 months
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The apnea-hypopnea index (AHI) was calculated as the total number of apneas and hypopneas occurring per hour of sleep.
And the severity of coronary artery disease was determined by Coronary angiography.
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12 months
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
The Prevalence of Obstructive Sleep Apnea in Coronary Artery Disease in China
時間枠:12 months
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The number of patients with Obstructive Sleep Apnea in Coronary Artery Disease in China
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12 months
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協力者と研究者
捜査官
- スタディチェア:Zhihong Liu, M.D、Fuwai Hospital
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
冠動脈疾患の臨床試験
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