Long-term Cancer Risk in the Randomised Oslo Diet and Antismoking Study
The Effect of Lifestyle Intervention on the Risk of Cancer - A Study of Participants in the Oslo Diet and Antismoking Study
調査の概要
詳細な説明
The Oslo diet and antismoking study showed that a 5-year lifestyle intervention reduced the long-term risk of coronary events and mortality. The lifestyle risk factors for cancer are partly similar to those for coronary heart disease, e.g. smoking, high body weight, unfavourable diet. The investigators therefore expect that the intervention has an effect on cancer risk in the long term.
In this follow-up study, the investigators analyse the association between the intervention, and cancer incidence and mortality drawn from the Cancer Registry of Norway and the Norwegian Cause of Death Registry from the time of randomisation in 1972/3 until the end of 2015.
研究の種類
入学 (実際)
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- participated in screening of coronary risk factors, into which all men born in 1923-1932 and living in Oslo were invited in 1972-1973
- being in the upper quartile of a coronary risk score based on blood pressure, serum total cholesterol concentration and cigarette smoking
Exclusion Criteria:
- serum total cholesterol level above 9.0 mmol per Liter
- having a healthy diet, based on a short dietary history
- self-reported cardiovascular disease or diabetes
- previous history of cancer
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
---|---|
コントロール
介入なし
|
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Diet and antismoking advice
Dietary and antismoking advice, aiming to reduce participant's risk of cardiovascular diseases
|
Dietary advice with the aim of reducing participant's serum cholesterol levels, including reduction in the intake of saturated fat and cholesterol, and increased intake of polyunsaturated fat, fish, vegetables and fruit.
Weight reduction was recommended for overweight men, as well as reduced consumption of sugar rich foods and drinks, and alcoholic beverages.
Smokers were advised to stop smoking.
The advice was given both individually and in group sessions during a five-year time period from 1972/3 until 1977/8.
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Incidence of the group of cancers related to smoking, diet or body mass index
時間枠:43 years
|
Diagnosis of carcinoma in the oral cavity, oropharynx, esophagus, stomach, colorectum, liver and intrahepatic bile ducts, pancreas, larynx, trachea, bronchus and lung, urinary tract and thyroid gland, drawn from the Cancer Registry of Norway
|
43 years
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Mortality in the group of cancers related to smoking, diet or body mass index
時間枠:43 years
|
Mortality in cancers in the oral cavity, oropharynx, esophagus, stomach, colorectum, liver and intrahepatic bile ducts, pancreas, larynx, trachea, bronchus and lung, urinary tract and thyroid gland, drawn from the Norwegian Cause of Death Registry
|
43 years
|
Cancer incidence
時間枠:43 years
|
Any cancer diagnosis, drawn from the Cancer Registry of Norway
|
43 years
|
Cancer mortality
時間枠:43 years
|
Mortality in any cancer, drawn from the Norwegian Cause of Death Registry
|
43 years
|
Incidence of gastrointestinal cancer
時間枠:43 years
|
Diagnosis of carcinoma in gastro-intestinal tract, drawn from the Cancer Registry of Norway
|
43 years
|
Incidence of lung cancer
時間枠:43 years
|
Diagnosis of carcinoma in lung, drawn from the Cancer Registry of Norway
|
43 years
|
Incidence of urinary tract cancer
時間枠:43 years
|
Diagnosis of carcinoma in urinary tract, drawn from the Cancer Registry of Norway
|
43 years
|
Incidence of prostate cancer
時間枠:43 years
|
Diagnosis of carcinoma in prostate, drawn from the Cancer Registry of Norway
|
43 years
|
協力者と研究者
スポンサー
捜査官
- 主任研究者:Paula Berstad, PhD、Cancer Registry of Norway
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
癌の臨床試験
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