Epidemiology, Treatment and Prognosis of Neonatal Meningitis in Turkey: A Multicenter Study (NEO-MENINGITIS)
Zekai Tahir Burak Women's Health Research and Education Hospital
Meningitis, defined as inflammation of the meninges caused by different pathogens, is a serious infection associated with high morbidity and mortality. It occurs more commonly in the neonatal period than in any other age group. Neonatal meningitis is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality. In this study, we aimed to evaluate epidemiology, treatment and prognosis of neonatal meningitis in a large-scale retrospective multicenter cohort study.
The main objectives of this study were to assess the incidence, temporal trend, risk factors, causative organisms, and short term outcomes of neonatal meningitis in a large national cohort of newborn infants admitted to Turkey NICUs.
調査の概要
状態
条件
研究の種類
入学 (予想される)
連絡先と場所
研究連絡先
- 名前：Mehmet Yekta Oncel, M.D.
- 電話番号：+902323394581
- メール：dryekta@gmail.com
研究連絡先のバックアップ
- 名前：Eda Karadag Oncel, M.D.
- 電話番号：+902324696969
- メール：dredakaradag@gmail.com
研究場所
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Ankara、七面鳥
- 募集
- Zekai Tahir Burak Women's Health Research and Education Hospital
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コンタクト：
- Fuat Emre Canpolat, M.D.
- 電話番号：+903123065000
- メール：femrecan@gmail.com
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Bursa、七面鳥
- 募集
- Bursa Yuksek Ihtisas Research and Education Hospital
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コンタクト：
- Mehmet Nevzat Cizmeci, M.D.
- 電話番号：+902242955000
- メール：nevzatcizmeci@gmail.com
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Diyarbakır、七面鳥
- 募集
- Gazi Yasargil Education Research Hospital
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コンタクト：
- Nilufer Okur, M.D.
- 電話番号：+904122519129
- メール：n.matur@hotmail.com
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İstanbul、七面鳥
- 募集
- Istanbul Kanuni Sultan Suleyman Training and Research Hospital
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コンタクト：
- Merih Cetinkaya, M.D.
- 電話番号：+902124041500
- メール：drmerih@yahoo.com
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İzmir、七面鳥、35590
- 募集
- Izmir Katip Celebi University, Medical Faculty
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コンタクト：
- Mehmet Yekta Oncel, MD
- 電話番号：+902323394581
- メール：dryekta@gmail.com
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
In this study,
- Lumbar puncture performed due to suspected meningitis and
- CSF laboratory findings are consistent with meningitis and
- Positivity in CSF culture and/or CSF PCR
Neonates hospitalized between 1 January 2014 and 31 May 2019 will be included in the study.
- The list of all cases diagnosed as on Neonatal Meningitis with growth in CSF culture and / or causative agent by CSF PCR will be obtained from the hospital's database.
- Term infants will be included in the study until 1 month and preterm infants will be adjusted until the first month.
説明
Inclusion Criteria:
- Subject has a positive cerebrospinal fluid culture/PCR of bacterial pathogen.
- Subject has a positive blood culture of bacterial pathogen and counts of white blood cells in cerebrospinal fluid ≥20 /mm3.
Exclusion Criteria:
- Major congenital anomalies
- Cultures positive for coagulase-negative staphylococci (CONS) were excluded as possible contaminants, if not clinically and laboratory compatible with meningitis.
研究計画
研究はどのように設計されていますか？
デザインの詳細
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Incidence of neonatal meningitis
時間枠：average of 5 years
|
Occurrence of a meningitis in NICU within a specified period of time.
(Number of neonatal meningitis cases / Total number of inpatients in the study period)
|
average of 5 years
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Causative organisms
時間枠：average of 5 years
|
Number and types of isolated microorganisms in CSF cultures
|
average of 5 years
|
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Neurodevelopmental Outcome
時間枠：18 to 24 months
|
- Bayley Scales of Infant Development, Second Edition (BSID II), was performed a comprehensive assessment including neurological and developmental evaluation.
The mean BSID II score is 100 for Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI), with a standard deviation (SD) of 15; a score of less than 70 (42 SDs below the mean) indicates a significant delay.
Infants who were so severely impaired that testing with the BSID II could not be performed were assigned a MDI and PDI score of 49.
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18 to 24 months
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Mortality
時間枠：up to 28 days
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Neonatal meningitis related mortality
|
up to 28 days
|
協力者と研究者
捜査官
- 主任研究者：Mehmet Yekta Oncel, M.D.、Tepecik Training and Research Hospital
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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