Prenatal Androgen and Skills
2026年5月30日 更新者：Rabia ZORLULAR、Nigde Omer Halisdemir University
Prenatal Androgen and Fine Motor Skills and Tactile Discrimination
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
調査の概要
詳細な説明
Sex hormones experienced during prenatal exposure play a significant role in shaping certain lifelong characteristics by influencing both the physical and neurological development of individuals.
The effects of these hormones, particularly on the developing nervous system, contribute to the emergence of behavioral and functional differences.
Hand preference and certain behavioral traits in humans have been shown to be related to prenatal hormonal exposure.
However, the development of these traits is not limited to hormonal influences alone, but is shaped by the interaction of genetic, environmental, and sociocultural factors.
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
However, whether the 2D:4D ratio is a reliable indicator of prenatal hormonal exposure is still a controversial issue in the literature.
Therefore, examining the relationship between the 2D:4D ratio and various biological and functional characteristics remains important.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
It is hypothesized that prenatal hormonal exposure may indirectly shape finger morphology and receptor distribution by affecting skin and nervous system development, which may be a determining factor in tactile sensitivity and dexterity.
研究の種類
観察的
入学 (推定)
94
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Merkez
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Niğde、Merkez、トルコ（Türkiye）
- Nigde Omer Halisdemir University
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
健康ボランティアの受け入れ
はい
サンプリング方法
非確率サンプル
調査対象母集団
- Healthy individuals aged 18-40
説明
Inclusion Criteria:
- Healthy individuals aged 18-40
- Having sufficient visual and auditory function to understand and administer the test,
- Voluntary agreement to participate in the study and providing informed consent.
Exclusion Criteria:
- Individuals with any musculoskeletal pathology,
- History of upper extremity trauma,
- Individuals diagnosed with metabolic, neurological, or genetic diseases,
- Individuals with a history of hand surgery within the last 6 months,
- Pregnancy or breastfeeding.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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Healthy adults
Young and healthy adults aged 18-40
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The second (2D) and fourth (4D) finger lengths of the participants will be measured separately in both hands by a physiotherapist with over thirteen years of clinical experience.
Hand dexterity will be assessed using the Purdue Pegboard Test.
The test will be administered according to standard procedure with participants seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within a specified time (30 seconds).
To perform the 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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2-point discrimination test
時間枠：12 months
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To perform 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
The test will begin at a distance of 8 mm, allowing participants to perceive the stimulus as two points, and then the distance will be gradually reduced.
After 5 mm, measurements will continue at 1 mm intervals.
In each application, both contact points will be applied to the skin simultaneously and with equal pressure, and participants will be asked to indicate whether the perceived stimulus is a single point or two points.
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12 months
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Digit Ratio
時間枠：12 months
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Measurements will be taken after participants' hands are placed on a flat surface with palms facing upwards. Finger length is defined as the distance from the midpoint of the proximal crease line where the finger joins the palm to the distal point of the fingertip. Measurements will be performed using a digital caliper with 0.01 mm accuracy, two separate measurements will be taken for each finger, and the average value will be recorded. Based on the obtained measurements, the 2D:4D finger ratio will be calculated by dividing the 2D length by the 4D length in both hands . |
12 months
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Fine motor skills
時間枠：12 months
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The test will be administered according to standard procedure while participants are seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within the specified time (30 seconds).
In the dominant and non-dominant hand tests, participants will be asked to place pegs with one hand for 30 seconds, while in the both-hand test, the simultaneous use of both hands will be evaluated.
The number of correctly placed pegs for each subtest will be recorded, and higher scores will be considered as better fine motor skill performance.
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12 months
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- 主任研究者：Rabia ZORLULAR、Nigde Omer Halisdemir University
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
- Butovskaya M, Adam Y, Batsevich V, Shackelford TK, Fink B. Associations between 2D:4D from direct and radiographic measurements with handgrip strength in young adult Tuvans. Early Hum Dev. 2024 Jun;193:106037. doi: 10.1016/j.earlhumdev.2024.106037. Epub 2024 May 8.
- Fink B, Manning JT, Neave N, Tan U. Second to fourth digit ratio and hand skill in Austrian children. Biol Psychol. 2004 Nov;67(3):375-84. doi: 10.1016/j.biopsycho.2004.03.012.
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (推定)
2026年7月1日
一次修了 (推定)
2027年7月1日
研究の完了 (推定)
2027年7月1日
試験登録日
最初に提出
2026年5月30日
QC基準を満たした最初の提出物
2026年5月30日
最初の投稿 (実際)
2026年6月4日
学習記録の更新
投稿された最後の更新 (実際)
2026年6月4日
QC基準を満たした最後の更新が送信されました
2026年5月30日
最終確認日
2026年5月1日
詳しくは
本研究に関する用語
その他の研究ID番号
- Androgen and Skills
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