Prenatal Androgen and Skills
30 mai 2026 mis à jour par: Rabia ZORLULAR, Nigde Omer Halisdemir University
Prenatal Androgen and Fine Motor Skills and Tactile Discrimination
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
Aperçu de l'étude
Statut
Inscription sur invitation
Les conditions
Intervention / Traitement
Description détaillée
Sex hormones experienced during prenatal exposure play a significant role in shaping certain lifelong characteristics by influencing both the physical and neurological development of individuals.
The effects of these hormones, particularly on the developing nervous system, contribute to the emergence of behavioral and functional differences.
Hand preference and certain behavioral traits in humans have been shown to be related to prenatal hormonal exposure.
However, the development of these traits is not limited to hormonal influences alone, but is shaped by the interaction of genetic, environmental, and sociocultural factors.
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
However, whether the 2D:4D ratio is a reliable indicator of prenatal hormonal exposure is still a controversial issue in the literature.
Therefore, examining the relationship between the 2D:4D ratio and various biological and functional characteristics remains important.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
It is hypothesized that prenatal hormonal exposure may indirectly shape finger morphology and receptor distribution by affecting skin and nervous system development, which may be a determining factor in tactile sensitivity and dexterity.
Type d'étude
Observationnel
Inscription (Estimé)
94
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Merkez
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Niğde, Merkez, Turquie (Türkiye)
- Nigde Omer Halisdemir University
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
- Adulte
Accepte les volontaires sains
Oui
Méthode d'échantillonnage
Échantillon non probabiliste
Population étudiée
- Healthy individuals aged 18-40
La description
Inclusion Criteria:
- Healthy individuals aged 18-40
- Having sufficient visual and auditory function to understand and administer the test,
- Voluntary agreement to participate in the study and providing informed consent.
Exclusion Criteria:
- Individuals with any musculoskeletal pathology,
- History of upper extremity trauma,
- Individuals diagnosed with metabolic, neurological, or genetic diseases,
- Individuals with a history of hand surgery within the last 6 months,
- Pregnancy or breastfeeding.
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
Intervention / Traitement |
|---|---|
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Healthy adults
Young and healthy adults aged 18-40
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The second (2D) and fourth (4D) finger lengths of the participants will be measured separately in both hands by a physiotherapist with over thirteen years of clinical experience.
Hand dexterity will be assessed using the Purdue Pegboard Test.
The test will be administered according to standard procedure with participants seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within a specified time (30 seconds).
To perform the 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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2-point discrimination test
Délai: 12 months
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To perform 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
The test will begin at a distance of 8 mm, allowing participants to perceive the stimulus as two points, and then the distance will be gradually reduced.
After 5 mm, measurements will continue at 1 mm intervals.
In each application, both contact points will be applied to the skin simultaneously and with equal pressure, and participants will be asked to indicate whether the perceived stimulus is a single point or two points.
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12 months
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Digit Ratio
Délai: 12 months
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Measurements will be taken after participants' hands are placed on a flat surface with palms facing upwards. Finger length is defined as the distance from the midpoint of the proximal crease line where the finger joins the palm to the distal point of the fingertip. Measurements will be performed using a digital caliper with 0.01 mm accuracy, two separate measurements will be taken for each finger, and the average value will be recorded. Based on the obtained measurements, the 2D:4D finger ratio will be calculated by dividing the 2D length by the 4D length in both hands . |
12 months
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Fine motor skills
Délai: 12 months
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The test will be administered according to standard procedure while participants are seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within the specified time (30 seconds).
In the dominant and non-dominant hand tests, participants will be asked to place pegs with one hand for 30 seconds, while in the both-hand test, the simultaneous use of both hands will be evaluated.
The number of correctly placed pegs for each subtest will be recorded, and higher scores will be considered as better fine motor skill performance.
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12 months
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Les enquêteurs
- Chercheur principal: Rabia ZORLULAR, Nigde Omer Halisdemir University
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Publications générales
- Butovskaya M, Adam Y, Batsevich V, Shackelford TK, Fink B. Associations between 2D:4D from direct and radiographic measurements with handgrip strength in young adult Tuvans. Early Hum Dev. 2024 Jun;193:106037. doi: 10.1016/j.earlhumdev.2024.106037. Epub 2024 May 8.
- Fink B, Manning JT, Neave N, Tan U. Second to fourth digit ratio and hand skill in Austrian children. Biol Psychol. 2004 Nov;67(3):375-84. doi: 10.1016/j.biopsycho.2004.03.012.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Estimé)
1 juillet 2026
Achèvement primaire (Estimé)
1 juillet 2027
Achèvement de l'étude (Estimé)
1 juillet 2027
Dates d'inscription aux études
Première soumission
30 mai 2026
Première soumission répondant aux critères de contrôle qualité
30 mai 2026
Première publication (Réel)
4 juin 2026
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
4 juin 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
30 mai 2026
Dernière vérification
1 mai 2026
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Androgen and Skills
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
NON
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Non
Étudie un produit d'appareil réglementé par la FDA américaine
Non
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .