Prenatal Androgen and Skills
30 maj 2026 uppdaterad av: Rabia ZORLULAR, Nigde Omer Halisdemir University
Prenatal Androgen and Fine Motor Skills and Tactile Discrimination
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
Studieöversikt
Status
Anmälan via inbjudan
Betingelser
Intervention / Behandling
Detaljerad beskrivning
Sex hormones experienced during prenatal exposure play a significant role in shaping certain lifelong characteristics by influencing both the physical and neurological development of individuals.
The effects of these hormones, particularly on the developing nervous system, contribute to the emergence of behavioral and functional differences.
Hand preference and certain behavioral traits in humans have been shown to be related to prenatal hormonal exposure.
However, the development of these traits is not limited to hormonal influences alone, but is shaped by the interaction of genetic, environmental, and sociocultural factors.
Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research.
In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement.
The 2D:4D ratio is generally lower in men than in women.
2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development.
However, whether the 2D:4D ratio is a reliable indicator of prenatal hormonal exposure is still a controversial issue in the literature.
Therefore, examining the relationship between the 2D:4D ratio and various biological and functional characteristics remains important.
To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited.
Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.
It is hypothesized that prenatal hormonal exposure may indirectly shape finger morphology and receptor distribution by affecting skin and nervous system development, which may be a determining factor in tactile sensitivity and dexterity.
Studietyp
Observationell
Inskrivning (Beräknad)
94
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
-
Merkez
-
Niğde, Merkez, Turkiet (Türkiye)
- Nigde Omer Halisdemir University
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
Tar emot friska volontärer
Ja
Testmetod
Icke-sannolikhetsprov
Studera befolkning
- Healthy individuals aged 18-40
Beskrivning
Inclusion Criteria:
- Healthy individuals aged 18-40
- Having sufficient visual and auditory function to understand and administer the test,
- Voluntary agreement to participate in the study and providing informed consent.
Exclusion Criteria:
- Individuals with any musculoskeletal pathology,
- History of upper extremity trauma,
- Individuals diagnosed with metabolic, neurological, or genetic diseases,
- Individuals with a history of hand surgery within the last 6 months,
- Pregnancy or breastfeeding.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
Kohorter och interventioner
Grupp / Kohort |
Intervention / Behandling |
|---|---|
|
Healthy adults
Young and healthy adults aged 18-40
|
The second (2D) and fourth (4D) finger lengths of the participants will be measured separately in both hands by a physiotherapist with over thirteen years of clinical experience.
Hand dexterity will be assessed using the Purdue Pegboard Test.
The test will be administered according to standard procedure with participants seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within a specified time (30 seconds).
To perform the 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
2-point discrimination test
Tidsram: 12 months
|
To perform 2-point discrimination tests, the Baseline® two-point discriminator will be used.
Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.
The test will begin at a distance of 8 mm, allowing participants to perceive the stimulus as two points, and then the distance will be gradually reduced.
After 5 mm, measurements will continue at 1 mm intervals.
In each application, both contact points will be applied to the skin simultaneously and with equal pressure, and participants will be asked to indicate whether the perceived stimulus is a single point or two points.
|
12 months
|
|
Digit Ratio
Tidsram: 12 months
|
Measurements will be taken after participants' hands are placed on a flat surface with palms facing upwards. Finger length is defined as the distance from the midpoint of the proximal crease line where the finger joins the palm to the distal point of the fingertip. Measurements will be performed using a digital caliper with 0.01 mm accuracy, two separate measurements will be taken for each finger, and the average value will be recorded. Based on the obtained measurements, the 2D:4D finger ratio will be calculated by dividing the 2D length by the 4D length in both hands . |
12 months
|
|
Fine motor skills
Tidsram: 12 months
|
The test will be administered according to standard procedure while participants are seated at a table.
Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within the specified time (30 seconds).
In the dominant and non-dominant hand tests, participants will be asked to place pegs with one hand for 30 seconds, while in the both-hand test, the simultaneous use of both hands will be evaluated.
The number of correctly placed pegs for each subtest will be recorded, and higher scores will be considered as better fine motor skill performance.
|
12 months
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Rabia ZORLULAR, Nigde Omer Halisdemir University
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Butovskaya M, Adam Y, Batsevich V, Shackelford TK, Fink B. Associations between 2D:4D from direct and radiographic measurements with handgrip strength in young adult Tuvans. Early Hum Dev. 2024 Jun;193:106037. doi: 10.1016/j.earlhumdev.2024.106037. Epub 2024 May 8.
- Fink B, Manning JT, Neave N, Tan U. Second to fourth digit ratio and hand skill in Austrian children. Biol Psychol. 2004 Nov;67(3):375-84. doi: 10.1016/j.biopsycho.2004.03.012.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Beräknad)
1 juli 2026
Primärt slutförande (Beräknad)
1 juli 2027
Avslutad studie (Beräknad)
1 juli 2027
Studieregistreringsdatum
Först inskickad
30 maj 2026
Först inskickad som uppfyllde QC-kriterierna
30 maj 2026
Första postat (Faktisk)
4 juni 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
4 juni 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
30 maj 2026
Senast verifierad
1 maj 2026
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- Androgen and Skills
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
NEJ
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Nej
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .