Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression
The Effect of Transcranial Magnetic Stimulation (TMS) Treatment on Defense Mechanisms and Functionality in Patients With Depression
This prospective observational study aims to evaluate changes in psychological defense mechanisms in patients with non-psychotic major depressive disorder (MDD) undergoing repetitive Transcranial Magnetic Stimulation (rTMS) therapy. The study investigates whether rTMS induces a shift from immature to more mature defense mechanisms and assesses how these changes relate to improvements in depressive symptom severity, anxiety levels, and overall functionality at baseline, 1-month, and 3-month follow-ups.
調査の概要
状態
条件
詳細な説明
Major depressive disorder (MDD) significantly impacts mood, cognitive function, and psychological defense structures. While repetitive Transcranial Magnetic Stimulation (rTMS) is an established non-invasive neuromodulation therapy for depression, its influence on psychodynamic constructs such as defense mechanisms remains insufficiently explored.
This single-center prospective study will enroll 50 adult participants (aged 18-65) diagnosed with non-psychotic MDD according to DSM-5 criteria (confirmed via SCID-5). Participants will receive rTMS treatment as part of their standard clinical care. Clinical assessments will be conducted by a blinded researcher at three time points: baseline (pre-treatment), 1 month, and 3 months post-baseline.
Primary outcomes will measure shifts in defense mechanism styles (mature, neurotic, immature) using the Defense Style Questionnaire (DSQ). Secondary outcomes will assess depressive symptom severity (Hamilton Depression Rating Scale - HAM-D), anxiety levels (Hamilton Anxiety Rating Scale - HAM-A), clinical severity and improvement (Clinical Global Impression Scale - CGI), and functional impairment (World Health Organization Disability Assessment Schedule 2.0 - WHODAS 2.0).
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Kardelen Erdoğan, MD
- 電話番号：+90 543 691 87 52
- メール：kardelenerdogan@nku.edu.tr
研究場所
-
-
-
Tekirdağ、トルコ（Türkiye）
- Tekirdağ Namik Kemal University Faculty of Medicine, Department of Psychiatry
-
コンタクト：
- kardeeln erdoğan, MD
- 電話番号：+90 543 691 87 52
- メール：kardelenerdogan@nku.edu.tr
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Adults aged 18-65 years with non-psychotic major depressive disorder (MDD) who are evaluated for suitability for transcranial magnetic stimulation (TMS) treatment at the Psychiatry Clinic/TMS Unit of Tekirdağ Namık Kemal University Hospital. The diagnosis of MDD will be confirmed using the Structured Clinical Interview for DSM Disorders (SCID). Approximately 50 participants who meet the eligibility criteria and provide written informed consent will be included.
説明
Inclusion Criteria:
- Age between 18 and 65 years
- Diagnosis of major depressive disorder without psychotic features according to DSM-5 criteria
- Confirmation of diagnosis via SCID
- Major depressive disorder as the primary reason for admission
- Willingness to participate and signing the written informed consent form
Exclusion Criteria:
- Presence of contraindications for TMS (e.g., metallic implants)
- Known active psychotic symptoms
- History of TMS treatment in the past 3 months
- Presence of known organic brain syndrome, neurological, or major systemic medical conditions
- Presence of known intellectual disability or significant cognitive impairment
- Active substance or alcohol use disorder
- Illiteracy
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：COHORT
- 時間の展望：PROSPECTIVE
コホートと介入
グループ/コホート |
|---|
|
TMS Treatment Group
Patients diagnosed with major depressive disorder receiving Transcranial Magnetic Stimulation therapy. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Defense Mechanisms (Defense Style Questionnaire - DSQ)
時間枠：Baseline, 1 month, and 3 months
|
Evaluates shifts in mature, neurotic, and immature psychological defense mechanism styles in patients with major depressive disorder following TMS treatment. |
Baseline, 1 month, and 3 months
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Anxiety Symptom Severity (Hamilton Anxiety Rating Scale - HAM-A)
時間枠：Baseline, 1 month and 3 months
|
Assesses psychic and somatic anxiety symptom severity. |
Baseline, 1 month and 3 months
|
|
Change in Depressive Symptom Severity (Hamilton Depression Rating Scale - HAM-D)
時間枠：Baseline, 1 month, and 3 months
|
Assesses the severity of depressive symptoms |
Baseline, 1 month, and 3 months
|
|
Change in Clinical Global Impression (CGI)
時間枠：Baseline, 1 month, and 3 months
|
Measures overall illness severity and clinical improvement. |
Baseline, 1 month, and 3 months
|
|
Change in Disability and Functionality (World Health Organization Disability Assessment Schedule 2.0 - WHODAS 2.0)
時間枠：Baseline, 1 month, and 3 months
|
Evaluates level of functional disability across six domains (understanding/communicating, mobility, self-care, getting along, life activities, participation). |
Baseline, 1 month, and 3 months
|
協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。