Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
2016년 3월 22일 업데이트: Centre Hospitalier Universitaire de Saint Etienne
Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm.
The directed forgetting paradigm is used, composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
연구 개요
상태
완전한
정황
상세 설명
Researchers used the directed forgetting paradigm composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
연구 유형
중재적
등록 (실제)
96
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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Saint Etienne, 프랑스, 42000
- Chu de Saint-Etienne
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 (성인)
건강한 자원 봉사자를 받아들입니다
예
연구 대상 성별
모두
설명
Inclusion Criteria for patients:
- Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
- Stabilized a therapeutic point of view for at least one month.
- Consent form signed
- Affiliated to a Security Health Program
Inclusion Criteria for volunteers:
- Consent form signed
- Affiliated to a Security Health Program
Exclusion Criteria for patients and volunteers :
- Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
- Not to use psychoactive substance, as defined by the DSM IV.
- The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
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실험적: Patients group 1
Memorization of the verbs by miming the action
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The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
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실험적: Patients group 2
Memorization of the verbs by imagining the action
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The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
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실험적: Patients group 3
Memorization of the action verbs by means of another word
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The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
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실험적: Patients group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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활성 비교기: Healthy volonteers group 1
Memorization of the verbs by miming the action
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The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
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활성 비교기: Healthy volonteers group 2
Memorization of the verbs by imagining the action
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The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
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활성 비교기: Healthy volonteers group 3
Memorization of the action verbs by means of another word
|
The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
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활성 비교기: Healthy volonteers group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Number of items recalled TBR and TBF
기간: Day 1
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It is asked to the participants to recall orally, only TBR verbs (task of reminder).
The experimenter notes the given verbs.
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Day 1
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Number of recognized items
기간: Day 1
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Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs. The recognition of a verb in the TBF list or a distractor is considered like an error. |
Day 1
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Reaction time (ms) on the recognition of TBR and TBF
기간: Day 1
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The response times of participants are recorded in ms.
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Day 1
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: Anne GROSSELIN, MD, Chu de Saint-Etienne
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작
2011년 5월 1일
기본 완료 (실제)
2012년 12월 1일
연구 완료 (실제)
2012년 12월 1일
연구 등록 날짜
최초 제출
2015년 8월 31일
QC 기준을 충족하는 최초 제출
2015년 8월 31일
처음 게시됨 (추정)
2015년 9월 2일
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
2016년 3월 23일
QC 기준을 충족하는 마지막 업데이트 제출
2016년 3월 22일
마지막으로 확인됨
2015년 8월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .