Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
22 mars 2016 mis à jour par: Centre Hospitalier Universitaire de Saint Etienne
Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm.
The directed forgetting paradigm is used, composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
Aperçu de l'étude
Statut
Complété
Les conditions
Description détaillée
Researchers used the directed forgetting paradigm composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
Type d'étude
Interventionnel
Inscription (Réel)
96
Phase
- N'est pas applicable
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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-
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Saint Etienne, France, 42000
- CHU de Saint-Etienne
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans à 50 ans (Adulte)
Accepte les volontaires sains
Oui
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria for patients:
- Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
- Stabilized a therapeutic point of view for at least one month.
- Consent form signed
- Affiliated to a Security Health Program
Inclusion Criteria for volunteers:
- Consent form signed
- Affiliated to a Security Health Program
Exclusion Criteria for patients and volunteers :
- Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
- Not to use psychoactive substance, as defined by the DSM IV.
- The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: Patients group 1
Memorization of the verbs by miming the action
|
The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
|
|
Expérimental: Patients group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
|
|
Expérimental: Patients group 3
Memorization of the action verbs by means of another word
|
The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
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Expérimental: Patients group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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|
Comparateur actif: Healthy volonteers group 1
Memorization of the verbs by miming the action
|
The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
|
|
Comparateur actif: Healthy volonteers group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
|
|
Comparateur actif: Healthy volonteers group 3
Memorization of the action verbs by means of another word
|
The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
|
|
Comparateur actif: Healthy volonteers group 4
Simple memorization of the verbs
|
The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Number of items recalled TBR and TBF
Délai: Day 1
|
It is asked to the participants to recall orally, only TBR verbs (task of reminder).
The experimenter notes the given verbs.
|
Day 1
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Number of recognized items
Délai: Day 1
|
Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs. The recognition of a verb in the TBF list or a distractor is considered like an error. |
Day 1
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Reaction time (ms) on the recognition of TBR and TBF
Délai: Day 1
|
The response times of participants are recorded in ms.
|
Day 1
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Les enquêteurs
- Chercheur principal: Anne GROSSELIN, MD, CHU de Saint-Etienne
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 mai 2011
Achèvement primaire (Réel)
1 décembre 2012
Achèvement de l'étude (Réel)
1 décembre 2012
Dates d'inscription aux études
Première soumission
31 août 2015
Première soumission répondant aux critères de contrôle qualité
31 août 2015
Première publication (Estimation)
2 septembre 2015
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
23 mars 2016
Dernière mise à jour soumise répondant aux critères de contrôle qualité
22 mars 2016
Dernière vérification
1 août 2015
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 1001156
- 2010-A01372-37 (Autre identifiant: ANSM)
Plan pour les données individuelles des participants (IPD)
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NON
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