Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
22 de marzo de 2016 actualizado por: Centre Hospitalier Universitaire de Saint Etienne
Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm.
The directed forgetting paradigm is used, composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
Descripción general del estudio
Estado
Terminado
Condiciones
Descripción detallada
Researchers used the directed forgetting paradigm composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
Tipo de estudio
Intervencionista
Inscripción (Actual)
96
Fase
- No aplica
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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-
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Saint Etienne, Francia, 42000
- CHU de Saint-Etienne
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
18 años a 50 años (Adulto)
Acepta Voluntarios Saludables
Sí
Géneros elegibles para el estudio
Todos
Descripción
Inclusion Criteria for patients:
- Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
- Stabilized a therapeutic point of view for at least one month.
- Consent form signed
- Affiliated to a Security Health Program
Inclusion Criteria for volunteers:
- Consent form signed
- Affiliated to a Security Health Program
Exclusion Criteria for patients and volunteers :
- Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
- Not to use psychoactive substance, as defined by the DSM IV.
- The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Experimental: Patients group 1
Memorization of the verbs by miming the action
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The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
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|
Experimental: Patients group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
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Experimental: Patients group 3
Memorization of the action verbs by means of another word
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The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
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Experimental: Patients group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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Comparador activo: Healthy volonteers group 1
Memorization of the verbs by miming the action
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The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
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Comparador activo: Healthy volonteers group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
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Comparador activo: Healthy volonteers group 3
Memorization of the action verbs by means of another word
|
The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
|
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Comparador activo: Healthy volonteers group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Number of items recalled TBR and TBF
Periodo de tiempo: Day 1
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It is asked to the participants to recall orally, only TBR verbs (task of reminder).
The experimenter notes the given verbs.
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Day 1
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Number of recognized items
Periodo de tiempo: Day 1
|
Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs. The recognition of a verb in the TBF list or a distractor is considered like an error. |
Day 1
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Reaction time (ms) on the recognition of TBR and TBF
Periodo de tiempo: Day 1
|
The response times of participants are recorded in ms.
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Day 1
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Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Anne GROSSELIN, MD, CHU de Saint-Etienne
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio
1 de mayo de 2011
Finalización primaria (Actual)
1 de diciembre de 2012
Finalización del estudio (Actual)
1 de diciembre de 2012
Fechas de registro del estudio
Enviado por primera vez
31 de agosto de 2015
Primero enviado que cumplió con los criterios de control de calidad
31 de agosto de 2015
Publicado por primera vez (Estimar)
2 de septiembre de 2015
Actualizaciones de registros de estudio
Última actualización publicada (Estimar)
23 de marzo de 2016
Última actualización enviada que cumplió con los criterios de control de calidad
22 de marzo de 2016
Última verificación
1 de agosto de 2015
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 1001156
- 2010-A01372-37 (Otro identificador: ANSM)
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
NO
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