Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
2016年3月22日 更新者:Centre Hospitalier Universitaire de Saint Etienne
Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm.
The directed forgetting paradigm is used, composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
研究概览
地位
完全的
条件
详细说明
Researchers used the directed forgetting paradigm composed of two lists of action verbs.
The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug.
Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)).
A recognition task is performed at the end.
The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only.
48 schizophrenic patients were included in this study.
Patients were randomized to have 10 participants per condition.
48 controls matched by age, gender, laterality and education are also included and randomized in the same modality.
This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.
研究类型
介入性
注册 (实际的)
96
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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-
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Saint Etienne、法国、42000
- CHU de Saint-Etienne
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-
参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 50年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria for patients:
- Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
- Stabilized a therapeutic point of view for at least one month.
- Consent form signed
- Affiliated to a Security Health Program
Inclusion Criteria for volunteers:
- Consent form signed
- Affiliated to a Security Health Program
Exclusion Criteria for patients and volunteers :
- Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
- Not to use psychoactive substance, as defined by the DSM IV.
- The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的:Patients group 1
Memorization of the verbs by miming the action
|
The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
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实验性的:Patients group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
|
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实验性的:Patients group 3
Memorization of the action verbs by means of another word
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The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
|
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实验性的:Patients group 4
Simple memorization of the verbs
|
The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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有源比较器:Healthy volonteers group 1
Memorization of the verbs by miming the action
|
The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
|
|
有源比较器:Healthy volonteers group 2
Memorization of the verbs by imagining the action
|
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
|
|
有源比较器:Healthy volonteers group 3
Memorization of the action verbs by means of another word
|
The participant reads aloud the verbs that appear on the screen.
Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one.
The word is written near the action verb.
|
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有源比较器:Healthy volonteers group 4
Simple memorization of the verbs
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The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Number of items recalled TBR and TBF
大体时间:Day 1
|
It is asked to the participants to recall orally, only TBR verbs (task of reminder).
The experimenter notes the given verbs.
|
Day 1
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Number of recognized items
大体时间:Day 1
|
Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs. The recognition of a verb in the TBF list or a distractor is considered like an error. |
Day 1
|
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Reaction time (ms) on the recognition of TBR and TBF
大体时间:Day 1
|
The response times of participants are recorded in ms.
|
Day 1
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员:Anne GROSSELIN, MD、CHU de Saint-Etienne
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2011年5月1日
初级完成 (实际的)
2012年12月1日
研究完成 (实际的)
2012年12月1日
研究注册日期
首次提交
2015年8月31日
首先提交符合 QC 标准的
2015年8月31日
首次发布 (估计)
2015年9月2日
研究记录更新
最后更新发布 (估计)
2016年3月23日
上次提交的符合 QC 标准的更新
2016年3月22日
最后验证
2015年8月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.