이전에 치료받은 비편평 비소세포폐암(NSCLC) 성인 참가자에서 IV 도세탁셀과 비교하여 정맥(IV) Telisotuzumab Vedotin의 질병 활동 및 부작용을 평가하기 위한 연구
2026년 10월 27일 업데이트: AbbVie
이전에 치료받은 c-Met 과발현, EGFR 야생형, 국소 진행성/전이성 비편평 비소세포폐암 대상자를 대상으로 텔리소투주맙 베도틴(ABBV-399) 대 도세탁셀의 3상 공개, 무작위, 통제, 글로벌 연구
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to determine if telisotuzumab vedotin works better than docetaxel and to assess how safe telisotuzumab vedotin is in adult participants with NSCLC who have previously been treated. Change in disease activity and adverse events will be assessed.
Telisotuzumab vedotin is an investigational drug being developed for the treatment of NSCLC. Participants will be randomly assigned a treatment of telisotuzumab vedotin or docetaxel at an 1:1 ratio. Each group receives intravenous (IV) infusion of telisotuzumab vedotin or IV infusion of docetaxel. Approximately 768 adult participants with c-Met overexpressing NSCLC will be enrolled in the study in approximately 330 sites worldwide.
Participants will receive IV telisotuzumab vedotin every 2 weeks or docetaxel every 3 weeks until meeting study drug discontinuation criteria. At the conclusion of the study, participants who continue to demonstrate clinical benefit may be eligible to receive study treatment via an extension of the study, a rollover study, or through another mechanism.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
연구 개요
연구 유형
중재적
등록 (추정된)
768
단계
- 3단계
확장된 액세스
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확장 액세스 기록을 참조하세요.
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: ABBVIE CALL CENTER
- 전화번호: 844-663-3742
- 이메일: abbvieclinicaltrials@abbvie.com
연구 장소
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Thessaloniki, 그리스, 57001
- 완전한
- Interbalkan Medical Center Of Thessaloniki /ID# 254407
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Attica
-
Athens, Attica, 그리스, 11526
- 모병
- Henry Dunnant Hospital Center /ID# 267021
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Athens, Attica, 그리스, 11527
- 모병
- Thoracic General Hospital of Athens I Sotiria /ID# 230824
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Piraeus, Attica, 그리스, 18547
- 모병
- Metropolitan Hospital /ID# 232158
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Piraeus, Attica, 그리스, 18547
- 모병
- Metropolitan Hospital /ID# 239170
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-
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Gauteng
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Johannesburg, Gauteng, 남아프리카, 2196
- 완전한
- Sandton Oncology Medical Group PTY Ltd /ID# 230843
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Johannesburg, Gauteng, 남아프리카, 1864
- 완전한
- Wits Clinical Research /ID# 230841
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Pretoria, Gauteng, 남아프리카, 0001
- 모병
- Steve Biko Academic Hospital /ID# 230883
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's-Hertogenbosch, 네덜란드, 5223 GZ
- 모병
- Jeroen Bosch Ziekenhuis /ID# 234087
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Gelderland
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Harderwijk, Gelderland, 네덜란드, 3844 DG
- 모병
- Ziekenhuis St. Jansdal /ID# 251932
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Limburg
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Maastricht, Limburg, 네덜란드, 6229 HX
- 모병
- Maastricht Universitair Medisch Centrum /ID# 233932
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Overijssel
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Zwolle, Overijssel, 네덜란드, 8025 AB
- 모병
- Isala /ID# 238846
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South Holland
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The Hague, South Holland, 네덜란드, 2545 AA
- 모병
- HagaZiekenhuis /ID# 243693
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-
-
-
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Changhua City, Changhua County, 대만, 50006
- 모병
- Changhua Christian Hospital /ID# 238394
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Hsinchu, 대만, 30059
- 모병
- National Taiwan University Hospital - Hsinchu branch /ID# 238393
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Hualien City, 대만, 97002
- 모병
- Hualien Tzu Chi Hospital /ID# 238398
-
Taichung, 대만, 402
- 모병
- Chung Shan Medical University Hospital /ID# 238444
-
Taipei, 대만, 104
- 모병
- Mackay Memorial Hospital /ID# 238392
-
Taipei, 대만, 11031
- 모병
- Taipei Medical University Hospital /ID# 238380
-
Taipei, 대만, 100
- 모병
- National Taiwan University Hospital /ID# 238378
-
-
Kaohsiung
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Kaohsiung City, Kaohsiung, 대만, 82445
- 모병
- E-DA Cancer Hospital /ID# 239718
-
-
-
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Gyeonggido
-
Goyang-si, Gyeonggido, 대한민국, 10408
- 모병
- National Cancer Center /ID# 260663
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Seongnam, Gyeonggido, 대한민국, 13496
- 모병
- CHA Bundang Medical Center /ID# 233318
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Suwon, Gyeonggido, 대한민국, 16247
- 모병
- The Catholic University Of Korea St. Vincent's Hospital /ID# 256942
-
Suwon, Gyeonggido, 대한민국, 16499
- 모병
- Ajou University Hospital - Suwon-si /ID# 233319
-
-
Gyeongsangnam-do
-
Jinju, Gyeongsangnam-do, 대한민국, 52727
- 모병
- Gyeongsang National University Hospital /ID# 234244
-
Yangsan, Gyeongsangnam-do, 대한민국, 50612
- 모병
- Pusan National University Yangsan Hospital /ID# 257836
-
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North Chungcheong
-
Cheongju-si, North Chungcheong, 대한민국, 28644
- 모병
- Chungbuk National University Hospital /ID# 257891
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연락하다:
- Site Coordinator
- 전화번호: 043-261-3703
-
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Seoul Teugbyeolsi
-
Seoul, Seoul Teugbyeolsi, 대한민국, 03181
- 모병
- Kangbuk Samsung Hospital /ID# 233711
-
Seoul, Seoul Teugbyeolsi, 대한민국, 06351
- 모병
- Samsung Medical Center /ID# 256941
-
Seoul, Seoul Teugbyeolsi, 대한민국, 07061
- 모병
- SMG-SNU Boramae Medical Center /ID# 233710
-
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-
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Region Sjælland
-
Køge, Region Sjælland, 덴마크, 4600
- 모병
- Zealand University Hospital /ID# 241842
-
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Region Syddanmark
-
Odense, Region Syddanmark, 덴마크, 5000
- 모병
- Odense University Hospital /ID# 241663
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-
-
-
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Berlin, 독일, 13353
- 모병
- Charite Universitaetsmedizin Berlin Campus Virchow-Klinikum /ID# 234247
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Hamburg, 독일, 20251
- 모병
- Haemato-Onkologie Hamburg /ID# 241047
-
Hamburg, 독일, 20246
- 모병
- Universitaetsklinikum Hamburg-Eppendorf /ID# 239658
-
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Baden-Wurttemberg
-
Heidelberg, Baden-Wurttemberg, 독일, 69126
- 모병
- Thoraxklinik Heidelberg gGmbH /ID# 239656
-
Mannheim, Baden-Wurttemberg, 독일, 68167
- 모병
- Universitatsklinikum Mannheim /ID# 238331
-
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Bavaria
-
Gauting, Bavaria, 독일, 82131
- 모병
- Asklepios Fachkliniken Muenchen-Gauting /ID# 272768
-
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Hesse
-
Giessen, Hesse, 독일, 35392
- 모병
- Universitaetsklinikum Giessen /ID# 252973
-
Kassel, Hesse, 독일, 34125
- 모병
- Klinikum Kassel /ID# 240142
-
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Saxony
-
Dresden, Saxony, 독일, 01307
- 모병
- Universitaetsklinikum Carl Gustav Carus Dresden /ID# 274719
-
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Thuringia
-
Bad Berka, Thuringia, 독일, 99437
- 모병
- Zentralklinik Bad Berka /ID# 239661
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-
-
-
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Brasov, 루마니아, 500283
- 모병
- Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 240826
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Iași, 루마니아, 700483
- 모병
- Institutul Regional de Oncologie /ID# 254065
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Suceava, 루마니아, 720214
- 모병
- S.C. Sigmedical Services SRL /ID# 239108
-
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Bihor County
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Oradea, Bihor County, 루마니아, 410469
- 모병
- Spitalul Pelican /ID# 254066
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Cluj
-
Cluj-Napoca, Cluj, 루마니아, 400015
- 모병
- Cardiomed Srl /Id# 255320
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Dolj
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Craiova, Dolj, 루마니아, 200385
- 모병
- Sc Oncolab Srl /Id# 239105
-
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Ilfov
-
Otopeni, Ilfov, 루마니아, 075100
- 모병
- SC RTC Radiology Therapeutic Center SRL /ID# 240744
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Timiș County
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Timișoara, Timiș County, 루마니아, 300166
- 모병
- Oncocenter - Oncologie Clinica Srl /Id# 239103
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-
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Oaxaca City, 멕시코, 68020
- 모병
- Clinical Research & Oncology Oaxaca /ID# 231883
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Jalisco
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Guadalajara, Jalisco, 멕시코, 44280
- 모병
- O.P.D. Hospital Civil de Guadalajara /ID# 238488
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Michoacán
-
Morelia, Michoacán, 멕시코, 58260
- 완전한
- Centro de Investigacion Clínica Chapultepec SA de CV /ID# 231928
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-
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Alabama
-
Birmingham, Alabama, 미국, 35233
- 완전한
- University of Alabama at Birmingham - Main /ID# 247074
-
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Arizona
-
Chandler, Arizona, 미국, 85224-5665
- 모집하지 않고 적극적으로
- Ironwood Cancer & Res Ctr /ID# 262446
-
Phoenix, Arizona, 미국, 85054-4504
- 모집하지 않고 적극적으로
- Mayo Clinic Arizona /ID# 255858
-
Yuma, Arizona, 미국, 85364
- 완전한
- Onvida Health Yuma Medical Center /ID# 253625
-
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California
-
Duarte, California, 미국, 91010
- 모병
- City of Hope /ID# 243157
-
Huntington Beach, California, 미국, 92648
- 모병
- City Of Hope - Seacliff /ID# 263143
-
Irvine, California, 미국, 92618
- 모병
- City of Hope - Orange County Lennar Foundation Cancer Center /ID# 263144
-
Lancaster, California, 미국, 93534
- 모병
- City Of Hope - Antelope Valley /ID# 263138
-
Los Angeles, California, 미국, 90033
- 완전한
- The Oncology Institute Of Hope & Innovation -East Los A /ID# 239774
-
Rancho Mirage, California, 미국, 92270-3221
- 완전한
- Eisenhower Medical Center /ID# 233189
-
Santa Monica, California, 미국, 90404
- 완전한
- Premiere Oncology Foundation /ID# 253954
-
-
Florida
-
Jacksonville, Florida, 미국, 32224
- 완전한
- Mayo Clinic Hospital Jacksonville /ID# 254688
-
Ocala, Florida, 미국, 34474-4445
- 완전한
- Ocala Oncology Florida Cancer Affiliates - Main /ID# 234228
-
Tamarac, Florida, 미국, 33321-2919
- 완전한
- BRCR Medical Center Inc /ID# 262344
-
-
Georgia
-
Savannah, Georgia, 미국, 31404
- 완전한
- Memorial University Medical Center /ID# 264081
-
-
Hawaii
-
Honolulu, Hawaii, 미국, 96819-1469
- 모병
- Kaiser Permanente Moanalua Medical Center /ID# 238363
-
-
Illinois
-
Elmhurst, Illinois, 미국, 60126
- 모집하지 않고 적극적으로
- Edward-Elmhurst Cancer Center /ID# 238552
-
Springfield, Illinois, 미국, 62702
- 모집하지 않고 적극적으로
- Springfield Clinic - First /ID# 262290
-
-
Indiana
-
Goshen, Indiana, 미국, 46526
- 완전한
- Goshen Center for Cancer Care /ID# 257734
-
Indianapolis, Indiana, 미국, 46260
- 완전한
- Investigative Clinical Research of Indiana - Indianapolis /ID# 260468
-
-
Kentucky
-
Lexington, Kentucky, 미국, 40503
- 완전한
- Baptist Health Lexington /ID# 252769
-
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Massachusetts
-
Boston, Massachusetts, 미국, 02215
- 완전한
- Dana-Farber Cancer Institute /ID# 247132
-
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Michigan
-
Ypsilanti, Michigan, 미국, 48197-1051
- 완전한
- Trinity Health St. Joseph Mercy Ann Arbor /ID# 232190
-
-
Minnesota
-
Rochester, Minnesota, 미국, 55905
- 모집하지 않고 적극적으로
- Mayo Clinic Hospital Rochester /ID# 252052
-
-
Mississippi
-
Hattiesburg, Mississippi, 미국, 39401
- 모병
- Hattiesburg Clinic /ID# 248033
-
-
Missouri
-
Chesterfield, Missouri, 미국, 63017
- 완전한
- St. Luke's Hospital - Chesterfield /ID# 251688
-
Kansas City, Missouri, 미국, 64114-4859
- 완전한
- Alliance for Multispecialty Research (AMR) - Kansas City /ID# 247567
-
Kansas City, Missouri, 미국, 64111
- 모병
- St. Lukes Hosp. of Kansas City /ID# 259940
-
Springfield, Missouri, 미국, 65807-5287
- 모병
- Hulston Cancer Center /ID# 232226
-
St Louis, Missouri, 미국, 63110-2539
- 완전한
- Saint Louis University Cancer Center /ID# 260722
-
-
Montana
-
Billings, Montana, 미국, 59102
- 모집하지 않고 적극적으로
- Intermountain Health St Vincent Regional Hospital - Cancer Centers of Montana /ID# 253147
-
-
Nebraska
-
Lincoln, Nebraska, 미국, 68506
- 완전한
- Nebraska Hematology Oncology /ID# 257710
-
-
Nevada
-
Reno, Nevada, 미국, 89502-1464
- 완전한
- Renown Medical Group - Oncology/Hematology /ID# 247942
-
-
New Jersey
-
East Brunswick, New Jersey, 미국, 08816-4096
- 완전한
- Astera Cancer Care /ID# 257753
-
-
New Mexico
-
Farmington, New Mexico, 미국, 87401
- 완전한
- San Juan Oncology Associates /ID# 244387
-
-
New York
-
Brooklyn, New York, 미국, 11219
- 모집하지 않고 적극적으로
- Maimonides Medical Center /ID# 240783
-
Lake Success, New York, 미국, 11042
- 완전한
- Northwell Health - Monter Cancer Center /ID# 247081
-
-
North Carolina
-
Hendersonville, North Carolina, 미국, 28792
- 완전한
- AdventHealth Hendersonville /ID# 265349
-
Pinehurst, North Carolina, 미국, 28374
- 완전한
- FirstHealth of the Carolinas- Speciality Center /ID# 241279
-
-
Ohio
-
Zanesville, Ohio, 미국, 43701-1406
- 모집하지 않고 적극적으로
- Genesis Cancer Care Center /ID# 239190
-
-
Pennsylvania
-
York, Pennsylvania, 미국, 17403
- 완전한
- Cancer Care Associates Of York /ID# 266143
-
-
South Carolina
-
Charleston, South Carolina, 미국, 29425
- 완전한
- Medical University of South Carolina /ID# 251383
-
Greenville, South Carolina, 미국, 29607-5253
- 완전한
- St Francis Cancer Center /ID# 243596
-
-
South Dakota
-
Aberdeen, South Dakota, 미국, 57401
- 완전한
- Avera Cancer Institute - Aberdeen /ID# 257759
-
Sioux Falls, South Dakota, 미국, 57105
- 완전한
- Avera Cancer Institute /ID# 239635
-
-
Tennessee
-
Memphis, Tennessee, 미국, 38104
- 완전한
- Duplicate_Memphis VA Medical Center /ID# 263250
-
-
Texas
-
Austin, Texas, 미국, 78701
- 모집하지 않고 적극적으로
- Dell Seton Medical Center /ID# 247016
-
-
Utah
-
Ogden, Utah, 미국, 84405-7194
- 완전한
- Community Cancer Trials of Utah - South Ogden /ID# 262829
-
-
Washington
-
Renton, Washington, 미국, 98055-5738
- 모병
- Valley Medical Center /ID# 253950
-
Spokane, Washington, 미국, 99208
- 완전한
- Medical Oncology Associates /ID# 247003
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-
-
-
-
Anderlecht, 벨기에, 1070
- 모병
- Institut Jules Bordet /ID# 246770
-
Ghent, 벨기에, 9000
- 모병
- AZ Maria Middelares /ID# 246768
-
Liège, 벨기에, 4000
- 모병
- CHU de Liege /ID# 246772
-
Namur, 벨기에, 5000
- 모병
- UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 246769
-
-
Antwerpen
-
Brasschaat, Antwerpen, 벨기에, 2930
- 모병
- Algemeen Ziekenhuis klina /ID# 239853
-
Edegem, Antwerpen, 벨기에, 2650
- 모병
- Universitair Ziekenhuis Antwerpen /ID# 239971
-
-
Hainaut
-
Charleroi, Hainaut, 벨기에, 6280
- 모병
- Grand Hopital de Charleroi - Les Viviers /ID# 234178
-
La Louvière, Hainaut, 벨기에, 7100
- 모병
- Hospital La Louviere Site Jolimont - Helora /ID# 246771
-
-
Limburg
-
Hasselt, Limburg, 벨기에, 3500
- 모병
- Jessa Ziekenhuis /ID# 246766
-
-
Oost-Vlaanderen
-
Ghent, Oost-Vlaanderen, 벨기에, 9000
- 모병
- UZ Gent /ID# 273244
-
Sint-Niklaas, Oost-Vlaanderen, 벨기에, 9100
- 모병
- Vitaz /Id# 246773
-
-
-
-
-
Burgas, 불가리아, 8000
- 완전한
- Complex Oncology Center - Burgas /ID# 240532
-
Plovdiv, 불가리아, 4004
- 모병
- Complex Cancer Center Plovdiv /ID# 234106
-
Varna, 불가리아, 9009
- 모병
- UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 234112
-
-
Pazardzhik
-
Panagyurishte, Pazardzhik, 불가리아, 4500
- 모병
- Uni Hospital /ID# 273707
-
-
Sofia
-
Sofiya, Sofia, 불가리아, 1797
- 모병
- University Multiprofile Hospital for Active Treatment Sofiamed /ID# 234108
-
-
-
-
-
Rio de Janeiro, 브라질, 20231-050
- 모병
- Instituto Nacional de Cancer (INCA) /ID# 231509
-
Rio de Janeiro, 브라질, 22281-100
- 모병
- Instituto Dor de Pesquisa e Ensino /ID# 233245
-
São Paulo, 브라질, 01236-030
- 모병
- Instituto de Ensino e Pesquisas Sao Lucas /ID# 247417
-
São Paulo, 브라질, 08270-070
- 모병
- Casa de Saúde Santa Marcelina /ID# 231605
-
São Paulo, 브라질, 01308-050
- 모병
- Hospital Sirio Libanes - Sao Paulo /ID# 261827
-
-
Estado de Bahia
-
Salvador, Estado de Bahia, 브라질, 41950-640
- 모병
- Clinica Amo - Rio Vermelho /ID# 231604
-
-
Rio Grande do Sul
-
Porto Alegre, Rio Grande do Sul, 브라질, 90020-090
- 모병
- Hospital Da Crianca Santo Antonio /ID# 233249
-
-
São Paulo
-
Barretos, São Paulo, 브라질, 14784-400
- 모병
- Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 233247
-
São Paulo, São Paulo, 브라질, 05874-230
- 모병
- OC Oncoclínicas SP /ID# 261828
-
-
-
-
Stockholm County
-
Solna, Stockholm County, 스웨덴, 171 64
- 모병
- Karolinska University Hospital Solna /ID# 229853
-
-
Västra Götaland County
-
Gothenburg, Västra Götaland County, 스웨덴, 413 46
- 모병
- Sahlgrenska Universitetssjukhuset /ID# 229943
-
-
-
-
-
Barcelona, 스페인, 08017
- 모병
- UOMi Cancer Center - Clinica Tres Torres /ID# 240584
-
Barcelona, 스페인, 08028
- 모병
- Hospital Universitario Dexeus - Grupo Quironsalud /ID# 255105
-
Jaén, 스페인, 23007
- 모병
- Hospital Universitario de Jaen /ID# 240588
-
Madrid, 스페인, 28041
- 모병
- Hospital Universitario 12 de Octubre /ID# 240176
-
Valencia, 스페인, 46010
- 모병
- Hospital Clinico Universitario de Valencia /ID# 240378
-
Ávila, 스페인, 05004
- 모병
- Hospital Nuestra Senora de Sonsoles /ID# 255102
-
-
Las Palmas
-
Las Palmas de Gran Canaria, Las Palmas, 스페인, 35016
- 모병
- CHU Insular-Materno Infantil /ID# 255094
-
-
Madrid
-
Alcorcón, Madrid, 스페인, 28922
- 모병
- Hospital Universitario Fundacion Alcorcon /ID# 255100
-
Fuenlabrada, Madrid, 스페인, 28942
- 모병
- Hospital Universitario de Fuenlabrada /ID# 255093
-
-
-
-
Banská Bystrica Region
-
Banská Bystrica, Banská Bystrica Region, 슬로바키아, 975 17
- 완전한
- Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 230084
-
-
-
-
-
Buenos Aires, 아르헨티나, 1125
- 모병
- LC Investigacion /ID# 239880
-
Buenos Aires, 아르헨티나, 1417
- 모병
- Instituto de Oncologia Angel H Roffo /ID# 231499
-
연락하다:
- Site Coordinator
- 전화번호: 5491141689984
-
-
Buenos Aires
-
Ciudad Autonoma Buenos Aires, Buenos Aires, 아르헨티나, 1431
- 모병
- Cemic /Id# 231486
-
Ciudad Autonoma de Buenos Aire, Buenos Aires, 아르헨티나, 1280
- 모병
- Hospital Britanico de Buenos Aires /ID# 231495
-
-
Buenos Aires F.D.
-
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., 아르헨티나, 1019
- 모병
- Centro Médico Austral /ID# 239860
-
-
Río Negro Province
-
Viedma, Río Negro Province, 아르헨티나, 8500
- 모병
- Centro de Investigaciones Clinicas Clinica Viedma S.A. /ID# 232339
-
-
-
-
-
London, 영국, SW3 6JJ
- 모병
- The Royal Marsden NHS Foundation Trust /ID# 246974
-
Manchester, 영국, M20 4BX
- 모병
- The Christie Hospital /ID# 243422
-
-
Greater London
-
London, Greater London, 영국, NW1 2BU
- 모병
- UCLH NHS FT - University College Hospital /ID# 249407
-
London, Greater London, 영국, EC1A 7BE
- 모병
- St Bartholomews Hospital - Barts Health /ID# 254342
-
-
Nottinghamshire
-
Nottingham, Nottinghamshire, 영국, NG5 1PB
- 모병
- Nottingham City Hospital /ID# 254707
-
-
West Midlands
-
Birmingham, West Midlands, 영국, B9 5SS
- 모병
- Heartlands Hospital - University Hospitals Birmingham /ID# 258141
-
-
-
-
-
Salzburg, 오스트리아, 5020
- 모병
- Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 232467
-
-
State of Vienna
-
Vienna, State of Vienna, 오스트리아, 1090
- 모병
- Medizinische Universitaet Wien /ID# 230615
-
Vienna, State of Vienna, 오스트리아, 1140
- 모병
- Klinik Penzing /ID# 230700
-
Vienna, State of Vienna, 오스트리아, 1210
- 모병
- Klinik Floridsdorf /ID# 230608
-
-
Tyrol
-
Innsbruck, Tyrol, 오스트리아, 6020
- 모병
- Medizinische Universitaet Innsbruck /ID# 240981
-
연락하다:
- Site Coordinator
- 전화번호: 004351290030
-
-
Upper Austria
-
Linz, Upper Austria, 오스트리아, 4010
- 모병
- Ordensklinikum Linz Elisabethinen /ID# 240967
-
Wels, Upper Austria, 오스트리아, 4600
- 모병
- Klinikum Wels-Grieskirchen Gmbh /ID# 249000
-
-
Vorarlberg
-
Feldkirch, Vorarlberg, 오스트리아, 6800
- 모병
- Landeskrankenhaus Feldkirch /ID# 250333
-
-
-
-
Northern District
-
Safed, Northern District, 이스라엘, 13100
- 모병
- ZIV Medical Center /ID# 238606
-
-
Southern District
-
Beersheba, Southern District, 이스라엘, 8410101
- 모병
- Soroka University Medical Center /ID# 252711
-
Holon, Southern District, 이스라엘, 5822000
- 완전한
- The Edith Wolfson Medical Center /ID# 233781
-
-
Tel Aviv
-
Tel Aviv, Tel Aviv, 이스라엘, 6423906
- 모병
- Tel Aviv Sourasky Medical Center /ID# 260519
-
-
-
-
-
Bari, 이탈리아, 70124
- 모병
- I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 238696
-
Cremona, 이탈리아, 26100
- 모병
- Azienda Socio Sanitaria Territoriale di Cremona /ID# 238698
-
Messina, 이탈리아, 98158
- 완전한
- Azienda Ospedaliera Papardo /ID# 258038
-
Perugia, 이탈리아, 06156
- 모병
- Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 238473
-
Varese, 이탈리아, 21100
- 모병
- ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 238536
-
-
Catania
-
Misterbianco, Catania, 이탈리아, 95045
- 모병
- Humanitas Istituto Clinico Catanese /ID# 273050
-
-
Milano
-
Milan, Milano, 이탈리아, 20132
- 모병
- IRCCS Ospedale San Raffaele /ID# 254376
-
-
Napoli
-
Naples, Napoli, 이탈리아, 80138
- 모병
- Azienda Ospedaliera Universitaria Luigi Vanvitelli - Miraglia /ID# 252942
-
-
Roma
-
Rome, Roma, 이탈리아, 00184
- 모병
- Azienda Ospedaliera Complesso Ospedaliero San Giovanni-Addolorata /ID# 238618
-
-
-
-
-
Fukushima, 일본, 960-1295
- 모병
- Fukushima Medical University Hospital /ID# 249691
-
-
Aichi-ken
-
Nagoya, Aichi-ken, 일본, 460-0001
- 모병
- NHO Nagoya Medical Center /ID# 246306
-
Nagoya, Aichi-ken, 일본, 466-8560
- 모병
- Nagoya University Hospital /ID# 239990
-
-
Aomori
-
Hirosaki-shi, Aomori, 일본, 036-8203
- 모병
- Hirosaki University Hospital /ID# 242377
-
-
Chiba
-
Kashiwa-shi, Chiba, 일본, 277-8577
- 모병
- National Cancer Center Hospital East /ID# 233775
-
-
Fukuoka
-
Fukuoka, Fukuoka, 일본, 810-8563
- 모병
- National Hospital Organization Kyushu Medical Center /ID# 238533
-
Kitakyushu-shi, Fukuoka, 일본, 807-8556
- 모병
- Hospital Of The University Of Occupational And Environmental Health, Japan /ID# 241191
-
Kurume-shi, Fukuoka, 일본, 830-0011
- 모병
- Kurume University Hospital /ID# 254900
-
-
Gunma
-
Ota-shi, Gunma, 일본, 373-8550
- 모병
- Gunma Prefectural Cancer Center /ID# 233723
-
-
Hiroshima
-
Fukuyama, Hiroshima, 일본, 720-0001
- 모병
- Chugoku Central Hospital /ID# 242970
-
Hiroshima, Hiroshima, 일본, 734-8551
- 모병
- Hiroshima University Hospital /ID# 241882
-
-
Hokkaido
-
Sapporo, Hokkaido, 일본, 060-8648
- 모병
- Hokkaido University Hospital /ID# 241289
-
-
Hyōgo
-
Kobe, Hyōgo, 일본, 650-0046
- 모병
- Kobe Minimally Invasive Cancer Center /ID# 254131
-
Takarazuka-shi, Hyōgo, 일본, 665-0827
- 모병
- Takarazuka City Hospital /ID# 240786
-
-
Ibaraki
-
Higashiibaraki-gun, Ibaraki, 일본, 311-3193
- 모병
- NHO Mito Medical Center /ID# 241709
-
Kasama-shi, Ibaraki, 일본, 309-1793
- 모병
- Ibaraki Prefectural Central Hospital /ID# 246145
-
-
Iwate
-
Shiwa-gun, Iwate, 일본, 028-3695
- 모병
- Iwate Medical University Hospital /ID# 239027
-
-
Kanagawa
-
Sagamihara-shi, Kanagawa, 일본, 252-0375
- 모병
- Kitasato University Hospital /ID# 239958
-
Yokohama, Kanagawa, 일본, 232-0024
- 모병
- Yokohama City University Medical Center /ID# 246554
-
Yokohama, Kanagawa, 일본, 236-0051
- 모병
- Kanagawa Cardiovascular and Respiratory Center /ID# 239052
-
-
Kumamoto
-
Kumamoto, Kumamoto, 일본, 8608556
- 모병
- Kumamoto University Hospital /ID# 241039
-
-
Mie-ken
-
Tsu, Mie-ken, 일본, 514-1101
- 모병
- National Hospital Organization Mie Chuo Medical Center /ID# 246659
-
-
Miyagi
-
Natori-shi, Miyagi, 일본, 981-1293
- 모병
- Miyagi Cancer Center /ID# 234198
-
Sendai, Miyagi, 일본, 980-0873
- 모병
- Sendai Kousei Hospital /ID# 253350
-
-
Miyazaki
-
Miyazaki, Miyazaki, 일본, 889-1692
- 모병
- University of Miyazaki Hospital /ID# 242161
-
-
Niigata
-
Nagaoka-shi, Niigata, 일본, 940-2085
- 모병
- Nagaoka Red Cross Hospital /ID# 240714
-
-
Okayama-ken
-
Kurashiki-shi, Okayama-ken, 일본, 710-8602
- 모병
- Kurashiki Central Hospital /ID# 239344
-
-
Osaka
-
Habikino-shi, Osaka, 일본, 583-8588
- 모병
- Osaka Habikino Medical Center /ID# 239989
-
Hirakata-shi, Osaka, 일본, 573-1191
- 모병
- Kansai Medical University Hospital /ID# 233476
-
Osaka, Osaka, 일본, 545-8586
- 모병
- Osaka Metropolitan University Hospital /ID# 238895
-
Sakai-shi, Osaka, 일본, 590-0197
- 모병
- Kindai University Hospital /ID# 239085
-
-
Shizuoka
-
Fujieda-shi, Shizuoka, 일본, 426-8677
- 모병
- Fujieda Municipal General Hospital /ID# 255155
-
-
Tochigi
-
Utsunomiya, Tochigi, 일본, 320-0834
- 모병
- Tochigi Cancer Center /ID# 240020
-
-
Tokyo
-
Bunkyo-ku, Tokyo, 일본, 113-8431
- 모병
- Juntendo University Hospital /ID# 239932
-
Chuo-ku, Tokyo, 일본, 104-0045
- 모병
- National Cancer Center Hospital /ID# 251134
-
Meguro-ku, Tokyo, 일본, 152-8902
- 모병
- National Hospital Organization Tokyo Medical Center /ID# 246581
-
연락하다:
- Site Coordinator
- 전화번호: +81-3-3411-0111
-
Shinagawa-ku, Tokyo, 일본, 141-8625
- 모병
- NTT Medical Center Tokyo /ID# 241067
-
Shinjuku-ku, Tokyo, 일본, 160-8582
- 모병
- Keio University Hospital /ID# 239506
-
-
Toyama
-
Toyama, Toyama, 일본, 930-0194
- 모병
- Toyama University Hospital /ID# 241660
-
-
Wakayama
-
Wakayama, Wakayama, 일본, 641-8510
- 모병
- Wakayama Medical University Hospital /ID# 234004
-
-
Yamagata
-
Yamagata, Yamagata, 일본, 990-9585
- 완전한
- Yamagata University Hospital /ID# 240815
-
-
Yamaguchi
-
Ube-shi, Yamaguchi, 일본, 755-0241
- 모병
- Yamaguchi - Ube Medical Center /ID# 258779
-
-
-
-
Anhui
-
Hefei, Anhui, 중국, 230032
- 모병
- Anhui Medical University - Anhui Chest Hospital /ID# 231899
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, 중국, 100142
- 모병
- Beijing Cancer Hospital /ID# 231923
-
Beijing, Beijing Municipality, 중국, 101149
- 모병
- Beijing Chest Hospital, Capital Medical University /ID# 232202
-
Beijing, Beijing Municipality, 중국, 100730
- 모병
- Peking Union Medical College Hospital East - Dongdan Campus /ID# 233175
-
-
Chongqing Municipality
-
Chongqing, Chongqing Municipality, 중국, 400016
- 모병
- The First Affiliated Hospital of Chongqing Medical University /ID# 251592
-
-
Fujian
-
Fuzhou, Fujian, 중국, 350014
- 모병
- Fujian Provincial Cancer Hospital /ID# 243134
-
Xiamen, Fujian, 중국, 361003
- 모병
- The First Affiliated Hospital of Xiamen University /ID# 242381
-
-
Guangdong
-
Guangzhou, Guangdong, 중국, 510120
- 모병
- The First Affiliated Hospital Of Guangzhou Medical University - Yanjiang W Road /ID# 238591
-
Shantou, Guangdong, 중국, 515041
- 모병
- Cancer Hospital of Shantou University Medical College /ID# 242182
-
Zhanjiang, Guangdong, 중국, 524004
- 모병
- Affiliated Hospital of Guangdong Medical College /ID# 233317
-
-
Guangxi
-
Nanning, Guangxi, 중국, 530021
- 모병
- Affiliated Cancer Hospital of Guangxi Medical University /ID# 231855
-
-
Guizhou
-
Guiyang, Guizhou, 중국, 550002
- 모병
- People's Hospital of Guizhou Province /ID# 243614
-
-
Hebei
-
Baoding, Hebei, 중국, 071000
- 모병
- Affiliated Hospital of Hebei University /ID# 239586
-
-
Heilongjiang
-
Harbin, Heilongjiang, 중국, 150081
- 모병
- Harbin Medical University Cancer Hospital /Id# 231941
-
-
Henan
-
Nanyang, Henan, 중국, 473007
- 모병
- The First affiliated Hospital of Nanyang Medical College /ID# 244652
-
Zhengzhou, Henan, 중국, 450008
- 모병
- Henan Cancer Hospital /ID# 239577
-
Zhengzhou, Henan, 중국, 450003
- 모병
- People's Hospital of Henan Province /ID# 242187
-
-
Hubei
-
Wuhan, Hubei, 중국, 430030
- 모병
- Tongji Hospital Tongji Medical College of HUST /ID# 239575
-
Wuhan, Hubei, 중국, 430079
- 모병
- Hubei Cancer Hospital /ID# 240045
-
Wuhan, Hubei, 중국, 430048
- 모병
- Union Hospital Tongji Medical College /ID# 231904
-
-
Hunan
-
Changsha, Hunan, 중국, 410006
- 모병
- Hunan Cancer Hospital /ID# 231943
-
-
Inner Mongolia
-
Hohhot, Inner Mongolia, 중국, 010050
- 완전한
- The Affiliated Hospital of Inner Mongolia Medical University /ID# 242179
-
-
Jiangsu
-
Nanjing, Jiangsu, 중국, 210008
- 모병
- Nanjing Drum Tower Hospital /ID# 231791
-
Nantong, Jiangsu, 중국, 226300
- 모병
- Nantong Tumor Hospital /ID# 232424
-
-
Jiangxi
-
Nanchang, Jiangxi, 중국, 330008
- 모병
- The Second Affiliated Hospital of Nanchang University /ID# 231935
-
Nanchang, Jiangxi, 중국, 330209
- 모병
- The First Affiliated Hospital of Nanchang University - Xianghu Campus /ID# 231934
-
-
Jilin
-
Changchun, Jilin, 중국, 130012
- 모병
- Jilin Cancer Hospital /ID# 244702
-
-
Liaoning
-
Dalian, Liaoning, 중국, 116023
- 모병
- The Second Affiliated Hospital of Dalian Medical University /ID# 239755
-
Shenyang, Liaoning, 중국, 110001
- 모병
- First Affiliated Hospital of China Medical University /ID# 231924
-
-
Shaanxi
-
Xi'an, Shaanxi, 중국, 710061
- 모병
- The First Affiliated Hospital of Xi'an Jiaotong University /ID# 232023
-
-
Shandong
-
Jinan, Shandong, 중국, 250013
- 모병
- Jinan Central Hospital /ID# 231895
-
Jinan, Shandong, 중국, 251601
- 모병
- Shandong Cancer Hospital /ID# 251506
-
Linyi, Shandong, 중국, 276001
- 모병
- LinYi Cancer Hospital /ID# 239713
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, 중국, 200030
- 모병
- Shanghai Chest Hospital /ID# 231897
-
-
Shanxi
-
Taiyuan, Shanxi, 중국, 030009
- 모병
- Shanxi Cancer Hospital /ID# 258674
-
-
Sichuan
-
Chengdu, Sichuan, 중국, 610041
- 모병
- Sichuan Cancer Hospital /ID# 239707
-
Chengdu, Sichuan, 중국, 610041
- 모병
- West China Hospital, Sichuan University /ID# 233703
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, 중국, 300000
- 모병
- Tianjin Cancer Hospital /ID# 233176
-
Tianjin, Tianjin Municipality, 중국, 300052
- 모병
- Tianjin Medical University General Hospital /ID# 231839
-
-
Xinjiang
-
Ürümqi, Xinjiang, 중국, 830000
- 모병
- The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 240094
-
-
Yunnan
-
Kunming, Yunnan, 중국, 650118
- 모병
- Yunnan Cancer Hospital /ID# 251388
-
-
Zhejiang
-
Hangzhou, Zhejiang, 중국, 310022
- 모병
- Zhejiang Cancer hospital /ID# 242476
-
Hangzhou, Zhejiang, 중국, 310003
- 모병
- The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 232032
-
Linhai, Zhejiang, 중국, 317000
- 모병
- Taizhou Hospital of Zhejiang Province /ID# 232021
-
Ningbo, Zhejiang, 중국, 315010
- 모병
- Ningbo No. 2 Hospital /ID# 242478
-
-
-
-
-
Brno, 체코, 656 53
- 모병
- Masarykuv onkologicky ustav /ID# 232426
-
Nový Jičín, 체코, 741 01
- 완전한
- Nemocnice AGEL Novy Jicin, a.s. /ID# 232427
-
-
-
-
-
Santiago, 칠레, 7501504
- 모병
- Hospital Clinico Universidad De Los Andes /ID# 260974
-
-
Maule Region
-
Talca, Maule Region, 칠레, 3461341
- 모병
- Clinica Universidad Catolica del Maule /ID# 231294
-
-
Santiago Metropolitan
-
La Florida, Santiago Metropolitan, 칠레, 8241479
- 모병
- Icegclinic /Id# 231212
-
Providencia, Santiago Metropolitan, 칠레, 7500713
- 모병
- Sociedad Prosalud Montes y Orlandi /ID# 231154
-
Providencia, Santiago Metropolitan, 칠레, 7500921
- 모병
- Fundacion Arturo Lopez Perez /ID# 231151
-
Providencia, Santiago Metropolitan, 칠레, 7510032
- 완전한
- Sociedad Oncovida /ID# 231152
-
-
-
-
Alberta
-
Edmonton, Alberta, 캐나다, T6G 1Z2
- 모병
- Cross Cancer Institute. /ID# 252065
-
-
Ontario
-
Brampton, Ontario, 캐나다, L6R 3J7
- 모병
- William Osler Health System - Brampton Civic Hospital /ID# 254420
-
-
Quebec
-
Greenfield Park, Quebec, 캐나다, J4V 2H1
- 모병
- CISSS de la Monteregie /ID# 239081
-
Lévis, Quebec, 캐나다, G6V 3Z1
- 모병
- CSSS Alphonse-Desjardins, CHAU de Levis /ID# 261158
-
Montreal, Quebec, 캐나다, H4J 1C5
- 모병
- Hopital Du Sacre-Coeur De Montreal /ID# 274584
-
-
-
-
Antioquia
-
Medellín, Antioquia, 콜롬비아, 050034
- 모병
- Hospital Pablo Tobon Uribe /ID# 258128
-
-
Bogota D.C.
-
Bogotá, Bogota D.C., 콜롬비아, 110131
- 모병
- Fundacion Ctic - Centro De Tratamiento E Investigacion Sobre Cancer Luis Carlos /ID# 258131
-
-
Cesar Department
-
Valledupar, Cesar Department, 콜롬비아, 200001
- 모병
- Sociedad de Oncologia y Hematologia del Cesar SAS /ID# 258130
-
-
Departamento de Córdoba
-
Montería, Departamento de Córdoba, 콜롬비아, 230018
- 모병
- Imat Oncomedica /ID# 258129
-
-
-
-
-
Adana, 터키 (Türkiye), 01060
- 모병
- Adana Sehir Egitim ve Arastirma Hastanesi /ID# 255638
-
Adana, 터키 (Türkiye), 01130
- 완전한
- Adana Acıbadem Hospital /ID# 234208
-
Adana, 터키 (Türkiye), 01140
- 모병
- Medical Park Seyhan Hastanesi /ID# 255637
-
Ankara, 터키 (Türkiye), 06560
- 모병
- Gazi Universitesi /ID# 265425
-
Ankara, 터키 (Türkiye), 06800
- 모병
- Ankara City hospital /ID# 234210
-
Battalgazi/malatya, 터키 (Türkiye), 44280
- 모병
- Inonu Universitesi Turgut Ozal /ID# 234038
-
Bursa, 터키 (Türkiye), 16059
- 모병
- Uludag University Medical Faculty /ID# 234205
-
Diyarbakır, 터키 (Türkiye), 21200
- 모병
- Dicle Universitesi Tip /ID# 234036
-
Istanbul, 터키 (Türkiye), 34214
- 모병
- Bagcilar Medipol Mega Universite Hastanesi /ID# 234211
-
Izmir, 터키 (Türkiye), 35040
- 모병
- Ege University Medical Faculty /ID# 234039
-
Izmir, 터키 (Türkiye), 35110
- 모병
- Dr. Suat Seren Gogus Has /ID# 262291
-
-
Ankara
-
Çankaya, Ankara, 터키 (Türkiye), 06520
- 모병
- Memorial Ankara Hastanesi /ID# 234212
-
-
İzmir
-
Cordaleo, İzmir, 터키 (Türkiye), 35575
- 모병
- Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 234209
-
-
-
-
-
Porto, 포르투갈, 4100-180
- 모병
- Hospital CUF Porto /ID# 241570
-
Porto, 포르투갈, 4099-001
- 모병
- Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 241572
-
Porto, 포르투갈, 4200-072
- 모병
- IPO Porto FG, EPE /ID# 241569
-
Porto, 포르투갈, 4200-319
- 모병
- Unidade Local de Saude Sao Joao /ID# 241930
-
-
Lisbon District
-
Lisbon, Lisbon District, 포르투갈, 1400-038
- 모병
- Fundacao Champalimaud /ID# 241925
-
-
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, 폴란드, 60-569
- 모병
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla /ID# 262489
-
-
Masovian Voivodeship
-
Warsaw, Masovian Voivodeship, 폴란드, 02-781
- 모병
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 262095
-
-
Podkarpackie Voivodeship
-
Rzeszów, Podkarpackie Voivodeship, 폴란드, 35-021
- 모병
- MRUK-MED I Sp. z o.o. /ID# 239363
-
-
Warmian-Masurian Voivodeship
-
Olsztyn, Warmian-Masurian Voivodeship, 폴란드, 10-357
- 모병
- Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie /ID# 239025
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, 폴란드, 93-338
- 모병
- Instytut Centrum Zdrowia Matki Polki /ID# 239024
-
-
-
-
-
Paris, 프랑스, 75020
- 모병
- AP-HP - Hopital Tenon /ID# 239179
-
-
Bouches-du-Rhone
-
Marseille, Bouches-du-Rhone, 프랑스, 13015
- 모병
- APHM - Hopital Nord /ID# 251935
-
-
Hauts-de-France
-
Lille, Hauts-de-France, 프랑스, 59037
- 모병
- Centre Hospitalier Regional Universitaire de Lille - Hopital Albert Calmette /ID# 251934
-
-
Herault
-
Montpellier, Herault, 프랑스, 34295
- 모병
- Hopital Arnaud de Villeneuve /ID# 239404
-
-
New Aquitaine
-
Pessac, New Aquitaine, 프랑스, 33604
- 모병
- Centre Hospitalier Universitaire de Bordeaux /ID# 244953
-
-
Paris
-
Paris, Paris, 프랑스, 75248
- 모병
- Institut Curie /ID# 240141
-
Paris, Paris, 프랑스, 75679
- 모병
- Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 239409
-
-
Provence-Alpes-Côte d'Azur Region
-
Avignon, Provence-Alpes-Côte d'Azur Region, 프랑스, 84000
- 모병
- Centre Hospitalier d'Avignon /ID# 275229
-
-
Rhone
-
Bron, Rhone, 프랑스, 69500
- 모병
- Hospices Civils de Lyon - Hopital Louis Pradel /ID# 251933
-
Lyon, Rhone, 프랑스, 69373
- 모병
- Centre Leon Berard /ID# 267397
-
-
Val-de-Marne
-
Créteil, Val-de-Marne, 프랑스, 94000
- 모병
- Centre Hosp Intercommunal de Creteil /ID# 251936
-
-
Île-de-France Region
-
Villejuif, Île-de-France Region, 프랑스, 94800
- 모병
- Institut Gustave Roussy /ID# 267415
-
-
-
-
New South Wales
-
Port Macquarie, New South Wales, 호주, 2444
- 모병
- Port Macquarie Base Hospital /ID# 273654
-
Westmead, New South Wales, 호주, 2145
- 모병
- Westmead Hospital /ID# 274447
-
-
Victoria
-
Geelong, Victoria, 호주, 3220
- 모병
- Barwon Health /ID# 241920
-
Heidelberg, Victoria, 호주, 3084
- 모병
- Austin Health /ID# 247507
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 이상 (성인, 고령자)
건강한 자원 봉사자를 받아들입니다
아니
연구 대상 성별
모두
설명
Inclusion Criteria:
-
Projected life expectancy of at least 12 weeks.
-
Participants must have c-Met overexpressing non-small cell lung cancer (NSCLC) as assessed by an AbbVie designated immunohistochemistry (IHC) laboratory using the VENTANA MET (SP44) RxDx assay.
-
Archival or fresh tumor material must be submitted for assessment of c-Met protein expression levels during the Pre-Screening period. Tumor material from the primary tumor site and/or metastatic sites are allowed.
- If a participant was prescreened for Study M14-239 but did not enroll, tumor material previously submitted for Study M14-239 may be used for Study M18-868 Pre-Screening upon confirmation from AbbVie that sufficient evaluable tumor material is available (Except China).
-
A histologically or cytologically documented non-squamous cell NSCLC that is locally advanced or metastatic.
-
A known epidermal growth factor receptor (EGFR) activating mutation status.
-- Participants with EGFR activating mutations are not eligible
-
Actionable alterations in genes other than EGFR are eligible.
-
Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
-
An Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1.
-
Have received no more than 1 line of prior systemic cytotoxic chemotherapy in the locally advanced or metastatic setting.
-
Have progressed on at least 1 line of prior therapy for locally advanced/metastatic NSCLC
-
Participants WITHOUT an actionable gene alteration: must have progressed on (or be considered ineligible for) platinum-based chemotherapy and immune checkpoint inhibitor (as monotherapy or in combination with chemotherapy).
-
Participants WITH an actionable gene alteration for which immune checkpoint inhibitor therapy is not standard of care (e.g., anaplastic lymphoma kinase [ALK] translocation): must have progressed on (or be considered ineligible for) anti-cancer therapy targeting driver gene alterations and platinum-based chemotherapy.
- Participants with gene alterations for which immune checkpoint inhibitor is standard of care must have also progressed on (or be considered ineligible for) immune checkpoint inhibitor (as monotherapy or in combination with chemotherapy).
-
-
Must be considered appropriate for docetaxel therapy based on the assessment of the treating physician.
-
Participants with metastases to the central nervous system (CNS) are eligible only after adequate treatment (such as surgery, radiotherapy, or drug therapy) is provided and:
- They are asymptomatic and off or on a stable or reducing dose of systemic steroids (on no more than 10 mg per day [QD] prednisone or equivalent) and/or anticonvulsants for at least 2 weeks prior to randomization.
Exclusion Criteria:
-
Evidence of new, untreated CNS metastases or progressing CNS metastases after treatment.
-
Evidence of leptomeningeal disease.
-
Participants with adenosquamous or neuroendocrine histology, nor sarcomatoid features.
-
Epidermal growth factor receptor (EGFR) activating mutations.
-
Participants who have received prior c-Met-targeted antibodies, prior telisotuzumab vedotin, or prior antibody-drug conjugates either targeting c-Met or consisting of monomethylauristatin E..
-
Participants who have received prior docetaxel therapy.
-
A history of other malignancies except:
- Malignancy treated with curative intent and with no known active disease present for >=2 years before the first dose of study drug and felt to be at low risk for recurrence by investigator. Additionally, participants must not be receiving any ongoing anti-cancer therapy, including maintenance therapy, prior to randomization..
- Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease.
- Adequately treated carcinoma in situ without current evidence of disease.
-
A history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, evidence of active pneumonitis on screening chest computed tomography (CT) scan or prior pneumonectomy. A history of prior radiation pneumonitis in the radiation field (fibrosis) is not permitted.
-
Unresolved nor adverse event (AE) >= Grade 2 from prior anticancer therapy, except for alopecia or anemia. Participants with hormone deficiencies caused by prior anticancer therapy who are asymptomatic and on a stable dose of replacement hormone are eligible for study.
-
Major surgery within 21 days prior to randomization.
-
Clinically significant condition(s) as listed in the protocol.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: Telisotuzumab Vedotin
Participants will receive telisotuzumab vedotin every 2 weeks until meeting study drug discontinuation criteria. |
Intravenous (IV) Infusion
다른 이름들:
|
|
활성 비교기: Docetaxel
Participants will receive docetaxel every 3 weeks until meeting study drug discontinuation criteria. |
IV Infusion |
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Progression-Free Survival (PFS) per Blinded Independent Central Review (BICR)
기간: Up to approximately 39 months
|
PFS is defined as the time from randomization to the first occurrence of radiographic progression based on Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 (v1.1) per BICR or death from any cause. |
Up to approximately 39 months
|
|
Overall Survival (OS)
기간: Up to approximately 39 months
|
OS is defined as the time from randomization to the event of death from any cause. |
Up to approximately 39 months
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Objective Response Rate (ORR), per BICR.
기간: Up to approximately 58.25 months
|
ORR is defined as the proportion of participants with a complete response (CR) or partial response (PR) based on RECIST v1.1 |
Up to approximately 58.25 months
|
|
Duration of Response (DoR), per BICR
기간: Up to approximately 58.25 months
|
DoR is defined for responders as the time from response (CR or PR) to the first occurrence of radiographic progression per RECIST v1.1 or death from any cause. |
Up to approximately 58.25 months
|
|
PFS per Investigator Assessment
기간: Up to approximately 58.25 months
|
PFS is defined as the time from randomization to the first occurrence of radiographic progression based on RECIST version 1.1 per investigator or death from any cause. Participants with no PFS event will be censored at the last evaluable radiographic assessment per investigator. Participants with no event and no evaluable post-baseline assessment will be censored at randomization. |
Up to approximately 58.25 months
|
|
Change from Baseline of Physical Functioning as measured by the Physical Functioning domain of the EORTC-QLQ-Core 30 (EORTC QLQ-C30).
기간: Up to approximately 12 Weeks
|
The EORTC QLQ-C30 assesses health-related quality of life in cancer patients participating in clinical trials. The EORTC QLQ-C30 comprises 5 functional scales (physical, role, emotional, social, cognitive), 8 single-item symptom scales (fatigue, pain, nausea/vomiting, appetite loss, constipation, diarrhea, insomnia, and dyspnea), as well as subscales assessing global health/quality of life and financial impact. Raw scores are transformed to a scale of 0 to 100, with higher scores representing better functioning/quality of life and greater symptom burden. |
Up to approximately 12 Weeks
|
|
Change from Baseline in Quality of Life as measured by the Global Health Status/Quality of Life Domain of the EORTC QLQ-C30.
기간: Up to approximately 12 Weeks
|
The EORTC QLQ-C30 assesses health-related quality of life in cancer patients participating in clinical trials. The EORTC QLQ-C30 comprises 5 functional scales (physical, role, emotional, social, cognitive), 8 single-item symptom scales (fatigue, pain, nausea/vomiting, appetite loss, constipation, diarrhea, insomnia, and dyspnea), as well as subscales assessing global health/quality of life and financial impact. Raw scores are transformed to a scale of 0 to 100, with higher scores representing better functioning/quality of life and greater symptom burden. |
Up to approximately 12 Weeks
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
스폰서
수사관
- 연구 책임자: ABBVIE INC., AbbVie
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
2022년 3월 25일
기본 완료 (추정된)
2028년 12월 1일
연구 완료 (추정된)
2029년 2월 1일
연구 등록 날짜
최초 제출
2021년 6월 14일
QC 기준을 충족하는 최초 제출
2021년 6월 14일
처음 게시됨 (실제)
2021년 6월 16일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 10월 29일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 10월 27일
마지막으로 확인됨
2026년 10월 1일
추가 정보
이 연구와 관련된 용어
키워드
추가 관련 MeSH 약관
기타 연구 ID 번호
- M18-868
- 2023-505749-14-00 (기타 식별자: EU CT)
- 2023 (미국 NIH 보조금/계약)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
예
IPD 계획 설명
AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.
IPD 공유 기간
For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/
IPD 공유 액세스 기준
To learn more about the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
IPD 공유 지원 정보 유형
- 연구_프로토콜
- 수액
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
예
미국 FDA 규제 기기 제품 연구
아니
미국에서 제조되어 미국에서 수출되는 제품
예
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .