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단일 요법으로서 Sacituzumab tirumotecan (SAC-TMT, MK-2870)에 대한 연구 및 삼중 음성 유방암을 가진 참가자 (MK-2870-011/TROFUSE-011)에서 펨브 롤리 주맙 (MK-3475)과의 연구.

2026년 10월 11일 업데이트: Merck Sharp & Dohme LLC

단일 요법으로서 Sacituzumab tirumotecan (SAC-TMT, MK-2870)의 효능 및 안전성을 비교하는 3 상, 무작위 개방형 연구 및 펨브 롤리 주맙 (MK-3475)과 결합하여, 국소 적으로 전도되지 않은 참가자와의 의사의 선택에 비해. CPS에서 PD-L1을 발현하는 재발 성되지 않은 또는 전이성 삼중 음성 유방암 10 미만 (Trofuse-011)

Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.

연구 개요

상태

모병

정황

개입 / 치료

연구 유형

중재적

등록 (추정된)

1000

단계

  • 3단계

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

연구 장소

  • 그리스
      • Thessaloniki, 그리스, 570 01
        • 모병
        • European Interbalkan Medical Center ( Site 3901)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0030 2313252011
    • Attica
      • Athens, Attica, 그리스, 115 28
        • 모병
        • Aretaieio Hospital ( Site 3900)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0030 2107286444
    • Irakleio
      • Heraklion, Irakleio, 그리스, 715 00
        • 모병
        • University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 3903)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0030 2810392091
    • Thessaly
      • Larissa, Thessaly, 그리스, 411 10
        • 모병
        • General University Hospital of Larissa, Oncology Clinic ( Site 3902)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0030 2413501636
  • 네덜란드
      • Groningen, 네덜란드, 9728 NT
        • 모병
        • Martini Ziekenhuis ( Site 4502)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31505246311
    • Gelderland
      • Arnhem, Gelderland, 네덜란드, 6815 AD
        • 모병
        • Ziekenhuis Rijnstate ( Site 4501)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31880056201
    • Limburg
      • Sittard Geleen, Limburg, 네덜란드, 6162BP
        • 모병
        • Zuyderland Medical Centre ( Site 4507)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31884590400
    • North Brabant
      • Tilburg, North Brabant, 네덜란드, 5022 GC
        • 모병
        • ETZ Elisabeth ( Site 4504)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31132210425
    • Overijssel
      • Deventer, Overijssel, 네덜란드, 7416 SE
        • 모병
        • Deventer Ziekenhuis ( Site 4503)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31570596437
    • South Holland
      • Rotterdam, South Holland, 네덜란드, 3015 GD
        • 모병
        • Erasmus Medisch Centrum ( Site 4505)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31107041733
    • Utrecht
      • Amersfoort, Utrecht, 네덜란드, 3813 TZ
        • 모병
        • Meander Medisch Centrum ( Site 4500)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +31338507278
  • 뉴질랜드
    • Auckland
      • Newmarket, Auckland, 뉴질랜드, 1023
        • 모병
        • Harbour Cancer & Wellness ( Site 5600)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +64 9 220 3333
    • Wellington Region
      • Crofton Downs, Wellington Region, 뉴질랜드, 6035
        • 모병
        • Bowen Icon Cancer Centre ( Site 5601)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +64 9 479 2069
  • 대만
      • Taichung, 대만, 407
        • 모병
        • Taichung Veterans General Hospital ( Site 5303)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +886-4-2359-2525
      • Tainan, 대만, 70403
        • 모병
        • National Cheng Kung University Hospital ( Site 5304)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +886-6-235-3535
      • Taipei, 대만, 104
        • 모병
        • Mackay Memorial Hospital ( Site 5301)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +886-2-25433535
      • Taipei, 대만, 100225
        • 모병
        • National Taiwan University Hospital ( Site 5300)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +886-2-23123456
      • Taoyuan, 대만, 333
        • 모병
        • Chang Gung Memorial Hospital ( Site 5302)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +886-3-328-1200
  • 대한민국
      • Seoul, 대한민국, 03080
        • 모병
        • Seoul National University Hospital ( Site 5200)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +82220720850
      • Seoul, 대한민국, 03722
        • 모병
        • Severance Hospital Yonsei University Health System ( Site 5201)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +82222288135
      • Seoul, 대한민국, 06351
        • 모병
        • Samsung Medical Center ( Site 5203)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 82234106488
    • Kyonggi-do
      • Goyang-si, Kyonggi-do, 대한민국, 10408
        • 모병
        • National Cancer Center ( Site 5202)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +82319201623
      • Seongnam, Kyonggi-do, 대한민국, 13620
        • 모병
        • Seoul National University Bundang Hospital ( Site 5204)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 82317877022
    • Taegu-Kwangyokshi
      • Daegu, Taegu-Kwangyokshi, 대한민국, 41404
        • 모병
        • Kyungpook National University Chilgok Hospital ( Site 5205)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 82532002625
  • 덴마크
    • Capital Region
      • Copenhagen, Capital Region, 덴마크, 2730
        • 모병
        • Herlev og Gentofte Hospital. ( Site 3205)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4538683868
      • Copenhagen, Capital Region, 덴마크, 2100
        • 모병
        • Rigshospitalet University Hospital ( Site 3201)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4535453545
    • Central Jutland
      • Aarhus, Central Jutland, 덴마크, 8200
        • 모병
        • Aarhus Universitets hospital ( Site 3204)
        • 연락하다:
          • Study Coordinator
          • 전화번호: + 4578450000
    • Region Syddanmark
      • Odense, Region Syddanmark, 덴마크, 5000
        • 모병
        • Odense Universitetshospital ( Site 3202)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4566113333
  • 독일
      • Berlin, 독일, 13125
        • 모병
        • HELIOS Klinikum Berlin-Buch ( Site 4303)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4930940153300
    • Bavaria
      • Erlangen, Bavaria, 독일, 91054
        • 모병
        • Universitatsklinikum Erlangen ( Site 4302)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4991318544082
    • North Rhine-Westphalia
      • Düsseldorf, North Rhine-Westphalia, 독일, 40235
        • 완전한
        • Luisenkrankenhaus Düsseldorf ( Site 4305)
      • Essen, North Rhine-Westphalia, 독일, 45136
        • 모병
        • Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Senologie/ Brustzentrum ( Site 4304)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4920117433001
    • Saarland
      • Saarbrücken, Saarland, 독일, 66113
        • 모병
        • Caritas Klinikum Saarbruecken St. Theresia ( Site 4301)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +496814061345
    • Saxony
      • Leipzig, Saxony, 독일, 04103
        • 모병
        • Universitaetsklinikum Leipzig ( Site 4307)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +4934197109
  • 루마니아
      • Bucharest, 루마니아, 077190
        • 모병
        • Centrul Medical Neolife- Baneasa ( Site 4706)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40219230
      • Bucharest, 루마니아, 011171
        • 모병
        • Spitalul Clinic Filantropia ( Site 4703)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40213188930
    • Cluj
      • Cluj-Napoca, Cluj, 루마니아, 400015
        • 모병
        • Institutul Oncologic Cluj ( Site 4701)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40264598362
      • Comuna Floresti, Cluj, 루마니아, 407280
        • 모병
        • S.C. Radiotherapy Center Cluj S.R.L ( Site 4705)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40219368
    • Dolj
      • Craiova, Dolj, 루마니아, 200542
        • 모병
        • Centrul de Oncologie "Sfântul Nectarie" ( Site 4702)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40731604432
    • Prahova
      • Ploieşti, Prahova, 루마니아, 100337
        • 모병
        • Spitalul Municipal Schuller Ploiești ( Site 4707)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40723943507
    • Timiș County
      • Timișoara, Timiș County, 루마니아, 300239
        • 모병
        • Cabinet Medical Oncomed ( Site 4704)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +40356460995
  • 말레이시아
      • Kuala Lumpur, 말레이시아, 59100
        • 모병
        • University Malaya Medical Centre ( Site 5403)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +60479492351
      • Kuala Lumpur, 말레이시아, 59100
        • 모병
        • Pantai Hospital Kuala Lumpur ( Site 5402)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +60322960888
    • Putrajaya
      • Putrajaya, Putrajaya, 말레이시아, 62250
        • 모병
        • National Cancer Institute ( Site 5401)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +60388925418
    • Sarawak
      • Kuching, Sarawak, 말레이시아, 93586
        • 모병
        • Sarawak General Hospital ( Site 5400)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +6082276820
  • 멕시코
      • Aguascalientes, 멕시코, 20124
        • 모병
        • Centro de Investigación Oncológica Galerías SC ( Site 2511)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +524496890593
      • Chihuahua City, 멕시코, 31123
        • 모병
        • Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 2510)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 526144253458712
      • San Luis Potosí City, 멕시코, 78250
        • 모병
        • Centro Potosino de Investigación Médica ( Site 2512)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 52 444 475 2715
    • Jalisco
      • Guadalajara, Jalisco, 멕시코, 44630
        • 모병
        • CIO - Centro de Inmuno-Oncología de Occidente ( Site 2504)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 3330447001
    • Mexico City
      • Benito Juárez, Mexico City, 멕시코, 03100
        • 모병
        • Grupo Médico ASSET SC ( Site 2507)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 2223813254
      • Mexico City, Mexico City, 멕시코, 06140
        • 모병
        • Centro Oncologico de Alta Especialidad, S.C. ( Site 2509)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +52 55 5286 5738
      • Mexico City, Mexico City, 멕시코, 11810
        • 모병
        • Higiea Oncologia ( Site 2505)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +525554137773
      • Mexico City, Mexico City, 멕시코, 04700
        • 모병
        • COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 2514)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +525554248970
    • Nuevo León
      • Monterrey, Nuevo León, 멕시코, 64460
        • 모병
        • Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 2501)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +528125761529
      • Monterrey, Nuevo León, 멕시코, 64460
        • 모병
        • Filios Alta Medicina ( Site 2506)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +528131813571
      • San Pedro Garza García, Nuevo León, 멕시코, 66220
        • 모병
        • Oncare - Unidad Valle ( Site 2502)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +528115337180
    • Oaxaca
      • Oaxaca City, Oaxaca, 멕시코, 68020
        • 모병
        • Centro de Investigacion Clinica de Oaxaca ( Site 2503)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +529516035559
  • 미국
    • Alabama
      • Mobile, Alabama, 미국, 36604
        • 모병
        • USA Mitchell Cancer Institute ( Site 0090)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 251-410-4924
    • Arizona
      • Chandler, Arizona, 미국, 85224
        • 모병
        • Ironwood Cancer & Research Centers ( Site 0036)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 623-312-3000
    • California
      • Duarte, California, 미국, 91010
        • 모병
        • City of Hope ( Site 0097)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 626-218-9845
      • Irvine, California, 미국, 92618
        • 모병
        • City of Hope Lennar Foundation Cancer Center ( Site 0099)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 626-218-0720
      • Los Angeles, California, 미국, 90095
        • 모병
        • UCLA Department of Medicine - Hematology & Oncology ( Site 0047)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 650-283-5067
      • San Francisco, California, 미국, 94158
        • 모병
        • UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0016)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 415-353-7070
    • Connecticut
      • New Haven, Connecticut, 미국, 06520
        • 완전한
        • Yale New Haven Hospital ( Site 0001)
    • District of Columbia
      • Washington D.C., District of Columbia, 미국, 20010-2975
        • 모병
        • Washington Hospital Center ( Site 0098)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 202-877-8839
    • Florida
      • Altamonte Springs, Florida, 미국, 32701
        • 모병
        • AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 407-303-2284
      • Orlando, Florida, 미국, 32806
        • 모병
        • Orlando Health Cancer Institute ( Site 0012)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 321-841-8284
      • West Palm Beach, Florida, 미국, 33401
        • 모병
        • Florida Cancer Specialists - East ( Site 7000)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 561-366-4100
    • Georgia
      • Athens, Georgia, 미국, 30607
        • 모병
        • University Cancer & Blood Center, LLC ( Site 0023)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 706-353-2990
    • Idaho
      • Boise, Idaho, 미국, 83712
        • 모병
        • St. Luke's Cancer Institute: Boise ( Site 0037)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 208-381-2711
    • Illinois
      • Chicago, Illinois, 미국, 60612
        • 모병
        • University of Illinois Cancer Center ( Site 0044)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 312-996-1581
    • Maryland
      • Baltimore, Maryland, 미국, 21237
        • 모병
        • MedStar Franklin Square Medical Center ( Site 0031)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 443-777-7147
      • Baltimore, Maryland, 미국, 21239
        • 모병
        • MedStar Good Samaritan Hospital ( Site 0079)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 443-777-7147
      • Clinton, Maryland, 미국, 20735
        • 모병
        • MedStar Southern Maryland Hospital Center ( Site 0100)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 301-877-4673
      • Olney, Maryland, 미국, 20832
        • 모병
        • MedStar Montgomery Medical Center ( Site 0078)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 301-774-8882
      • Silver Spring, Maryland, 미국, 20910
        • 모병
        • Holy Cross Hospital ( Site 0091)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 301-754-7552
    • Michigan
      • Grand Rapids, Michigan, 미국, 49503
        • 모병
        • Cancer & Hematology Centers of Western Michigan ( Site 0026)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 616-954-9800
    • Minnesota
      • Minneapolis, Minnesota, 미국, 55407
        • 완전한
        • Allina Health Cancer Institute ( Site 0069)
    • Mississippi
      • Hattiesburg, Mississippi, 미국, 39401
        • 모병
        • Hattiesburg Clinic Hematology/Oncology ( Site 0104)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 601-261-1700
    • Nevada
      • Las Vegas, Nevada, 미국, 89106
        • 모병
        • Comprehensive Cancer Centers of Nevada ( Site 0015)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 702-952-3350
      • Reno, Nevada, 미국, 89502
        • 모병
        • Renown Regional Medical Center ( Site 0005)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 775-982-5050
    • New Jersey
      • Hackensack, New Jersey, 미국, 07601
        • 모병
        • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0082)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 551-996-5900
    • New Mexico
      • Albuquerque, New Mexico, 미국, 87109
        • 모병
        • New Mexico Oncology Hematology Consultants Ltd. ( Site 0019)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 505-842-8171
    • New York
      • Mineola, New York, 미국, 11501
        • 모병
        • Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0073)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 516-663-9500
      • New York, New York, 미국, 10016
        • 모병
        • Laura and Isaac Perlmutter Cancer Center ( Site 0003)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 212-731-6126
    • North Carolina
      • Garner, North Carolina, 미국, 27529
        • 완전한
        • Rex Hematology Oncology Associates - Garner ( Site 0071)
    • Tennessee
      • Nashville, Tennessee, 미국, 37203
        • 모병
        • SCRI Oncology Partners ( Site 7004)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 615-329-7274
      • Nashville, Tennessee, 미국, 37203
        • 모병
        • Tennessee Oncology ( Site 0018)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 877-836-6662
    • Texas
      • Dallas, Texas, 미국, 75231
        • 모병
        • Texas Oncology - DFW ( Site 8007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 214-739-4175
      • El Paso, Texas, 미국, 79902
        • 모병
        • Texas Oncology - West Texas ( Site 8004)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 915-747-4835
      • Houston, Texas, 미국, 77014
        • 모병
        • Kelsey-Seybold Clinic - North Houston Campus ( Site 0096)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 713-239-4510
      • Houston, Texas, 미국, 77025
        • 모병
        • Kelsey-Seybold Clinic ( Site 0040)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 713-239-4510
      • San Antonio, Texas, 미국, 78240
        • 모병
        • Texas Oncology - San Antonio ( Site 8001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 210-419-2608
    • Utah
      • Salt Lake City, Utah, 미국, 84112
        • 모병
        • University of Utah, Huntsman Cancer Institute ( Site 0056)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 801-587-7000
    • Virginia
      • Norfolk, Virginia, 미국, 23502
        • 모병
        • Virginia Oncology Associates (VOA) ( Site 8002)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 757-368-5033
    • Washington
      • Seattle, Washington, 미국, 98109
        • 모병
        • Fred Hutchinson Cancer Center ( Site 0042)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 206-606-6329
  • 벨기에
    • Flanders
      • Antwerp, Flanders, 벨기에, 2610
        • 모병
        • ZAS Sint Augustinus ( Site 3102)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 003234433759
    • Limburg
      • Genk, Limburg, 벨기에, 3600
        • 모병
        • Ziekenhuis Oost Limburg ( Site 3105)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 089 32 50 50
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, 벨기에, 9000
        • 모병
        • AZ Maria Middelares ( Site 3103)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +32 9 246 95 16
      • Ghent, Oost-Vlaanderen, 벨기에, 9000
        • 모병
        • UZ Gent ( Site 3101)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 09 332 20 15
  • 브라질
      • São Paulo, 브라질, 04014-002
        • 모병
        • IBCC - Núcleo de Pesquisa e Ensino ( Site 2306)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +55 11 4450 0300
    • Pernambuco
      • Recife, Pernambuco, 브라질, 50040-000
        • 모병
        • Hospital de Câncer de Recife ( Site 2300)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +558132178084
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, 브라질, 59062-000
        • 모병
        • Liga Norte Riograndense Contra o Cancer ( Site 2310)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +55 84 99817-0070
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, 브라질, 91350-200
        • 모병
        • Hospital Nossa Senhora da Conceição ( Site 2302)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +55 51 35160954
    • São Paulo
      • Barretos, São Paulo, 브라질, 14784-400
        • 모병
        • Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 2307)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +55 17 3321-6637
      • São Jose Do Rio Preto, São Paulo, 브라질, 15090-000
        • 모병
        • Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +55 (17) 3201-5054
  • 스페인
      • Barcelona, 스페인, 08003
        • 모병
        • Parc de Salut Mar - Hospital del Mar ( Site 4106)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 34932483860
      • Madrid, 스페인, 28007
        • 모병
        • Hospital Beata María Ana ( Site 4105)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 914097423/303
      • Madrid, 스페인, 28034
        • 모병
        • Hospital Universitario Ramon y Cajal ( Site 4103)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 913368263
    • Andalusia
      • Seville, Andalusia, 스페인, 41013
        • 모병
        • HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 4104)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 34955013068
    • Barcelona
      • L'Hospitalet de Llobregat, Barcelona, 스페인, 08908
        • 모병
        • ICO L Hospitalet ( Site 4101)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +34932607744
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, 스페인, 28040
        • 모병
        • Hospital Clinico San Carlos ( Site 4100)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 34913303000/7768
    • Valenciana, Comunitat
      • Valencia, Valenciana, Comunitat, 스페인, 46014
        • 모병
        • Hospital General Universitario de Valencia ( Site 4102)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 34963131800/438139
  • 아르헨티나
      • Mendoza, 아르헨티나, M5500AYB
        • 모병
        • Fundacion Centro Oncologico de Integración Regional ( Site 2400)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +54 9261 367 9497
    • Buenos Aires
      • Mar del Plata, Buenos Aires, 아르헨티나, B7600FZN
        • 모병
        • Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +54 9223 593 7663
      • Mar del Plata, Buenos Aires, 아르헨티나, C1426ANZ
        • 모병
        • Instituto Alexander Fleming ( Site 2402)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +541132218900
    • Córdoba Province
      • Córdoba, Córdoba Province, 아르헨티나, X5004BAL
        • 모병
        • Hospital Italiano de Cordoba ( Site 2406)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +543514106550
    • Río Negro Province
      • Viedma, Río Negro Province, 아르헨티나, R8500ACE
        • 모병
        • Clinica Viedma ( Site 2403)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 54 9351 592 3598
    • Santa Fe Province
      • Rosario, Santa Fe Province, 아르헨티나, S2000DEJ
        • 모병
        • Fundacion Estudios Clinicos ( Site 2405)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +54 9346 69 9922
      • Rosario, Santa Fe Province, 아르헨티나, S2002KDR
        • 모병
        • Hospital Provincial del Centenario ( Site 2410)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +543414307185
  • 영국
      • Birmingham, 영국, B15 2TH
        • 모병
        • Queen Elizabeth Hospital Birmingham ( Site 4017)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +441213718766
      • Cardiff, 영국, CF142TL
        • 모병
        • Velindre Cancer Centre Hospital ( Site 4008)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +442920615888
      • Leeds, 영국, LS9 7TF
        • 모병
        • St. James s University Hospital ( Site 4004)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +441132068186
    • Cornwall
      • Truro, Cornwall, 영국, TR13LJ
        • 모병
        • Royal Cornwall Hospital ( Site 4003)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +441872258342
    • London, City of
      • London, London, City of, 영국, EC1A7BE
        • 모병
        • St Bartholomew's Hospital ( Site 4001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 02073777000
      • London, London, City of, 영국, NW1 2PG
        • 모병
        • University College London Hospital ( Site 4007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +447977175703
    • Nottinghamshire
      • Nottingham, Nottinghamshire, 영국, NG51PB
        • 모병
        • Nottingham University Hospital NHS Trust ( Site 4009)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +441159691169
    • Somerset
      • Taunton, Somerset, 영국, TA1 5DA
        • 모병
        • Musgrove Park Hospital ( Site 4005)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +441823343634
  • 우크라이나
      • Kyiv, 우크라이나, 03126
        • 모병
        • Shalimov Institute of Surgery and Transplantation ( Site 4412)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380800333911
    • Cherkasy Oblast
      • Cherkasy, Cherkasy Oblast, 우크라이나, 18009
        • 모병
        • COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 4409)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380472319418
    • Ivano-Frankivsk Oblast
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, 우크라이나, 76018
        • 모병
        • Communal Non-Commercial Enterprise Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regio ( Site 4401)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380506601626
    • Kirovohrad Oblast
      • Kropyvnytskyi, Kirovohrad Oblast, 우크라이나, 25011
        • 모병
        • Ukrainian Center of Tomotherapy ( Site 4400)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380676239652
    • Lviv Oblast
      • Lviv, Lviv Oblast, 우크라이나, 79031
        • 모병
        • Lviv Oncology Regional Treatment and Diagnostic Center ( Site 4407)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380975814015
    • Rivne Oblast
      • Rivne, Rivne Oblast, 우크라이나, 33010
        • 모병
        • ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 4411)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380971921000
    • Vinnytsia Oblast
      • Vinnytsia, Vinnytsia Oblast, 우크라이나, 21029
        • 모병
        • Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 4413)
        • 연락하다:
          • Study Coordinator
          • 전화번호: + 380953105783
    • Volyn Oblast
      • Lutsk, Volyn Oblast, 우크라이나, 43018
        • 모병
        • ME "Volyn Regional Clinical Hospital" of the VRC ( Site 4415)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380503782998
    • Zakarpattia Oblast
      • Uzhhorod, Zakarpattia Oblast, 우크라이나, 88017
        • 모병
        • Uzhhorod Multispecialty City Clinical Hospital ( Site 4406)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +380506847086
  • 이스라엘
      • Haifa, 이스라엘, 3109601
        • 모병
        • Rambam Health Care Campus ( Site 3700)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +97247772688
      • Jerusalem, 이스라엘, 9103102
        • 모병
        • Shaare Zedek Medical Center ( Site 3704)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +97226555999
      • Petah Tikva, 이스라엘, 4941492
        • 모병
        • Rabin Medical Center ( Site 3702)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +97239377377
      • Ramat Gan, 이스라엘, 5265601
        • 모병
        • Sheba Medical Center ( Site 3701)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +97235303030
      • Tel Aviv, 이스라엘, 6423906
        • 모병
        • Sourasky Medical Center ( Site 3703)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +97236974444
  • 이탈리아
      • Bologna, 이탈리아, 40138
        • 모병
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 4605)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 390512144547
      • Genova, 이탈리아, 16132
        • 모병
        • Ospedale Policlinico San Martino ( Site 4606)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +390105600387
      • Milan, 이탈리아, 20132
        • 모병
        • IRCCS Ospedale San Raffaele ( Site 4600)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 390226436530
      • Milan, 이탈리아, 20133
        • 모병
        • Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 4601)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +39 02-2390-2849
      • Novara, 이탈리아, 28100
        • 모병
        • Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 4604)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 3903213732148
      • Padova, 이탈리아, 35128
        • 모병
        • Istituto Oncologico Veneto IRCCS ( Site 4603)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0498215523
      • Perugia, 이탈리아, 06129
        • 모병
        • Ospedale Santa Maria della Misericordia ( Site 4611)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +390755784308
      • Roma, 이탈리아, 00168
        • 모병
        • Policlincio Gemelli ( Site 4602)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0630158545
    • Catania
      • Misterbianco, Catania, 이탈리아, 95045
        • 모병
        • Humanitas Istituto Clinico Catanese ( Site 4610)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +3909573390197
    • Roma
      • Rome, Roma, 이탈리아, 00128
        • 모병
        • Istituto Nazionale Tumori Regina Elena ( Site 4607)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +39 0652665610
  • 일본
      • Akita, 일본, 010-8543
        • 모병
        • Akita University Hospital ( Site 5115)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-18-834-1111
      • Fukuoka, 일본, 811-1395
        • 모병
        • National Hospital Organization Kyushu Cancer Center ( Site 5119)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-92-541-3231
      • Fukushima, 일본, 960-1295
        • 모병
        • Fukushima Medical University Hospital ( Site 5101)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-24-547-1772
      • Hiroshima, 일본, 730-8518
        • 모병
        • Hiroshima City Hiroshima Citizens Hospital ( Site 5113)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-81-221-2291
      • Kagoshima, 일본, 892-0833
        • 모병
        • Social medical corporation Hakuaikai Sagara Hospital ( Site 5114)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-99-224-1800
      • Kyoto, 일본, 606-8507
        • 모병
        • Kyoto University Hospital ( Site 5110)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-75-751-3111
      • Okayama, 일본, 700-8558
        • 모병
        • Okayama University Hospital ( Site 5118)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-86-223-7151
      • Osaka, 일본, 541-8567
        • 모병
        • Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 5112)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-06-6945-1181
    • Aichi-ken
      • Nagoya, Aichi-ken, 일본, 467-8602
        • 모병
        • Nagoya City University Hospital ( Site 5108)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-52-851-5511
      • Nagoya, Aichi-ken, 일본, 464-8681
        • 모병
        • Aichi Cancer Center ( Site 5117)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-52-762-6111
    • Chiba
      • Kashiwa, Chiba, 일본, 277-8577
        • 모병
        • National Cancer Center Hospital East ( Site 5120)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-4-7133-1111
    • Ehime
      • Matsuyama, Ehime, 일본, 791-0280
        • 모병
        • National Hospital Organization Shikoku Cancer Center ( Site 5122)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-89-999-1111
    • Hokkaido
      • Sapporo, Hokkaido, 일본, 060-8648
        • 모병
        • Hokkaido University Hospital ( Site 5100)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-11-716-1161
    • Ishikawa-ken
      • Kahoku-gun, Ishikawa-ken, 일본, 920-0293
        • 모병
        • Kanazawa Medical University Hospital ( Site 5127)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-76-286-3511
    • Kanagawa
      • Isehara, Kanagawa, 일본, 259-1193
        • 모병
        • Tokai University Hospital ( Site 5107)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-463-93-1121
      • Kawasaki, Kanagawa, 일본, 216-8511
        • 모병
        • St. Marianna University Hospital ( Site 5124)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-44-977-8111
      • Sagamihara, Kanagawa, 일본, 252-0375
        • 모병
        • Kitasato University Hospital ( Site 5123)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-42-778-8111
      • Yokohama, Kanagawa, 일본, 241-8515
        • 모병
        • Kanagawa Cancer Center ( Site 5106)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-45-520-2222
    • Mie-ken
      • Tsu, Mie-ken, 일본, 514-8507
        • 모병
        • Mie University Hospital ( Site 5109)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-59-231-5246
    • Okinawa
      • Naha, Okinawa, 일본, 901-0154
        • 모병
        • Naha Nishi Clinic ( Site 5125)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-98-858-5557
    • Osaka
      • Suita, Osaka, 일본, 565-0871
        • 모병
        • The University of Osaka Hospital ( Site 5111)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-6-6210-8290
    • Saitama
      • Hidaka, Saitama, 일본, 350-1298
        • 모병
        • Saitama Medical University International Medical Center ( Site 5116)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-42-984-4111
    • Tokyo
      • Bunkyo, Tokyo, 일본, 113-8431
        • 모병
        • Juntendo University Hospital ( Site 5104)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-3-3813-3111
      • Koto, Tokyo, 일본, 135-8550
        • 모병
        • Cancer Institute Hospital of JFCR ( Site 5102)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-3-3520-0111
      • Minato, Tokyo, 일본, 105-8470
        • 모병
        • Toranomon Hospital ( Site 5126)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-3-3588-1111
      • Shinagawa, Tokyo, 일본, 142-8666
        • 모병
        • Showa Medical University Hospital ( Site 5103)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-3-3784-8000
      • Shinjuku, Tokyo, 일본, 162-8655
        • 모병
        • National Center for Global Health and Medicine ( Site 5105)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +81-3-3202-7181
      • Shinjuku, Tokyo, 일본, 160-0023
        • 모집하지 않고 적극적으로
        • Tokyo Medical University Hospital ( Site 5121)
  • 중국
    • Anhui
      • Bengbu, Anhui, 중국, 233004
        • 모병
        • The First Afflilated Hospital of Bengbu Medical College ( Site 5022)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0552-3085746
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, 중국, 400016
        • 모병
        • The First Affiliated Hospital of Chongqing Medical University ( Site 5039)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +86 023 89011606
      • Chongqing, Chongqing Municipality, 중국, 404000
        • 완전한
        • Chongqing University Three Gorges Hospital ( Site 5020)
    • Fujian
      • Xiamen, Fujian, 중국, 361003
        • 모병
        • The First Affiliated hospital of Xiamen University ( Site 5035)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0592-2137232
    • Guangdong
      • Guangzhou, Guangdong, 중국, 510060
        • 모병
        • Sun Yat-Sen University Cancer Center ( Site 5014)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 020-87343990
    • Guangxi
      • Nanning, Guangxi, 중국, 530201
        • 모병
        • Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +860771-5778582
    • Henan
      • Zhengzhou, Henan, 중국, 450008
        • 모병
        • Henan Cancer Hospital ( Site 5001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0371-65588404
    • Hubei
      • Wuhan, Hubei, 중국, 430030
        • 모병
        • Tongji Hospital Tongji Medical Science & Technology ( Site 5007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 027-83663940
      • Xiangyang, Hubei, 중국, 441021
        • 모병
        • Xiangyang Central Hospital ( Site 5017)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0710-2811523
    • Hunan
      • Changsha, Hunan, 중국, 410013
        • 모병
        • Hunan Cancer Hospital ( Site 5002)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0731-88651669
    • Jiangsu
      • Nanjing, Jiangsu, 중국, 210029
        • 모병
        • Jiangsu Province Hospital ( Site 5009)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 02568308145
      • Xuzhou, Jiangsu, 중국, 221009
        • 모병
        • Xuzhou Central Hospital ( Site 5036)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 051680812397
    • Jilin
      • Changchun, Jilin, 중국, 130021
        • 모병
        • The First Hospital of Jilin University ( Site 5003)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0431-88783330
      • Changchun, Jilin, 중국, 130015
        • 모병
        • Jilin Province Tumor Hospital ( Site 5040)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0431-80596018
    • Shaanxi
      • Xi'an, Shaanxi, 중국, 710061
        • 모병
        • The First Affiliated Hospital of Xi an Jiaotong University ( Site 5005)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +8602985324094
    • Shandong
      • Jinan, Shandong, 중국, 250013
        • 모병
        • Jinan Central Hospital ( Site 5031)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 053155865197
      • Linyi, Shandong, 중국, 276000
        • 모병
        • LinYi Cancer Hospital ( Site 5021)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +8605398127192
    • Shanxi
      • Taiyuan, Shanxi, 중국, 030000
        • 모병
        • Shanxi Cancer Hospital ( Site 5043)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 03514881611
    • Sichuan
      • Chengdu, Sichuan, 중국, 610041
        • 모병
        • Sichuan Cancer Hospital. ( Site 5018)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 028-85420251
      • Neijiang, Sichuan, 중국, 641099
        • 모병
        • The Second People's Hospital of Neijiang ( Site 5016)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +86 0832 2380771
    • Xinjiang
      • Ürümqi, Xinjiang, 중국, 830011
        • 모병
        • Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +8609917819133
    • Zhejiang
      • Hangzhou, Zhejiang, 중국, 310022
        • 모병
        • Zhejiang Cancer Hospital ( Site 5012)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0571-88122222
      • Hangzhou, Zhejiang, 중국, 310052
        • 모병
        • The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0571-89713252
      • Hangzhou, Zhejiang, 중국, 310003
        • 모병
        • The First Affiliated Hospital Zhejiang University School of Medicine ( Site 5026)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0571-87236855
      • Linhai, Zhejiang, 중국, 317000
        • 모병
        • Taizhou Hospital of Zhejiang Province ( Site 5029)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0576-85190467
  • 체코
      • Olomouc, 체코, 77900
        • 모병
        • Fakultni nemocnice Olomouc ( Site 3502)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420588444295
      • Prague, 체코, 140 59
        • 모병
        • Fakultni Thomayerova nemocnice ( Site 3506)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420261083733
      • Prague, 체코, 150 06
        • 모병
        • Fakultni nemocnice v Motole ( Site 3503)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420224434700
    • Moravian-Silesian Region
      • Ostrava - Poruba, Moravian-Silesian Region, 체코, 708 52
        • 모병
        • Fakultni nemocnice Ostrava ( Site 3505)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420597372124
    • Praha 2
      • Prague, Praha 2, 체코, 128 00
        • 모병
        • Vseobecna fakultni nemocnice v Praze ( Site 3501)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420224966764
    • South Moravian
      • Brno, South Moravian, 체코, 656 53
        • 모병
        • Masarykuv onkologicky ustav ( Site 3500)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +420543134003
  • 칠레
    • Biobio
      • Concepción, Biobio, 칠레, 4070196
        • 모병
        • Biocenter ( Site 2009)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +56412858421
    • Coquimbo Region
      • La Serena, Coquimbo Region, 칠레, 1720430
        • 모병
        • IC La Serena Research ( Site 2007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +56512386127
    • Region M. de Santiago
      • Santiago, Region M. de Santiago, 칠레, 7620002
        • 모병
        • Clínica UC San Carlos de Apoquindo ( Site 2008)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +569 5504 3334
      • Santiago, Region M. de Santiago, 칠레, 8420383
        • 모병
        • Bradfordhill ( Site 2001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +56978878489
      • Santiago, Region M. de Santiago, 칠레, 7500921
        • 모병
        • Fundación Arturo López Pérez ( Site 2000)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +56 9 6397 7440
    • Valparaiso
      • Viña del Mar, Valparaiso, 칠레, 2520598
        • 모병
        • ONCOCENTRO APYS ( Site 2005)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +56 9 92369820
  • 캐나다
    • Alberta
      • Edmonton, Alberta, 캐나다, T6G 1Z2
        • 모병
        • Cross Cancer Institute ( Site 0216)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 7804328644
    • Ontario
      • Oshawa, Ontario, 캐나다, L1G 2B9
        • 모병
        • Lakeridge Health ( Site 0217)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 905-576-8711
      • Toronto, Ontario, 캐나다, M5G 2M9
        • 모병
        • Princess Margaret Cancer Centre ( Site 0202)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 416-946-2000
      • Toronto, Ontario, 캐나다, M2K 1E1
        • 모병
        • North York General Hospital ( Site 0209)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 416-756-6000
    • Quebec
      • Chicoutimi, Quebec, 캐나다, G7H 5H6
        • 모병
        • CIUSSS- saguenay-Lac-Saint-Jean ( Site 0213)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 418-541-1000
      • Montreal, Quebec, 캐나다, H3T 1M5
        • 모병
        • St. Marys Hospital Center ( Site 0201)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 514-891-6904
      • Montreal, Quebec, 캐나다, H4A 3J1
        • 모병
        • McGill University Health Centre ( Site 0204)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 514-299-6425
      • Montreal, Quebec, 캐나다, H2X 3E4
        • 모병
        • Centre Hospitalier de l'Université de Montréal ( Site 0208)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 514-890-8444
      • Montreal, Quebec, 캐나다, H3T 1E2
        • 모집하지 않고 적극적으로
        • Jewish General Hospital ( Site 0203)
      • Québec, Quebec, 캐나다, G1S 4L8
        • 모병
        • Hopital Du Saint-Sacrement ( Site 0210)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 4186827511
    • Saskatchewan
      • Saskatoon, Saskatchewan, 캐나다, S7N 4H4
        • 모병
        • Saskatoon Cancer Centre ( Site 0215)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 306-655-2662
  • 콜롬비아
    • Antioquia
      • Medellín, Antioquia, 콜롬비아, 050021
        • 모병
        • Promotora Médica Las Américas S.A. ( Site 2206)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +576043421010x1089
    • Atlántico
      • Barranquilla, Atlántico, 콜롬비아, 080002
        • 모병
        • Centro Cancerologico del Caribe LTD ( Site 2209)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +57 3132121774
    • Bogota D.C.
      • Bogotá, Bogota D.C., 콜롬비아, 110131
        • 모병
        • FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +57 6017454421x90614
      • Bogotá, Bogota D.C., 콜롬비아, 111511
        • 모병
        • Instituto Nacional de Cancerologia ( Site 2211)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +5714817000X4301
    • Departamento de Córdoba
      • Montería, Departamento de Córdoba, 콜롬비아, 230002
        • 모집하지 않고 적극적으로
        • IMAT S.A.S ( Site 2202)
    • Risaralda Department
      • Pereira, Risaralda Department, 콜롬비아, 660001
        • 모병
        • Oncologos Del Occidente ( Site 2208)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 573154208077
  • 태국
      • Khon Kaen, 태국, 40002
        • 모병
        • Faculty of Medicine - Khon Kaen University ( Site 5802)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +6643363746
    • Bangkok
      • Bangkoknoi, Bangkok, 태국, 10700
        • 모병
        • Faculty of Medicine Siriraj Hospital ( Site 5800)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +6624192938
    • Changwat Songkhla
      • Hat Yai, Changwat Songkhla, 태국, 90110
        • 모병
        • Songklanagarind hospital ( Site 5801)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +6674451469
  • 터키 (Türkiye)
      • Adana, 터키 (Türkiye), 01140
        • 모병
        • Adana Medical Park Seyhan Hastanesi ( Site 4804)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +90 5056166338
      • Ankara, 터키 (Türkiye), 06230
        • 모병
        • Hacettepe Universite Hastaneleri ( Site 4800)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 903123052929
      • Ankara, 터키 (Türkiye), 06560
        • 모병
        • Gazi University Health Research and Application Center Gazi Hospital ( Site 4805)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 903122158710
      • Ankara, 터키 (Türkiye), 06800
        • 모병
        • Ankara Bilkent Şehir Hastanesi ( Site 4801)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0312 552 60 00
      • Istanbul, 터키 (Türkiye), 34722
        • 모병
        • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 4802)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 902167770000
      • Sakarya, 터키 (Türkiye), 54290
        • 모병
        • Sakarya Egitim Arastirma Hsatanesi ( Site 4809)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 90 505 478 5576
      • Samsun, 터키 (Türkiye), 55200
        • 모병
        • Samsun Medical Park Hastanesi ( Site 4810)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 444 44 84
    • İzmir
      • Bornova, İzmir, 터키 (Türkiye), 35100
        • 모병
        • Ege Universitesi Hastanesi ( Site 4803)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 0 232 343 4 343
  • 페루
      • Lima, 페루, 15036
        • 모병
        • Oncosalud ( Site 2600)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +5115137900
      • Lima, 페루, 15036
        • 모병
        • IPOR Instituto Peruano de Oncología & Radioterapia ( Site 2601)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +51 997881134
      • Lima, 페루, 15036
        • 모병
        • Clínica Internacional - Sede San Borja ( Site 2604)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +51 992004083
      • Lima, 페루, 15076
        • 모병
        • Hospital Militar Central Coronel Luis Arias Schereiber ( Site 2603)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +5112443453
  • 폴란드
    • Greater Poland Voivodeship
      • Poznan, Greater Poland Voivodeship, 폴란드, 61-866
        • 모병
        • Wielkopolskie Centrum Onkologii-Oddział Onkologii Klinicznej i Immunoonkologii z Pododdziałem Dzien ( Site 3811)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48618850620
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 폴란드, 85-796
        • 모병
        • Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 3802)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48523743525
    • Lesser Poland Voivodeship
      • Krakow, Lesser Poland Voivodeship, 폴란드, 30-727
        • 모병
        • Pratia MCM Krakow ( Site 3812)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48122954100
    • Masovian Voivodeship
      • Siedlce, Masovian Voivodeship, 폴란드, 08-110
        • 완전한
        • Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801)
      • Warsaw, Masovian Voivodeship, 폴란드, 02-781
        • 모병
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Site 3803)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 48225462522
      • Wieliszew, Masovian Voivodeship, 폴란드, 05-135
        • 모병
        • Mazowiecki Szpital Onkologiczny ( Site 3807)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48227661500
    • Podlaskie Voivodeship
      • Bialystok, Podlaskie Voivodeship, 폴란드, 15-027
        • 모병
        • Bialostockie Centrum Onkologii ( Site 3810)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48733100322
    • Pomeranian Voivodeship
      • Gdynia, Pomeranian Voivodeship, 폴란드, 81-519
        • 모병
        • Szpitale Pomorskie Sp. z o. o. ( Site 3805)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +48587260380
    • West Pomeranian Voivodeship
      • Koszalin, West Pomeranian Voivodeship, 폴란드, 75-581
        • 모병
        • Szpital Wojewodzki im.M.Kopernika. ( Site 3800)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 48943488931
  • 프랑스
      • Paris, 프랑스, 75015
        • 모병
        • Hôpital Européen Georges Pompidou ( Site 3011)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33156093577
      • Paris, 프랑스, 75014
        • 모병
        • Groupe Hospitalier Paris Saint Joseph ( Site 3010)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33144123577
    • Auvergne-Rhône-Alpes
      • Lyon, Auvergne-Rhône-Alpes, 프랑스, 69373
        • 모병
        • CENTRE LEON BERARD ( Site 3004)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33469856440
    • Haute-Vienne
      • Limoges, Haute-Vienne, 프랑스, 87000
        • 모병
        • Clinique Francois Chenieux ( Site 3006)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33555058606
    • Herault
      • Montpellier, Herault, 프랑스, 34298
        • 모병
        • Institut Regional du Cancer Montpellier ( Site 3009)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33(0)4 67 61 45 65
    • Loire-Atlantique
      • Saint-Herblain, Loire-Atlantique, 프랑스, 44805
        • 모병
        • Institut De Cancerologie De L Ouest ( Site 3003)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33240679900
    • Marne
      • Reims, Marne, 프랑스, 51100
        • 모병
        • Institut Jean Godinot ( Site 3002)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33326504444
    • Seine-Maritime
      • Rouen, Seine-Maritime, 프랑스, 76038
        • 모병
        • Centre Henri Becquerel ( Site 3001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33232082575
    • Var
      • Toulon, Var, 프랑스, 83800
        • 모병
        • HIA Sainte Anne ( Site 3007)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +33483162010
  • 핀란드
    • North Ostrobothnia
      • Oulu, North Ostrobothnia, 핀란드, 90220
        • 모병
        • Oulun yliopistollinen sairaala-Oncology and Hematology ( Site 3304)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +35883153038
    • Pirkanmaa
      • Tampere, Pirkanmaa, 핀란드, 33520
        • 모병
        • Tampereen yliopistollinen sairaala-Oncology ( Site 3302)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +358331166764
    • Uusimaa
      • Helsinki, Uusimaa, 핀란드, 00029
        • 모병
        • Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 3301)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +358947174900
  • 필리핀 제도
      • Iloilo City, 필리핀 제도, 5000
        • 모병
        • THE MEDICAL CITY ILOILO ( Site 5704)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +6333 3397340
    • Batangas
      • Lipa, Batangas, 필리핀 제도, 4217
        • 모병
        • Mary Mediatrix Medical Center ( Site 5702)
        • 연락하다:
          • Study Coordinator
          • 전화번호: (043) 773 6800
    • National Capital Region
      • Manila, National Capital Region, 필리핀 제도, 1000
        • 모병
        • Manila Doctors Hospital ( Site 5701)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +639985311606
  • 헝가리
      • Budapest, 헝가리, 1122
        • 모병
        • Országos Onkológiai Intézet-B-Belgyógyászati Onkológiai Osztály ( Site 3406)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +36122486003352
      • Budapest, 헝가리, 1082
        • 모병
        • Semmelweis Egyetem-Belgyógyászati és Onkológiai Klinika ( Site 3404)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +36 20 825 1756
      • Debrecen, 헝가리, 4032
        • 모병
        • Debreceni Egyetem Klinikai Kozpont ( Site 3411)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +3652255840
    • Bekes County
      • Gyula, Bekes County, 헝가리, 5700
        • 모병
        • Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 3405)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +36 66/526-526
    • Csongrád megye
      • Szeged, Csongrád megye, 헝가리, 6720
        • 모병
        • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3407)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +3662545404
    • Pest County
      • Budapest, Pest County, 헝가리, 1145
        • 모병
        • Budapesti Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 3408)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +36 1 467-3700/1245
  • 호주
    • New South Wales
      • Blacktown, New South Wales, 호주, 2148
        • 모병
        • Blacktown Hospital ( Site 5500)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +61298818000
    • Victoria
      • Frankston, Victoria, 호주, 3199
        • 모병
        • Peninsula Health Frankston Hospital ( Site 5501)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +61397848520
  • 홍콩
      • Hong Kong, 홍콩, 000000
        • 모병
        • Queen Mary Hospital ( Site 6000)
        • 연락하다:
          • Study Coordinator
          • 전화번호: 39103339
      • Hong Kong, 홍콩
        • 모병
        • Prince of Wales Hospital ( Site 6001)
        • 연락하다:
          • Study Coordinator
          • 전화번호: +852 3505 3555

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

18년 이상 (성인, 고령자)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

  • Has locally recurrent unresectable or metastatic TNBC that cannot be treated with curative intent
  • Has not received systemic treatment for locally recurrent unresectable or metastatic breast cancer
  • Participants previously treated for early-stage breast cancer must have completed all prior therapy for early-stage breast cancer with curative intent at least 6 months before the first disease recurrence
  • Is a candidate for treatment with pembrolizumab and one of the TPC options: paclitaxel or nab-paclitaxel or gemcitabine + carboplatin
  • Participants who have AEs due to previous anticancer therapies must have recovered to ≤Grade 1 or baseline with the exception of alopecia or vitiligo. Participants with endocrine-related AEs who are adequately treated with hormone replacement are eligible
  • Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load
  • Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

  • Has breast cancer amenable to treatment with curative intent
  • Has TNBC with evaluable tumor programmed death ligand 1 (PD-L1) expression at combined positive score (CPS) ≥10
  • Has received prior systemic therapy for treatment of locally recurrent unresectable or metastatic breast cancer
  • Has Grade ≥2 peripheral neuropathy
  • Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing
  • Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease
  • Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
  • Has skin only metastatic disease
  • Has advanced/metastatic, symptomatic visceral spread at risk of rapidly evolving into life-threatening complications
  • Human immunodeficiency virus (HIV)-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
  • Has known additional malignancy that is progressing or has required active treatment within the past 5 years
  • Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable
  • Active autoimmune disease that has required systemic treatment in the past 2 years. Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) is allowed
  • Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids, has current pneumonitis/ILD, or has suspected ILD or pneumonitis that cannot be ruled out by standard diagnostic assessments
  • Concurrent active Hepatitis B (defined as HBsAg positive and/or detectable HBV deoxyribonucleic acid (DNA)) and Hepatitis C virus (HCV) (defined as anti-HCV antibody (Ab) positive and detectable HCV ribonucleic acid (RNA)) infection
  • History of stem cell/solid organ transplant
  • Has not adequately recovered from major surgery or has ongoing surgical complications

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: Arm A: Sacituzumab Tirumotecan

Participants receive sacituzumab tirumotecan intravenously (IV) at a dose of 4 mg/kg every 2 weeks (Q2W) until disease progression, toxicity or discontinuation.
생물학적: Sacituzumab tirumotecan

IV Infusion

다른 이름들:
  • MK-2870
  • SAC-TMT
의약품: Rescue Medication

Participants receive the following pre-medications before sacituzumab tirumotecan infusion: Histamine-1 (H1) receptor agonist, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion. Participants are also recommended to receive prophylactic steroid mouthwash (dexamethasone or equivalent).
실험적: Arm B: Sacituzumab Tirumotecan + Pembrolizumab

Participants receive sacituzumab tirumotecan IV 4 mg/kg Q2W until disease progression, toxicity or discontinuation PLUS pembrolizumab IV 400 mg every 6 weeks (Q6W) for up to 18 administrations (up to ~2 years).
생물학적: Pembrolizumab

IV Infusion

다른 이름들:
  • MK-3475
  • 키트루다®
생물학적: Sacituzumab tirumotecan

IV Infusion

다른 이름들:
  • MK-2870
  • SAC-TMT
의약품: Rescue Medication

Participants receive the following pre-medications before sacituzumab tirumotecan infusion: Histamine-1 (H1) receptor agonist, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion. Participants are also recommended to receive prophylactic steroid mouthwash (dexamethasone or equivalent).
활성 비교기: Arm C: Treatment of Physician's Choice (TPC)

Participants receive physician's choice of chemotherapy agent(s): paclitaxel IV 80 mg/m^2 once every week (Q1W) OR paclitaxel IV 90 mg/m^2 on Days 1, 8, and 15, every 4 weeks (Q4W) OR nab-paclitaxel IV 100 mg/m^2 on Days 1, 8, and 15, Q4W OR gemcitabine IV 1000 mg/m^2 on Days 1 and 8, every 3 weeks (Q3W) PLUS carboplatin IV area under the curve (AUC) 2 mg/mL/min on Days 1 and 8, Q3W, until disease progression, toxicity or discontinuation.
의약품: Carboplatin

IV Infusion

다른 이름들:
  • 파라플라틴
의약품: Paclitaxel

IV Infusion

다른 이름들:
  • 탁솔
  • 온솔
의약품: Nab-paclitaxel

IV Infusion

다른 이름들:
  • 아브락산
의약품: Gemcitabine

IV Infusion

다른 이름들:
  • 젬자

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Progression-Free Survival (PFS) (sac-TMT versus treatment of physician's choice (TPC); sac-TMT plus pembrolizumab versus TPC)
기간: Up to ~39 months

PFS is defined as the time from randomization to the first documented progressive disease (PD) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) based on blinded independent central review (BICR) or death due to any cause, whichever occurs first. PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD.
Up to ~39 months
Overall Survival (OS) (sac-TMT versus TPC)
기간: Up to ~61 months

OS is defined as the time from randomization to death due to any cause.
Up to ~61 months

2차 결과 측정

결과 측정
측정값 설명
기간
Overall Survival (OS) (sac-TMT plus pembrolizumab versus treatment of physician's choice (TPC); sac-TMT plus pembrolizumab versus sac-TMT)
기간: Up to ~61 months

OS is defined as the time from randomization to death due to any cause.
Up to ~61 months
Progression-Free Survival (PFS) (sac-TMT plus pembrolizumab versus sac-TMT)
기간: Up to ~39 months

PFS is defined as the time from randomization to the first documented progressive disease (PD) per RECIST 1.1 based on BICR or death due to any cause, whichever occurs first. PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD.
Up to ~39 months
Objective Response Rate (ORR) (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Up to ~39 months

ORR is defined as the percentage of participants with Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per RECIST 1.1 based on BICR.
Up to ~39 months
Duration of Response (DOR)
기간: Up to ~39 months

For participants who demonstrate a confirmed Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per RECIST 1.1 based on BICR, DOR is defined as the time from first documented evidence of CR or PR until progressive disease (PD) or death, whichever occurs first. Per RECIST 1.1, PD is defined as at least a 20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. The appearance of one or more new lesions is also considered PD.
Up to ~39 months
Change from baseline in global health status/quality of life scores, on the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Baseline and up to ~61 months

The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to the questions "How would you rate your overall health during the past week?" and "How would you rate your overall quality of life during the past week?" are scored on a 7-point scale (1= Very poor to 7=Excellent). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better overall health status.
Baseline and up to ~61 months
Change from baseline in physical functioning score, on the EORTC QLQ-C30 (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Baseline and up to ~61 months

The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to questions about their physical functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better level of physical functioning.
Baseline and up to ~61 months
Change from baseline in emotional functioning score, on the EORTC QLQ-C30 (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Baseline and up to ~61 months

The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to questions about their emotional functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better level of emotional functioning.
Baseline and up to ~61 months
Change from baseline in fatigue score, on the EORTC QLQ-C30 (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Baseline and up to ~61 months

The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to questions about their fatigue are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better level of function.
Baseline and up to ~61 months
Change from baseline in diarrhea score, on the EORTC QLQ-C30 (sac-TMT versus TPC; sac-TMT plus pembrolizumab versus TPC)
기간: Baseline and up to ~61 months

The EORTC QLQ-C30 is a 30-item questionnaire to assess the overall quality of life of cancer patients. Participant responses to the question "Have you had diarrhea?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better level of function.
Baseline and up to ~61 months
Number of participants who experience one or more adverse events (AEs)
기간: Up to ~61 months

An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Up to ~61 months
Number of participants who discontinue study treatment due to an AE
기간: Up to ~61 months

An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Up to ~61 months

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

Merck Sharp & Dohme LLC

수사관

  • 연구 책임자: Medical Director, Merck Sharp & Dohme LLC

간행물 및 유용한 링크

연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.

일반 간행물

유용한 링크

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2025년 3월 16일

기본 완료 (추정된)

2030년 5월 18일

연구 완료 (추정된)

2030년 5월 18일

연구 등록 날짜

최초 제출

2025년 2월 18일

QC 기준을 충족하는 최초 제출

2025년 2월 18일

처음 게시됨 (실제)

2025년 2월 24일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 10월 13일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 10월 11일

마지막으로 확인됨

2026년 10월 1일

추가 정보

이 연구와 관련된 용어

키워드

추가 관련 MeSH 약관

기타 연구 ID 번호

  • 2870-011
  • MK-2870-011 (기타 식별자: MSD)
  • TroFuse-011 (기타 식별자: MSD)
  • U1111-1311-2310 (레지스트리 식별자: UTN)
  • 2024-516834-36-00 (레지스트리 식별자: EU CT)

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

예

IPD 계획 설명

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

예

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

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