Neural Mechanisms of Emotion-behaviour Interactions (EMOBB)
Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
연구 개요
연구 유형
등록 (추정된)
단계
- 해당 없음
연락처 및 위치
연구 연락처
- 이름: Jacqueline SCHOLL, PhD
- 전화번호: 4 81 10 65 00 + 33
- 이메일: jacqueline.scholl@inserm.fr
연구 장소
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Bron, 프랑스, 69500
- CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant)
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연락하다:
- Jacqueline SCHOLL, PhD
- 전화번호: + 33 4 81 10 65 00
- 이메일: jacqueline.scholl@inserm.fr
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수석 연구원:
- Jacqueline SCHOLL, PhD
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참여기준
자격 기준
공부할 수 있는 나이
- 성인
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
- being able to use both hands
- BMI between 18.5 and 30
- give written informed consen
- for women: contraception;
Exclusion Criteria:
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
- MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 무작위화되지 않음
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Task 1: self-organization under threat
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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실험적: Task 2: self-organization and learning
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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실험적: Task 3 : self-organization and social context
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Brain activity in regions of interest
기간: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Brain activity during task 1 (Self-organization under threat)
기간: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 2 (Self-organization and learning)
기간: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 3 (Self-organization and social context)
기간: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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공동 작업자 및 조사자
수사관
- 수석 연구원: Jacqueline SCHOLL, PhD, Institut National de la Santé Et de la Recherche Médicale, France
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
Functional Magnetic Resonance Imaging (fMRI)에 대한 임상 시험
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University of Wisconsin, MadisonNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Stanford University완전한
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University of Pennsylvania종료됨
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University Hospital, Bordeaux완전한
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Institut BergoniéRoche Pharma AG; Ligue contre le cancer, France완전한
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Centre hospitalier de l'Université de Montréal...Canadian Institutes of Health Research (CIHR); McGill University Health Centre/Research... 그리고 다른 협력자들모병
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Shanghai Ninth People's Hospital Affiliated to...모병