Neural Mechanisms of Emotion-behaviour Interactions (EMOBB)
Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Studietype
Registrering (Antatt)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiekontakt
- Navn: Jacqueline SCHOLL, PhD
- Telefonnummer: 4 81 10 65 00 + 33
- E-post: jacqueline.scholl@inserm.fr
Studiesteder
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Bron, Frankrike, 69500
- CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant)
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Ta kontakt med:
- Jacqueline SCHOLL, PhD
- Telefonnummer: + 33 4 81 10 65 00
- E-post: jacqueline.scholl@inserm.fr
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Hovedetterforsker:
- Jacqueline SCHOLL, PhD
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
Tar imot friske frivillige
Beskrivelse
Inclusion Criteria:
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
- being able to use both hands
- BMI between 18.5 and 30
- give written informed consen
- for women: contraception;
Exclusion Criteria:
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
- MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Ikke-randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Eksperimentell: Task 1: self-organization under threat
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Eksperimentell: Task 2: self-organization and learning
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Eksperimentell: Task 3 : self-organization and social context
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Brain activity in regions of interest
Tidsramme: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Brain activity during task 1 (Self-organization under threat)
Tidsramme: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 2 (Self-organization and learning)
Tidsramme: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 3 (Self-organization and social context)
Tidsramme: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Jacqueline SCHOLL, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Studierekorddatoer
Studer hoveddatoer
Studiestart (Antatt)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Andre studie-ID-numre
- 69HCL25_1123
- 2025-A02658-41 (Annen identifikator: ID-RCB)
Plan for individuelle deltakerdata (IPD)
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