Neural Mechanisms of Emotion-behaviour Interactions (EMOBB)
Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Type d'étude
Inscription (Estimé)
Phase
- N'est pas applicable
Contacts et emplacements
Coordonnées de l'étude
- Nom: Jacqueline SCHOLL, PhD
- Numéro de téléphone: 4 81 10 65 00 + 33
- E-mail: jacqueline.scholl@inserm.fr
Lieux d'étude
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Bron, France, 69500
- CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant)
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Contact:
- Jacqueline SCHOLL, PhD
- Numéro de téléphone: + 33 4 81 10 65 00
- E-mail: jacqueline.scholl@inserm.fr
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Chercheur principal:
- Jacqueline SCHOLL, PhD
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Adulte
Accepte les volontaires sains
La description
Inclusion Criteria:
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
- being able to use both hands
- BMI between 18.5 and 30
- give written informed consen
- for women: contraception;
Exclusion Criteria:
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
- MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Science basique
- Répartition: Non randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: Task 1: self-organization under threat
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Expérimental: Task 2: self-organization and learning
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Expérimental: Task 3 : self-organization and social context
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Brain activity in regions of interest
Délai: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Brain activity during task 1 (Self-organization under threat)
Délai: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 2 (Self-organization and learning)
Délai: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 3 (Self-organization and social context)
Délai: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Jacqueline SCHOLL, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Autres numéros d'identification d'étude
- 69HCL25_1123
- 2025-A02658-41 (Autre identifiant: ID-RCB)
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Informations sur les médicaments et les dispositifs, documents d'étude
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