Neural Mechanisms of Emotion-behaviour Interactions (EMOBB)
Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
Visão geral do estudo
Status
Condições
Intervenção / Tratamento
Tipo de estudo
Inscrição (Estimado)
Estágio
- Não aplicável
Contactos e Locais
Contato de estudo
- Nome: Jacqueline SCHOLL, PhD
- Número de telefone: 4 81 10 65 00 + 33
- E-mail: jacqueline.scholl@inserm.fr
Locais de estudo
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Bron, França, 69500
- CERMEP (Centre d'Etude de Recherche Multimodal et pluridisciplinaire en imagerie du vivant)
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Contato:
- Jacqueline SCHOLL, PhD
- Número de telefone: + 33 4 81 10 65 00
- E-mail: jacqueline.scholl@inserm.fr
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Investigador principal:
- Jacqueline SCHOLL, PhD
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
- Adulto
Aceita Voluntários Saudáveis
Descrição
Inclusion Criteria:
- 18-45 years old,
- fluent French speakers,
- healthy,
- without a beard at the time of testing,
- right-handed,
- being able to use both hands
- BMI between 18.5 and 30
- give written informed consen
- for women: contraception;
Exclusion Criteria:
- neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
- pregnancy or breast-feeding
- under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
- not wanting to be informed of abnormalities detected during MRI scan,
- taking part in other studies with exclusion periods,
- MRI exclusion criteria (cardiac pace maker etc, vascular or intracranial clamps or stents, neurological stimulator, any other metal in the body, past accidents with metal to the eyes, metallic prostheses, metal in the mouth (braces, retainers), medication pumps, any implants (e.g. hearing implants), piercings that cannot be removed, having worked with metal (other than radiography related to MRI) being claustrophobic, tatoos above the shoulders.
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Ciência básica
- Alocação: Não randomizado
- Modelo Intervencional: Atribuição Paralela
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
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Experimental: Task 1: self-organization under threat
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Experimental: Task 2: self-organization and learning
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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Experimental: Task 3 : self-organization and social context
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Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
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Brain activity in regions of interest
Prazo: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Brain activity during task 1 (Self-organization under threat)
Prazo: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 2 (Self-organization and learning)
Prazo: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Brain activity during task 3 (Self-organization and social context)
Prazo: Day 0
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Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
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Day 0
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Jacqueline SCHOLL, PhD, Institut National de la Santé Et de la Recherche Médicale, France
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Estimado)
Conclusão Primária (Estimado)
Conclusão do estudo (Estimado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Outros números de identificação do estudo
- 69HCL25_1123
- 2025-A02658-41 (Outro identificador: ID-RCB)
Plano para dados de participantes individuais (IPD)
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