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Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults

2026년 7월 23일 업데이트: Carlos Fernández-Morales, Universidad de Extremadura

Electromyographic Analysis of Immediate Neuromuscular Response After Low-Load Knee Extension Exercise With and Without Blood Flow Restriction in Healthy Adults

This pilot randomized contralateral within-participant study evaluated the immediate neuromuscular response to low-load knee extension exercise performed with and without blood flow restriction in healthy young adults.

Participants were randomized in a 1:1 ratio to one of two limb-allocation groups: blood flow restriction applied to the dominant limb or blood flow restriction applied to the non-dominant limb. In each participant, the contralateral limb completed the same exercise protocol without blood flow restriction. Therefore, all participants were assessed under both experimental conditions.

Both limb-specific conditions were completed during the same experimental session. The order of the blood flow restriction and non-blood flow restriction conditions was randomized for each participant, with a 10-minute rest period between conditions.

Blood flow restriction was applied using a pneumatic cuff positioned on the proximal thigh. Cuff pressure was individualized and set at 80% of the arterial occlusion pressure measured for the corresponding limb. Participants completed the same standardized low-load knee extension protocol under both conditions.

Surface electromyography was used to record vastus lateralis activity from each assessed limb during the exercise protocol. Muscle activity was primarily evaluated using root mean square amplitude normalized to the pre-exercise maximal voluntary isometric contraction recorded from the corresponding limb. Root mean square amplitude during maximal voluntary isometric contraction trials was also recorded before and immediately after each condition.

The study aimed to compare the electromyographic response between the blood flow restriction and non-blood flow restriction conditions and to determine whether this response differed according to whether blood flow restriction was applied to the dominant or non-dominant limb.

연구 개요

연구 유형

중재적

등록 (실제)

24

단계

  • 해당 없음

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연구 장소

    • Badajoz
      • Badajoz, Badajoz, 스페인, 06006
        • University of Extremadura

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

  • 성인
  • 고령자

건강한 자원 봉사자를 받아들입니다

예

설명

Inclusion Criteria:

  • Age between 18 and 65 years.
  • Healthy adults.
  • Absence of active pain or musculoskeletal injury in the lower limbs at the time of assessment.
  • Ability to understand the study procedures.
  • Voluntary agreement to participate and provision of written informed consent.

Exclusion Criteria:

  • History of neuromuscular disease.
  • History of cardiovascular disease.
  • History of peripheral vascular disease.
  • History of thromboembolic events.
  • Uncontrolled hypertension.
  • Skin lesions or skin conditions preventing placement of the blood flow restriction cuff or surface electromyography electrodes.
  • Recent lower limb surgery.
  • Pregnancy.
  • Any other contraindication to blood flow restriction exercise.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 기초 과학
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 하나의

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: Experimental: BFR allocated to the dominant limb
Participants received blood flow restriction on the dominant limb, while the contralateral non-dominant limb completed the same low-load knee extension protocol without blood flow restriction. Both limb-specific conditions were performed during the same experimental session in randomized order, with a 10-minute rest period between conditions. Blood flow restriction pressure was individualized and set at 80% of the arterial occlusion pressure of the corresponding limb. Vastus lateralis surface electromyography was recorded under both conditions.
Each participant completed the low-load knee extension exercise protocol separately with both lower limbs. Under each condition, the protocol comprised 75 repetitions distributed across four sets of 30, 15, 15, and 15 repetitions, with 30 seconds of rest between sets. One limb performed the protocol with blood flow restriction and the contralateral limb performed it without blood flow restriction. Condition order was randomized, and a 10-minute rest period was provided between the two limb-specific conditions. Vastus lateralis surface electromyography was recorded continuously during each protocol.
A pneumatic cuff was placed on the proximal thigh of the limb randomized to the blood flow restriction condition and inflated to 80% of the individualized arterial occlusion pressure during the low-load knee extension protocol. The cuff was not applied to the contralateral limb, which completed the same protocol under the non-blood flow restriction condition. The cuff was fully deflated and removed after completion of the blood flow restriction condition.
실험적: Experimental: BFR allocated to the non-dominant limb
Participants received blood flow restriction on the non-dominant limb, while the contralateral dominant limb completed the same low-load knee extension protocol without blood flow restriction. Both limb-specific conditions were performed during the same experimental session in randomized order, with a 10-minute rest period between conditions. Blood flow restriction pressure was individualized and set at 80% of the arterial occlusion pressure of the corresponding limb. Vastus lateralis surface electromyography was recorded under both conditions.
Each participant completed the low-load knee extension exercise protocol separately with both lower limbs. Under each condition, the protocol comprised 75 repetitions distributed across four sets of 30, 15, 15, and 15 repetitions, with 30 seconds of rest between sets. One limb performed the protocol with blood flow restriction and the contralateral limb performed it without blood flow restriction. Condition order was randomized, and a 10-minute rest period was provided between the two limb-specific conditions. Vastus lateralis surface electromyography was recorded continuously during each protocol.
A pneumatic cuff was placed on the proximal thigh of the limb randomized to the blood flow restriction condition and inflated to 80% of the individualized arterial occlusion pressure during the low-load knee extension protocol. The cuff was not applied to the contralateral limb, which completed the same protocol under the non-blood flow restriction condition. The cuff was fully deflated and removed after completion of the blood flow restriction condition.

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Vastus Lateralis Electromyographic Amplitude Normalized to Maximal Voluntary Isometric Contraction
기간: During the exercise protocol, within a single experimental session.
Surface electromyographic activity of the vastus lateralis was assessed during the low-load knee extension exercise protocol. The root mean square amplitude was normalized to the maximal voluntary isometric contraction recorded before exercise and expressed as percentage of maximal voluntary isometric contraction (%MVIC). Measurements were extracted at predefined time points across the four exercise sets in both experimental conditions.
During the exercise protocol, within a single experimental session.

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2026년 3월 3일

기본 완료 (실제)

2026년 4월 15일

연구 완료 (실제)

2026년 4월 15일

연구 등록 날짜

최초 제출

2026년 6월 12일

QC 기준을 충족하는 최초 제출

2026년 6월 12일

처음 게시됨 (실제)

2026년 6월 17일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 7월 27일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 7월 23일

마지막으로 확인됨

2026년 7월 1일

추가 정보

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기타 연구 ID 번호

  • 13

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