- ICH GCP
- US-Register für klinische Studien
- Klinische Studie NCT07654608
Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults
Electromyographic Analysis of Immediate Neuromuscular Response After Low-Load Knee Extension Exercise With and Without Blood Flow Restriction in Healthy Adults
This study evaluated the immediate neuromuscular response to low-load knee extension exercise performed with and without blood flow restriction in healthy young adults.
Blood flow restriction is a training method in which a pressure cuff is applied to the upper part of a limb to partially reduce blood flow during exercise. In this study, each participant completed the same knee extension exercise protocol under two conditions: with blood flow restriction and without blood flow restriction. The blood flow restriction pressure was individualized according to each participant's arterial occlusion pressure.
Surface electromyography was used to record the activity of the vastus lateralis muscle during the exercise protocol. Muscle activation was mainly assessed using the root mean square amplitude normalized to a maximal voluntary isometric contraction measured before exercise. Maximal voluntary isometric contraction was also recorded before and after the protocol to explore immediate changes in maximal muscle activation.
The study was conducted in healthy adults and aimed to compare the electromyographic response between the blood flow restriction and non-restriction conditions during a standardized low-load exercise task.
Studienübersicht
Status
Intervention / Behandlung
Studientyp
Einschreibung (Tatsächlich)
Phase
- Unzutreffend
Kontakte und Standorte
Studienorte
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Badajoz
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Badajoz, Badajoz, Spanien, 06006
- University of Extremadura
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Teilnahmekriterien
Zulassungskriterien
Studienberechtigtes Alter
- Erwachsene
- Älterer Erwachsener
Akzeptiert gesunde Freiwillige
Beschreibung
Inclusion Criteria:
- Age between 18 and 65 years.
- Healthy adults.
- Absence of active pain or musculoskeletal injury in the lower limbs at the time of assessment.
- Ability to understand the study procedures.
- Voluntary agreement to participate and provision of written informed consent.
Exclusion Criteria:
- History of neuromuscular disease.
- History of cardiovascular disease.
- History of peripheral vascular disease.
- History of thromboembolic events.
- Uncontrolled hypertension.
- Skin lesions or skin conditions preventing placement of the blood flow restriction cuff or surface electromyography electrodes.
- Recent lower limb surgery.
- Pregnancy.
- Any other contraindication to blood flow restriction exercise.
Studienplan
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Grundlegende Wissenschaft
- Zuteilung: Zufällig
- Interventionsmodell: Crossover-Aufgabe
- Maskierung: Single
Waffen und Interventionen
Teilnehmergruppe / Arm |
Intervention / Behandlung |
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Experimental: Low-load knee extension exercise with blood flow restriction
Participants performed a low-load knee extension exercise protocol with blood flow restriction applied to the proximal thigh.
The blood flow restriction pressure was individualized and set at 80% of the participant's arterial occlusion pressure.
Surface electromyography of the vastus lateralis was recorded throughout the exercise protocol.
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Participants completed a low-load knee extension exercise protocol consisting of 75 repetitions distributed across four sets: 30, 15, 15, and 15 repetitions.
Surface electromyography of the vastus lateralis was recorded continuously during the protocol.
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Aktiver Komparator: Low-load knee extension exercise without blood flow restriction
Participants performed the same low-load knee extension exercise protocol without blood flow restriction.
Surface electromyography of the vastus lateralis was recorded throughout the exercise protocol.
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Participants completed a low-load knee extension exercise protocol consisting of 75 repetitions distributed across four sets: 30, 15, 15, and 15 repetitions.
Surface electromyography of the vastus lateralis was recorded continuously during the protocol.
A pneumatic cuff was placed on the proximal thigh and inflated to 80% of the participant's individualized arterial occlusion pressure during the low-load knee extension exercise protocol.
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Was misst die Studie?
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Vastus Lateralis Electromyographic Amplitude Normalized to Maximal Voluntary Isometric Contraction
Zeitfenster: During the exercise protocol, within a single experimental session.
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Surface electromyographic activity of the vastus lateralis was assessed during the low-load knee extension exercise protocol.
The root mean square amplitude was normalized to the maximal voluntary isometric contraction recorded before exercise and expressed as percentage of maximal voluntary isometric contraction (%MVIC).
Measurements were extracted at predefined time points across the four exercise sets in both experimental conditions.
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During the exercise protocol, within a single experimental session.
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Mitarbeiter und Ermittler
Sponsor
Studienaufzeichnungsdaten
Haupttermine studieren
Studienbeginn (Tatsächlich)
Primärer Abschluss (Tatsächlich)
Studienabschluss (Tatsächlich)
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst gepostet (Tatsächlich)
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Zuletzt verifiziert
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Andere Studien-ID-Nummern
- 13
Arzneimittel- und Geräteinformationen, Studienunterlagen
Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt
Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt
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