Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones (TACTIK)
The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise).
The main questions we seek to answer are:
- Does the supplement save cognitive performance under stress compared to a placebo?
- Does the supplement improve marksmanship under stress compared to a placebo?
연구 개요
상세 설명
In this study, 20 active SWAT team members will be randomized into two groups: Exogenous Ketone Supplement (EKS) and Placebo (PLA).
Participants will complete the trial in a crossover manner (meaning each participant will complete both EKS and PLA conditions)
Our primary outcome of interest is changes in cognitive performance following an exhaustive exercise bout. Secondary outcomes include: changes in marksmanship accuracy and speed, and changes in select biomarkers (catecholamines, cortisol, and BDNF).
Although ketone supplements are marketed for energy and cognitive performance, little is known about how they affect biological markers during stressful environments. Findings from this study may help inform safe, evidence-based use of such supplements among tactical athletes.
연구 유형
등록 (추정된)
단계
- 해당 없음
연락처 및 위치
연구 연락처
- 이름: Michael J Ormsbee, PhD
- 전화번호: 850-644-2194
- 이메일: mormsbee@fsu.edu
연구 장소
-
-
Florida
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Tallahassee, Florida, 미국, 32306
- 모병
- Institute of Sports Sciences and Medicine
-
연락하다:
- Michael J Ormsbee, PhD
- 전화번호: 850-644-2194
- 이메일: mormsbee@fsu.edu
-
수석 연구원:
- Michael J Ormsbee, PhD
-
부수사관:
- Connor R McKay
-
부수사관:
- Andrew P Koutnik, PhD
-
-
참여기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Active Member of an accredited Law Enforcement Special Weapons and Tactics Team (SWAT)
- Health and capable of meeting testing requirements
Exclusion Criteria:
- Following a low-carbohydrate ketogenic diet
- Self-reported Pregnancy
- Allergy to testing materials
- Currently using exogenous ketone supplements within one week of testing
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 다른
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 삼루타
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: KetoneIQ®
Supplement of study.
KetoneIQ® dosed at 0.6g/kg body weight
|
Acute dosage at 0.6g/kg of bodyweight, split into 2 boluses of 0.4 and 0.2g/kg seperated by 45 mins
|
|
위약 비교기: Placebo
Flavor, texture, color matched.
Very low calorie.
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Taste, texture, and color matched very low calorie placebo
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Cognitive Performance
기간: Baseline (minute 0) to Post Suppelementation (minute 45) to Post Exercise (minute 60)
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Changes in Score for the Trail Making Test, Psychomotor Vigilance Test, and Flanker Test.
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Baseline (minute 0) to Post Suppelementation (minute 45) to Post Exercise (minute 60)
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Changes in Circulating Concentration of Brain Derieved Neurotrophic Factor
기간: Baseline (minute 0) to post supplementation (minute 45) to post exercise (minute 60)
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To assess changes in BDNF from baseline to post supplementation to post exercise
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Baseline (minute 0) to post supplementation (minute 45) to post exercise (minute 60)
|
|
Changes in Circulating Catecholamines Concetrations
기간: From baseline (minute 0) to post supplemenation (minute 45) to post exercise (minute 60)
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To assess changes in the circulating concentration of epinephrine, norepinephrine, and dopamine
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From baseline (minute 0) to post supplemenation (minute 45) to post exercise (minute 60)
|
|
Changes in Circulating Cortisol Concentration
기간: From baseline (minute 0) to post supplemetation (minute 45) to post exercise (minute 60)
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To assess changes in circulating cortisol between groups
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From baseline (minute 0) to post supplemetation (minute 45) to post exercise (minute 60)
|
|
Weapons Familarization Score
기간: Post Exercise (minute 60)
|
To assess whether potentially improved cognitive performance translates to tactical-specific tasks.
Rifle disassembly, reassembly, and functions check.
This will be quantified by number of errors and time to completion
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Post Exercise (minute 60)
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Marksmanship efficiency
기간: Post Exercise (minute 60)
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To determine whether potentially improved cognitive performance translates to live-round marksmanship.
Using HIT Factor scoring (an aggregate of accuracy and time to completion, where a higher number is better), we will assess both accuracy and speed to completion for a shuttle fire drill
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Post Exercise (minute 60)
|
공동 작업자 및 조사자
수사관
- 수석 연구원: Michael J Ormsbee, PhD, Florida State University
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
키워드
기타 연구 ID 번호
- STUDY00007647: TACTIK
- FP00009695 (기타 보조금/기금 번호: Health Via Modern Nutrition)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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