Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments
Cornelius J Clancy, Hong Huang, Shaoji Cheng, Hartmut Derendorf, M Hong Nguyen, Cornelius J Clancy, Hong Huang, Shaoji Cheng, Hartmut Derendorf, M Hong Nguyen
Abstract
We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.
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Source: PubMed