Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments

Abstract

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

Figures

FIG.1.

Kill curves for time-kill (A) and postantifungal effect (B) experiments on C. albicans S. The kill curves at 0.25 times the MIC are not presented but did not show reductions in colony counts from the starting inocula.

FIG.2.

Kill curves for time-kill (A) and postantifungal effect (B) experiments on C. parapsilosis 1. The kill curves at 0.25 times the MIC are not presented but did not show reductions in colony counts from the starting inocula.