Cost of preventing variceal rebleeding with transjugular intrahepatic portal systemic shunt and distal splenorenal shunt
Thomas D Boyer, J Michael Henderson, Adrienne M Heerey, Susana Arrigain, Vicky Konig, Jason Connor, Kareem Abu-Elmagd, John Galloway, Layton F Rikkers, Lennox Jeffers, DIVERT Study Group, J Michael Henderson, David S Barnes, Michael Geisinger, Mark Sands, Susan Curtas, Thomas D Boyer, John R Galloway, Enrique Martinez, Qiang Cai, Louis G Martin, Joanne Halcomb, Sharon Behan, Alicia Whitcher, Lennox Jeffers, Enrique G Molina, Arie Regev, Joe U Levi, Alan S Livingstone, Jorge Guerra Jr, Jeffrey Raskin, K Rajender Reddy, Eugene R Schiff, Andreas Tzakis, Jose Yrizarry, Edward Russell, Thomas Scagnelli, Joy Ness, Adrianna Arcila, Amy Siebert, Kareem Abu-Elmagd, Kapil B Chopra, Albert Zajko, John J Fung, Geoffrey Bond, F Leland Thaete, C Andrew Bonham, Hugo Vargas, Diane Morton, Darlene Koritsky, Holly Chapman, Cindy Blaha, Layton F Rikkers, Kevin Block, Michael Lucey, Munci Kalayoglu, Myron Wojtowycz, Ian Sproat, Deb Chicks, Janice Cooney, Michael Kutner, Jason Connor, Marlene Goormastic, Susana Arrigain, Adrienne Heerey, Vicky Konig, Debbie Bick, Thomas D Boyer, Adrienne Heerey, Douglas Labrecque, Donald Jensen, Theodore Karrison, Jeanne LaBerge, Roger Jenkins, Patricia Robuck, Thomas D Boyer, J Michael Henderson, Adrienne M Heerey, Susana Arrigain, Vicky Konig, Jason Connor, Kareem Abu-Elmagd, John Galloway, Layton F Rikkers, Lennox Jeffers, DIVERT Study Group, J Michael Henderson, David S Barnes, Michael Geisinger, Mark Sands, Susan Curtas, Thomas D Boyer, John R Galloway, Enrique Martinez, Qiang Cai, Louis G Martin, Joanne Halcomb, Sharon Behan, Alicia Whitcher, Lennox Jeffers, Enrique G Molina, Arie Regev, Joe U Levi, Alan S Livingstone, Jorge Guerra Jr, Jeffrey Raskin, K Rajender Reddy, Eugene R Schiff, Andreas Tzakis, Jose Yrizarry, Edward Russell, Thomas Scagnelli, Joy Ness, Adrianna Arcila, Amy Siebert, Kareem Abu-Elmagd, Kapil B Chopra, Albert Zajko, John J Fung, Geoffrey Bond, F Leland Thaete, C Andrew Bonham, Hugo Vargas, Diane Morton, Darlene Koritsky, Holly Chapman, Cindy Blaha, Layton F Rikkers, Kevin Block, Michael Lucey, Munci Kalayoglu, Myron Wojtowycz, Ian Sproat, Deb Chicks, Janice Cooney, Michael Kutner, Jason Connor, Marlene Goormastic, Susana Arrigain, Adrienne Heerey, Vicky Konig, Debbie Bick, Thomas D Boyer, Adrienne Heerey, Douglas Labrecque, Donald Jensen, Theodore Karrison, Jeanne LaBerge, Roger Jenkins, Patricia Robuck
Abstract
Background/aims: We examined the cost and cost effectiveness of distal splenorenal shunt (DSRS) and transjugular intrahepatic portosystemic shunt (TIPS) in the prevention of variceal rebleeding.
Methods: Patients participated in a randomized controlled trial comparing DSRS to TIPS. Quality of life (QOL) was measured using SF-36 preceding randomization and yearly thereafter. Cost utility analysis was performed using TreeAge DATA. Costs for both in- and out-patient events and interventions were obtained for each patient. Costs using coated stents were estimated using different rates of stenosis. Incremental cost effectiveness ratios (ICERs) were determined at 1, 3 and 5 years.
Results: The average yearly costs of managing patients after TIPS and DSRS over 5 years were similar, $16,363 and $13,492, respectively. Cost of TIPS for surviving patients exceeded the cost of DSRS at years 3 and 5 but not significantly. ICERs per life saved favored TIPS at year 5 ($61,000). If coated rather than bare stents were used the cost effectiveness of TIPS increased slightly.
Conclusions: TIPS is as effective as DSRS in preventing variceal rebleeding and may be more cost effective. TIPS, in all aspects, is equal to DSRS in the prevention of variceal rebleeding in patients who are medical failures.
Trial registration: ClinicalTrials.gov NCT00006161.
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Source: PubMed