- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00006161
Decompression Intervention of Variceal Rebleeding Trial (DIVERT)
Decompression Intervention of Variceal Rebleeding Trial
The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis.
This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment
Phase
- Phase 3
Contacts and Locations
Study Locations
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Florida
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Miami, Florida, United States, 31336
- University of Miami School of Medicine
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Georgia
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Atlanta, Georgia, United States, 30322
- Emory University
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Ohio
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Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
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Pennsylvania
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Pittsburgh, Pennsylvania, United States, 15213
- University of Pittsburgh Medical Center
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Wisconsin
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Madison, Wisconsin, United States, 53792
- University of Wisconsin
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Variceal bleeding secondary to cirrhosis and portal hypertension
- Child's Class A or B cirrhosis of any etiology
- Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy
Exclusion Criteria:
- Prior shunt procedure
- Portal vein thrombosis
- Polycystic liver disease
- Intractable ascites
- Prior organ transplant
- Any medical intractable disease
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
Collaborators and Investigators
Investigators
- Principal Investigator: J. Michael Henderson, M.D., The Cleveland Clinic
- Principal Investigator: Thomas D. Boyer, M.D., Emory University
- Principal Investigator: Lennox Jeffers, M.D., University of Miami
- Principal Investigator: Enrique Molina, M.D., University of Miami
- Principal Investigator: Layton F. Rikkers, M.D., University of Wisconsin, Madison
- Principal Investigator: Kareem Abu-Elmagd, M.D., University of Pittsburgh Medical Center
- Principal Investigator: Amrik Shah, Sc.D., Cleveland Clinic Foundation - Data Coordinating Center
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- DIVERT (completed)
- DK50680-02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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