Dose-Response Oxidation of Ingested Phytoglycogen during Exercise in Endurance-Trained Men
Arash Bandegan, Li Huang, Fred J Longstaffe, Peter Wr Lemon, Arash Bandegan, Li Huang, Fred J Longstaffe, Peter Wr Lemon
Abstract
Background: Phytoglycogen (PHY; PhytoSpherix; Mirexus Biotechnologies), a highly branched polysaccharide extracted from sweet corn, has considerable potential for exercise oxidation due to its low viscosity in water, high water retention, and exceptional stability.
Objectives: Using gas chromatography-isotope ratio mass spectrometry, we investigated dose-response oxidation of ingested PHY during prolonged, moderate-intensity exercise.
Methods: Thirteen men (≥1 y endurance-training experience, ≥6 d·wk-1, ∼1-1.5 h·d-1; age, 25.7 ± 5.5 y; mass, 79.3 ± 10.0 kg; V̇O2max, 59.9 ± 5.5 mL·kg-1·min-1; means ± SDs) cycled for 150 min (50% maximal watt output) while ingesting PHY concentrations of 0.0% (0.0 g·min-1), 3.6% (0.5 g·min-1), 7.2% (1.0 g·min-1), 10.8% (1.5 g·min-1), or 14.4% (2 g·min-1) in water (2100 mL) (n = 7-10/dose). Substrate oxidation was determined using stable-isotope methods and indirect calorimetry.
Results: PHY oxidation plateaued between 60 and 150 min of exercise and increased (P < 0.001) from 0.49 to 0.72 g·min-1 with 0.5- and 1.0-g·min-1 doses without further increases (0.76 and 0.73 g·min-1; P > 0.05) with 1.5 or 2 g·min-1. Peak PHY oxidation (0.84 ± 0.04 g·min-1) occurred in the final 30 min of exercise with 2 g·min-1. Exercise blood glucose was greater (5.1 mmol·L-1) with 1.0-, 1.5-, and 2-g·min-1 doses compared with that of 0.5 (4.7 mmol·L-1) or 0.0 g·min-1 (4.2 mmol·L-1) (P < 0.0001). Gastrointestinal distress was minimal except with 2 g·min-1 (P < 0.001).
Conclusions: In male endurance athletes, PHY oxidation plateaued at 0.72-0.76 g·min-1 during 150 min of cycling at 50% Wmax (peak oxidation of 0.84 g·min-1 occurred during the final 30 min). This trial was registered at clinicaltrials.gov as NCT02909881.
Keywords: carbohydrate; endurance exercise; gastric emptying; osmolality; stable isotope.
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
Source: PubMed