Diagnosis of Periodontal Disease Using Genetic Marker in Saliva

Inclusion Criteria:

A. Severe Periodontal Disease

• Patients with chronic severe periodontitis
• Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
• subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

A. Moderate Periodontal Disease

• Patients with chronic moderate periodontitis
• Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
• subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

C. Healthy Control

• Healthy periodontal patients ( more than 20 permanent teeth are present , in all parts of deep periodontal pockets measuring 4mm or less, and height is 2mm or less clinical attachment person)
• subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing

Exclusion Criteria:

• Received periodontal treatment within the last six months
• recently taken antibiotics within 3 months if you need a prescription antibiotic prophylaxis
• taking the drug can affect periodontal status for a long period of time
• pregnant or breastfeeding
• In case of oral inflammatory mucosal disease (Lichen planus, etc.)
• A history of alcoholism or drug abuse if
• other special systemic disease (high blood pressure)
• ages under 18