Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

Knee Stability Training for Knee Osteoarthritis (OA)

23. januar 2013 oppdatert av: University of Pittsburgh

Knee Stability Training in Individuals With Knee Osteoarthritis

People with knee osteoarthritis (OA) frequently complain of knee instability. This study will test whether certain exercises can improve knee stability, reduce pain, and improve physical function in people with knee OA.

Study hypotheses: 1) Participants in the stability training group will demonstrate less pain and higher levels of physical function, based on self-report measures of pain and function (WOMAC, Lower Extremity Function Scale), and less time to complete the Get Up and Go test, a physical performance measure of function. 2) During walking and the step down task, participants in the stability training group will demonstrate greater knee motion during weight bearing, greater vertical ground reaction forces and loading rates, and reduced ratios of co-contraction between quadriceps/hamsting and tibialis anterior/gastrocnemius muscle pairs compared to the standard group. Participants in the stability group will also demonstrate greater step lengths, single limb support times, and average walking velocity compared to the standard group.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Traditional exercise therapy for knee OA primarily focuses on lower limb strength and joint motion deficits. Recent evidence has suggested that changes in lower limb biomechanical factors during weight bearing activities may have substantial impact on physical function and disease progression in individuals with knee OA. The effectiveness of exercise therapy programs might be improved by incorporating balance and agility training techniques (knee stability training). The aim of this trial is to test the effectiveness of supplementing traditional exercise therapy with knee stability training techniques tailored for individuals with knee OA.

Participants will be randomly assigned to one of two groups. The first group will participate in a standard rehabilitation program of traditional exercise therapy for knee OA. The second group will participate in a standard rehabilitation program supplemented with a knee stability program. Study visits will occur at study entry, 2 months, 6 months, and 1 year. At each study visit, changes in pain, physical function, and biomechanical factors will be assessed. This study will last for one year.

Studietype

Intervensjonell

Registrering (Faktiske)

231

Fase

  • Fase 2

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Forente stater
    • Pennsylvania
      • Pittsburgh, Pennsylvania, Forente stater, 15260
        • University of Pittsburgh, Department of Physical Therapy, School of Health and Rehabilitation Sciences

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

40 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • Meet the 1986 American College of Rheumatology (ACR) clinical criteria for knee osteoarthritis
  • Grade II or greater Kellgren and Lawrence radiographic changes

Exclusion Criteria:

  • History of two or more falls within the year prior to study entry
  • Unable to walk a distance of 100 feet without an assistive device or a rest period
  • Total knee arthroplasty
  • Uncontrolled hypertension
  • History of cardiovascular disease
  • History of neurological disorders that affect lower extremity function such as stroke or peripheral neuropathy
  • Corticosteroid injection to the quadriceps or patellar tendon in the past month, or 3 or more within the past year
  • Quadriceps tendon rupture, patellar tendon rupture, or patellar fracture that could place them at risk of re-injury during quadriceps strength testing
  • Pregnancy

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: Randomisert
  • Intervensjonsmodell: Parallell tildeling
  • Masking: Trippel

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: 1
Traditional exercise program supplemented with knee stability training activities
Annen: Knee stability training
The addition of agility and perturbation training techniques to the traditional exercise program
Aktiv komparator: 2
Traditional exercise program
Annen: Traditional exercise therapy for knee osteoarthritis
Exercises include stretching, strengthening, and aerobic exercise

Hva måler studien?

Primære resultatmål

Resultatmål
Tidsramme
Western Ontario and McMaster OA index (WOMAC)
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year
Lower Extremity Function Scale
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year
Get Up and Go test (a physical performance measure of function)
Tidsramme: Measured at baseline, 2 months, 6 months
Measured at baseline, 2 months, 6 months
Knee Outcome Survey - Activities of Daily Living Scale
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year

Sekundære resultatmål

Resultatmål
Tidsramme
Cartilage morphology changes as measured by MRI
Tidsramme: Measured at baseline, 1 year
Measured at baseline, 1 year
Physical Activity Scale for the Elderly
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year
Quadriceps strength and activation
Tidsramme: Measured at baseline, 2 months, 6 months
Measured at baseline, 2 months, 6 months
Radiographic severity of OA
Tidsramme: Measured at baseline, 1 year
Measured at baseline, 1 year
Fear Avoidance questionnaire for the knee
Tidsramme: Measured at baseline, 2months, 6 months, 1 year
Measured at baseline, 2months, 6 months, 1 year
Beck Anxiety Index
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year
Center for Epidemiological Studies Depression Scale
Tidsramme: Measured at baseline, 2 months, 6 months, 1 year
Measured at baseline, 2 months, 6 months, 1 year
Motion analysis variables (knee motion, vertical ground reaction force, loading rates, knee adduction/abduction moment, and lower extremity muscle co-contractions during walking and a step-down task)
Tidsramme: Measured at baseline, 2 months, 6 months
Measured at baseline, 2 months, 6 months

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

University of Pittsburgh

Samarbeidspartnere

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Etterforskere

  • Hovedetterforsker: G. Kelley Fitzgerald, PhD, PT, University of Pittsburgh, Department of Physical Therapy, School of Health and Rehabilitation Sciences

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. april 2004

Primær fullføring (Faktiske)

1. desember 2008

Studiet fullført (Faktiske)

1. desember 2008

Datoer for studieregistrering

Først innsendt

3. mars 2004

Først innsendt som oppfylte QC-kriteriene

3. mars 2004

Først lagt ut (Anslag)

4. mars 2004

Oppdateringer av studieposter

Sist oppdatering lagt ut (Anslag)

24. januar 2013

Siste oppdatering sendt inn som oppfylte QC-kriteriene

23. januar 2013

Sist bekreftet

1. januar 2013

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • NIAMS-117
  • R01AR048760-01A2 (U.S. NIH-stipend/kontrakt)

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere