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Rituximab og Bendamustine Hydrochloride, Rituximab og Ibrutinib, eller Ibrutinib alene i behandling av eldre pasienter med tidligere ubehandlet kronisk lymfatisk leukemi

21. oktober 2026 oppdatert av: National Cancer Institute (NCI)

En randomisert fase III-studie av Bendamustine Plus Rituximab versus Ibrutinib Plus Rituximab Versus Ibrutinib alene hos ubehandlede eldre pasienter (>/= 65 år) med kronisk lymfatisk leukemi (KLL)

This randomized phase III trial studies rituximab with bendamustine hydrochloride or ibrutinib to see how well they work compared to ibrutinib alone in treating older patients with previously untreated chronic lymphocytic leukemia. Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Chemotherapy drugs, such as bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It is not yet known whether rituximab with bendamustine hydrochloride may work better than rituximab and ibrutinib or ibrutinib alone in treating chronic lymphocytic leukemia.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVE:

I. To determine whether progression free survival (PFS) is superior after therapy with bendamustine hydrochloride (bendamustine) in combination with rituximab, ibrutinib alone, or ibrutinib in combination with rituximab in patients age 65 or older with previously untreated chronic lymphocytic leukemia (CLL).

SECONDARY OBJECTIVES:

I. To determine 2-year PFS in each of the three treatment arms. II. To determine which treatment arm produces superior overall survival (OS). III. To determine the complete response (CR) rate, complete and nodular partial response (CR/nPR) rate, and overall response (PR+nPR+CR) rate (ORR) among the three treatment arms and compare these arms.

IV. To determine the impact of minimal residual disease (MRD)-negative disease at time of CR documentation and at 2 years on PFS and OS in each of the treatment arms.

V. To determine duration of response after each of the three treatments and compare these treatment arms.

VI. To determine toxicity and tolerability of the three treatment regimens. VII. To determine response and PFS of patients initially on the bendamustine in combination with rituximab arm who cross over to ibrutinib.

OTHER PRE-SPECIFIED OBJECTIVES:

I. To determine whether baseline cytogenetic markers, Zap-70 methylation, IgVH mutational status, or select deoxyribonucleic acid (DNA) mutations predict outcomes or time to response in these three arms.

II. To determine whether local fluorescence in situ hybridization (FISH) results for del(11q22.3) and del(17p13.1) are consistent with central analysis.

III. To determine whether baseline micro ribonucleic acid (RNA) and gene expression markers are correlated with clinical outcomes of interest (e.g. progression-free and alive at 2 years versus not), as well as to explore changes in microRNA expression from baseline to post-treatment time points, with a focus on those with persistent lymphocytosis and relapse.

IV. To determine whether eradication of MRD predicts longer duration of response with standard therapy and ibrutinib-based regimens.

V. To describe the baseline functional status, comorbid medical conditions, and number of medications of older CLL patients who meet criteria for therapy.

VI. To determine how functional status changes with therapy using baseline to 3-month evaluation and end-of-study/2-year evaluation; to determine whether this change is different among the treatment groups.

VII. To determine whether geriatric assessment variables known to be associated with chemotherapy toxicity in other disease groups can also predict therapy-associated toxicity in the CLL population.

VIII. To assess whether the FCGR3A polymorphism (rs396991) is correlated with depth of response (MRD status) to ibrutinib plus rituximab after 6 cycles, with secondary endpoints CR rate, rapidity of response, and progression-free survival (PFS).

IX. To assess whether C1QA polymorphism (rs172378) is correlated with MRD status, CR rate, rapidity of response, and PFS.

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM I: Patients receive rituximab intravenously (IV) on day 1 (day 0 course 1) and bendamustine hydrochloride IV over 30 minutes on days 1-2. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients experiencing disease progression may crossover to Arm II.

ARM II: Patients receive ibrutinib orally (PO) daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM III: Patients receive ibrutinib as in Arm II. Patients receive rituximab IV on days 1, 8, 15, and 22 of course 2 and on day 1 of courses 3-6. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Additionally, patients undergo bone marrow aspiration and biopsy, blood sample collection, and computed tomography (CT) throughout the study.

After completion of study treatment, patients are followed up every 6 months for up to 10 years.

Studietype

Intervensjonell

Registrering (Faktiske)

547

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 5G2
    - Arthur J E Child Comprehensive Cancer Centre
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - QEII Health Sciences Centre/Nova Scotia Health Authority
- Ontario
  - Greater Sudbury, Ontario, Canada, P3E 5J1
    - Health Sciences North
  - Hamilton, Ontario, Canada, L8V 5C2
    - Juravinski Cancer Centre at Hamilton Health Sciences
  - Kingston, Ontario, Canada, K7L 2V7
    - Kingston Health Sciences Centre
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Newmarket, Ontario, Canada, L3Y 2P9
    - Stronach Regional Health Centre at Southlake
  - Oshawa, Ontario, Canada, L1G 2B9
    - Lakeridge Health Oshawa
  - Ottawa, Ontario, Canada, K1H 8L6
    - Ottawa Hospital and Cancer Center-General Campus
  - Toronto, Ontario, Canada, M4C 3E7
    - Michael Garron Hospital
  - Toronto, Ontario, Canada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M3M 0B2
    - Humber River Hospital
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - CSSS Champlain-Charles Le Moyne
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Montreal, Quebec, Canada, H2X 3E4
    - CHUM - Centre Hospitalier de l'Universite de Montreal
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forente stater
- Alabama
  - Birmingham, Alabama, Forente stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forente stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forente stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forente stater, 99504
    - Anchorage Radiation Therapy Center
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Regional Hospital
- Arizona
  - Phoenix, Arizona, Forente stater, 85054
    - Mayo Clinic Hospital in Arizona
  - Scottsdale, Arizona, Forente stater, 85259
    - Mayo Clinic in Arizona
  - Tucson, Arizona, Forente stater, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, Forente stater, 85719
    - University of Arizona Cancer Center-North Campus
  - Yuma, Arizona, Forente stater, 85364
    - Onvida Health Yuma Medical Center
- Arkansas
  - Hot Springs, Arkansas, Forente stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forente stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Anaheim, California, Forente stater, 92806
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forente stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Arroyo Grande, California, Forente stater, 93420
    - PCR Oncology
  - Auburn, California, Forente stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forente stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Baldwin Park, California, Forente stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forente stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forente stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forente stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Concord, California, Forente stater, 94520
    - John Muir Medical Center-Concord
  - Davis, California, Forente stater, 95616
    - Sutter Davis Hospital
  - Duarte, California, Forente stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Fontana, California, Forente stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forente stater, 94538
    - Kaiser Permanente-Fremont
  - Fresno, California, Forente stater, 93720
    - Kaiser Permanente-Fresno
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forente stater, 94904
    - Marin General Hospital
  - Harbor City, California, Forente stater, 90710
    - Kaiser Permanente South Bay
  - Irvine, California, Forente stater, 92618
    - Kaiser Permanente-Irvine
  - Los Angeles, California, Forente stater, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, Forente stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forente stater, 90034
    - Kaiser Permanente West Los Angeles
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forente stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94611
    - Kaiser Permanente-Oakland
  - Palo Alto, California, Forente stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forente stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forente stater, 91402
    - Kaiser Permanente - Panorama City
  - Redwood City, California, Forente stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forente stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forente stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forente stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forente stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forente stater, 95825
    - Kaiser Permanente Sacramento Medical Center
  - San Diego, California, Forente stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forente stater, 92134
    - Naval Medical Center -San Diego
  - San Francisco, California, Forente stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forente stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose, California, Forente stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Jose, California, Forente stater, 95124
    - Stanford Cancer Center South Bay
  - San Leandro, California, Forente stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forente stater, 92078
    - Kaiser Permanente-San Marcos
  - San Rafael, California, Forente stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forente stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forente stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forente stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forente stater, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente-South San Francisco
  - St. Helena, California, Forente stater, 94574
    - Saint Helena Hospital
  - Stockton, California, Forente stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forente stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forente stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forente stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forente stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forente stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forente stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Whittier, California, Forente stater, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland Hills, California, Forente stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forente stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forente stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Forente stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forente stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forente stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forente stater, 80222
    - Western States Cancer Research NCORP
  - Denver, Colorado, Forente stater, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Forente stater, 80210
    - AdventHealth Porter
  - Durango, Colorado, Forente stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forente stater, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Forente stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forente stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forente stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forente stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Greeley, Colorado, Forente stater, 80631
    - Banner North Colorado Medical Center
  - Greenwood Village, Colorado, Forente stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lafayette, Colorado, Forente stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forente stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Forente stater, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Forente stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forente stater, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Forente stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forente stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forente stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forente stater, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Parker, Colorado, Forente stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Parker, Colorado, Forente stater, 80138
    - AdventHealth Parker
  - Pueblo, Colorado, Forente stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forente stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forente stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Forente stater, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Danbury, Connecticut, Forente stater, 06810
    - Danbury Hospital
  - Derby, Connecticut, Forente stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forente stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Guilford, Connecticut, Forente stater, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Forente stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Middletown, Connecticut, Forente stater, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Forente stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forente stater, 06520
    - Yale University
  - North Haven, Connecticut, Forente stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwalk, Connecticut, Forente stater, 06856
    - Norwalk Hospital
  - Orange, Connecticut, Forente stater, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Torrington, Connecticut, Forente stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, Forente stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forente stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forente stater, 06385
    - Smilow Cancer Hospital Care Center - Waterford
  - West Haven, Connecticut, Forente stater, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forente stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forente stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forente stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forente stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forente stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forente stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forente stater, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Forente stater, 20007
    - MedStar Georgetown University Hospital
- Florida
  - Altamonte Springs, Florida, Forente stater, 32701
    - AdventHealth Altamonte
  - Deerfield Beach, Florida, Forente stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Jacksonville, Florida, Forente stater, 32207
    - Baptist MD Anderson Cancer Center
  - Jupiter, Florida, Forente stater, 33458
    - Jupiter Medical Center
  - Kissimmee, Florida, Forente stater, 34744
    - AdventHealth Kissimmee
  - Miami, Florida, Forente stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forente stater, 32806
    - Orlando Health Cancer Institute
  - Orlando, Florida, Forente stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forente stater, 32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando, Florida, Forente stater, 32822
    - AdventHealth East Orlando
  - Pensacola, Florida, Forente stater, 32504
    - Sacred Heart Hospital
  - Plantation, Florida, Forente stater, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Weston, Florida, Forente stater, 33331
    - Cleveland Clinic-Weston
  - Winter Park, Florida, Forente stater, 32792
    - AdventHealth Winter Park
- Georgia
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forente stater, 30342
    - Northside Hospital
  - Columbus, Georgia, Forente stater, 31904
    - John B Amos Cancer Center
  - Cumming, Georgia, Forente stater, 30041
    - Northside Hospital-Forsyth
- Hawaii
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forente stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forente stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forente stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Lihue, Hawaii, Forente stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Forente stater, 96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea, Hawaii, Forente stater, 96701
    - The Cancer Center of Hawaii-Pali Momi
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Coeur d'Alene, Idaho, Forente stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Fruitland, Idaho, Forente stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forente stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forente stater, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, Forente stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forente stater, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Forente stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Forente stater, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Forente stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forente stater, 61701
    - OSF Saint Joseph Medical Center
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forente stater, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forente stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Danville, Illinois, Forente stater, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Decatur, Illinois, Forente stater, 62526
    - Heartland Cancer Research NCORP
  - Effingham, Illinois, Forente stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forente stater, 62401
    - Carle Physician Group-Effingham
  - Elk Grove Village, Illinois, Forente stater, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forente stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forente stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forente stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Highland Park, Illinois, Forente stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Highland Park, Illinois, Forente stater, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Hinsdale, Illinois, Forente stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Joliet, Illinois, Forente stater, 60435
    - Duly Health and Care Joliet
  - Kankakee, Illinois, Forente stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Libertyville, Illinois, Forente stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forente stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forente stater, 60153
    - Loyola University Medical Center
  - Monmouth, Illinois, Forente stater, 61462
    - Illinois CancerCare-Monmouth
  - Mount Vernon, Illinois, Forente stater, 62864
    - SSM Health Good Samaritan
  - New Lenox, Illinois, Forente stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - Normal, Illinois, Forente stater, 61761
    - Carle Cancer Institute Normal
  - O'Fallon, Illinois, Forente stater, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forente stater, 61350
    - Radiation Oncology of Northern Illinois
  - Ottawa, Illinois, Forente stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forente stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Forente stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forente stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forente stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - Quincy, Illinois, Forente stater, 62301
    - Quincy Medical Group-Clinic
  - Rockford, Illinois, Forente stater, 61114
    - UW Health Carbone Cancer Center Rockford
  - Skokie, Illinois, Forente stater, 60076
    - North Shore Medical Center
  - Springfield, Illinois, Forente stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forente stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forente stater, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Forente stater, 62781
    - Springfield Memorial Hospital
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forente stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forente stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Forente stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Crown Point, Indiana, Forente stater, 46307
    - Michiana Hematology Oncology PC-Crown Point
  - Elkhart, Indiana, Forente stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forente stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forente stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forente stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Kokomo, Indiana, Forente stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forente stater, 46350
    - IU Health La Porte Hospital
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forente stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forente stater, 46545
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forente stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Plymouth, Indiana, Forente stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forente stater, 47374
    - Reid Health
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consortium
  - Westville, Indiana, Forente stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic - Ames
  - Boone, Iowa, Forente stater, 50036
    - McFarland Clinic - Boone
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forente stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forente stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forente stater, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Forente stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forente stater, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Forente stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forente stater, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Fort Dodge, Iowa, Forente stater, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Iowa City, Iowa, Forente stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Iowa City, Iowa, Forente stater, 52246
    - Iowa City VA Healthcare System
  - Jefferson, Iowa, Forente stater, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Forente stater, 50158
    - McFarland Clinic - Marshalltown
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forente stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forente stater, 51104
    - Saint Luke's Regional Medical Center
  - Spencer, Iowa, Forente stater, 51301
    - Abben Cancer Center
  - Waterloo, Iowa, Forente stater, 50702
    - MercyOne Waterloo Cancer Center
  - West Des Moines, Iowa, Forente stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forente stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forente stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forente stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forente stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forente stater, 67601
    - HaysMed
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forente stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forente stater, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67905
    - Cancer Center of Kansas-Liberal
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forente stater, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, Forente stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forente stater, 66762
    - Mercy Hospital Pittsburg
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forente stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forente stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Forente stater, 40004
    - CommonSpirit Saint Joseph Hospital - Bardstown
  - Corbin, Kentucky, Forente stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Crestview Hills, Kentucky, Forente stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Lexington, Kentucky, Forente stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forente stater, 40509
    - CommonSpirit Saint Joseph Medical Center - East Lexington
  - Louisville, Kentucky, Forente stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forente stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forente stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Shepherdsville, Kentucky, Forente stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forente stater, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Forente stater, 70433
    - Mary Bird Perkins Cancer Center - Covington
  - Houma, Louisiana, Forente stater, 70360
    - Mary Bird Perkins Cancer Center - Houma
  - Kenner, Louisiana, Forente stater, 70065
    - Ochsner Medical Center Kenner
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Medical Center Jefferson
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forente stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Forente stater, 04856
    - Penobscot Bay Medical Center
  - York Village, Maine, Forente stater, 03909
    - York Hospital
- Maryland
  - Baltimore, Maryland, Forente stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forente stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forente stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forente stater, 21229
    - Saint Agnes Hospital
  - Cumberland, Maryland, Forente stater, 21502
    - UPMC Western Maryland
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Memorial Hospital
  - Randallstown, Maryland, Forente stater, 21133
    - Northwest Hospital Center
  - Salisbury, Maryland, Forente stater, 21801
    - TidalHealth Peninsula Regional
- Massachusetts
  - Beverly, Massachusetts, Forente stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forente stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forente stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forente stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forente stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Clinic
  - Fitchburg, Massachusetts, Forente stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Gloucester, Massachusetts, Forente stater, 01930
    - Addison Gilbert Hospital
  - Newton, Massachusetts, Forente stater, 02462
    - Newton-Wellesley Hospital
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
  - Springfield, Massachusetts, Forente stater, 01107
    - D'Amour Center for Cancer Care
  - Winchester, Massachusetts, Forente stater, 01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester, Massachusetts, Forente stater, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forente stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Ann Arbor, Michigan, Forente stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forente stater, 48706
    - McLaren Cancer Institute-Bay City
  - Brownstown, Michigan, Forente stater, 48183
    - Henry Ford Cancer Institute-Downriver
  - Clarkston, Michigan, Forente stater, 48346
    - McLaren Cancer Institute-Clarkston
  - Clinton Township, Michigan, Forente stater, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Commerce, Michigan, Forente stater, 48382
    - Huron Valley-Sinai Hospital
  - Dearborn, Michigan, Forente stater, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Forente stater, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forente stater, 48236
    - Henry Ford Health Saint John Hospital
  - Escanaba, Michigan, Forente stater, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Farmington Hills, Michigan, Forente stater, 48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills, Michigan, Forente stater, 48336
    - Corewell Health Farmington Hills Hospital
  - Flint, Michigan, Forente stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forente stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forente stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Grand Rapids, Michigan, Forente stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forente stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grosse Pointe, Michigan, Forente stater, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Lansing, Michigan, Forente stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forente stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forente stater, 48446
    - McLaren Cancer Institute-Lapeer Region
  - Livonia, Michigan, Forente stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forente stater, 48043
    - McLaren Cancer Institute-Macomb
  - Mount Pleasant, Michigan, Forente stater, 48858
    - McLaren Cancer Institute-Central Michigan
  - Muskegon, Michigan, Forente stater, 49444
    - Trinity Health Muskegon Hospital
  - Novi, Michigan, Forente stater, 48377
    - Henry Ford Medical Center-Columbus
  - Novi, Michigan, Forente stater, 48374
    - Henry Ford Health Providence Novi Hospital
  - Petoskey, Michigan, Forente stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forente stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Port Huron, Michigan, Forente stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forente stater, 49677
    - Corewell Health Reed City Hospital
  - Roseville, Michigan, Forente stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forente stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forente stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forente stater, 48073
    - Oakland Medical Group
  - Royal Oak, Michigan, Forente stater, 48067
    - Oakland Colon Rectal Associates
  - Royal Oak, Michigan, Forente stater, 48073
    - Hematology Oncology Consultants PC-Royal Oak
  - Royal Oak, Michigan, Forente stater, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Forente stater, 48601
    - MyMichigan Medical Center Saginaw
  - Southfield, Michigan, Forente stater, 48075
    - Henry Ford Health Providence Southfield Hospital
  - Sterling Heights, Michigan, Forente stater, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Forente stater, 48314
    - Mitchell Folbe MD PC
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forente stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forente stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forente stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Troy, Michigan, Forente stater, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Forente stater, 48093
    - Henry Ford Health Warren Hospital
  - West Bloomfield, Michigan, Forente stater, 48322
    - Henry Ford West Bloomfield Hospital
- Minnesota
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forente stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, Forente stater, 55417
    - Minneapolis VA Medical Center
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Jackson, Mississippi, Forente stater, 39216
    - University of Mississippi Medical Center
- Missouri
  - Bolivar, Missouri, Forente stater, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Forente stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forente stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Chesterfield, Missouri, Forente stater, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Forente stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia, Missouri, Forente stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Forente stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forente stater, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forente stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forente stater, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Forente stater, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Hospital
  - Rolla, Missouri, Forente stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Forente stater, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forente stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forente stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forente stater, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - Sullivan, Missouri, Forente stater, 63080
    - Missouri Baptist Sullivan Hospital
- Montana
  - Billings, Montana, Forente stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59102
    - Montana Cancer Consortium NCORP
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forente stater, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Forente stater, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Forente stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forente stater, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, Forente stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forente stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68122
    - Hematology and Oncology Consultants PC
  - Papillion, Nebraska, Forente stater, 68046
    - Midlands Community Hospital
- Nevada
  - Henderson, Nevada, Forente stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forente stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forente stater, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Forente stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forente stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forente stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forente stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forente stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forente stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forente stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forente stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forente stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forente stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forente stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forente stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forente stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forente stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forente stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forente stater, 89120
    - Nevada Cancer Research Foundation NCORP
  - Las Vegas, Nevada, Forente stater, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Forente stater, 89183
    - OptumCare Cancer Care at Fort Apache
  - Reno, Nevada, Forente stater, 89503
    - Saint Mary's Regional Medical Center
- New Hampshire
  - Concord, New Hampshire, Forente stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Derry, New Hampshire, Forente stater, 03038
    - Parkland Medical Center
  - Dover, New Hampshire, Forente stater, 03820
    - Wentworth-Douglass Hospital
  - Laconia, New Hampshire, Forente stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forente stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forente stater, 03103
    - Solinsky Center for Cancer Care
  - Manchester, New Hampshire, Forente stater, 03104
    - Dartmouth Cancer Center - Manchester/ DCC Manchester
  - Nashua, New Hampshire, Forente stater, 03063
    - Dartmouth Cancer Center - Nashua
  - Portsmouth, New Hampshire, Forente stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - East Orange, New Jersey, Forente stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Englewood, New Jersey, Forente stater, 07631
    - Englewood Hospital and Medical Center
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Paramus, New Jersey, Forente stater, 07652
    - The Valley Hospital - Luckow Pavilion
  - Plainsboro, New Jersey, Forente stater, 08536
    - Penn Medicine Princeton Health
  - Ridgewood, New Jersey, Forente stater, 07450
    - Valley Health System Ridgewood Campus
  - Summit, New Jersey, Forente stater, 07902
    - Overlook Hospital
  - Westwood, New Jersey, Forente stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forente stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forente stater, 88011
    - Memorial Medical Center-Las Cruces
- New York
  - Auburn, New York, Forente stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Brooklyn, New York, Forente stater, 11219
    - Maimonides Medical Center
  - Buffalo, New York, Forente stater, 14263
    - Roswell Park Cancer Institute
  - Camillus, New York, Forente stater, 13031
    - Hematology Oncology Associates of CNY at Camillus
  - East Syracuse, New York, Forente stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forente stater, 12801
    - Glens Falls Hospital
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forente stater, 11030
    - North Shore University Hospital
  - Middletown, New York, Forente stater, 10940
    - Garnet Health Medical Center
  - New York, New York, Forente stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - Plattsburgh, New York, Forente stater, 12901
    - Champlain Valley Physicians Hospital Medical Center
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rome, New York, Forente stater, 13440
    - Hematology Oncology Associates of Central New York-Rome
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forente stater, 13210
    - State University of New York Upstate Medical University
  - Utica, New York, Forente stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital
  - Asheville, North Carolina, Forente stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Forente stater, 28806
    - Messino Cancer Centers
  - Asheville, North Carolina, Forente stater, 28801
    - Mountain Radiation Oncology PA
  - Asheville, North Carolina, Forente stater, 28803
    - AdventHealth Infusion Center Asheville
  - Brevard, North Carolina, Forente stater, 28712
    - Transylvania Regional Hospital
  - Chapel Hill, North Carolina, Forente stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Clinton, North Carolina, Forente stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clinton, North Carolina, Forente stater, 28328
    - Sampson Radiation Oncology
  - Durham, North Carolina, Forente stater, 27710
    - Duke University Medical Center
  - Franklin, North Carolina, Forente stater, 28734
    - Angel Medical Center
  - Goldsboro, North Carolina, Forente stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Radiation Oncology
  - Greenville, North Carolina, Forente stater, 27834
    - East Carolina University
  - Hendersonville, North Carolina, Forente stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forente stater, 28792
    - AdventHealth Hendersonville
  - Jacksonville, North Carolina, Forente stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forente stater, 28546
    - Onslow Memorial Hospital
  - Kinston, North Carolina, Forente stater, 28501
    - ECU Health Oncology Kinston
  - Marion, North Carolina, Forente stater, 28752
    - Mission Hospital McDowell
  - Pinehurst, North Carolina, Forente stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Spruce Pine, North Carolina, Forente stater, 28777
    - Blue Ridge Regional Hospital
  - Statesville, North Carolina, Forente stater, 28677
    - Iredell Memorial Hospital
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forente stater, 27104
    - Southeast Clinical Oncology Research Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forente stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Broadway Medical Center
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forente stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forente stater, 44307
    - Cleveland Clinic Akron General
  - Beachwood, Ohio, Forente stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Beachwood, Ohio, Forente stater, 44122
    - Cleveland Clinic Cancer Center Beachwood
  - Belpre, Ohio, Forente stater, 45714
    - Strecker Cancer Center-Belpre
  - Bowling Green, Ohio, Forente stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Centerville, Ohio, Forente stater, 45459
    - Miami Valley Hospital South
  - Chardon, Ohio, Forente stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forente stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forente stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forente stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forente stater, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Forente stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forente stater, 45230
    - Oncology Hematology Care Inc-Anderson
  - Cincinnati, Ohio, Forente stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forente stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forente stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forente stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forente stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forente stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forente stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forente stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forente stater, 44035
    - Mercy Cancer Center-Elyria
  - Fairfield, Ohio, Forente stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forente stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Lancaster Radiation Oncology
  - Lima, Ohio, Forente stater, 45804
    - Lima Memorial Hospital
  - Mansfield, Ohio, Forente stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Mayfield Heights, Ohio, Forente stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mayfield Heights, Ohio, Forente stater, 44124
    - UH Seidman Cancer Center at Landerbrook Health Center
  - Mentor, Ohio, Forente stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Forente stater, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forente stater, 43055
    - Newark Radiation Oncology
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forente stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forente stater, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, Forente stater, 45504
    - Springfield Regional Medical Center
  - Strongsville, Ohio, Forente stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forente stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forente stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forente stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forente stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forente stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forente stater, 43608
    - Mercy Health - Saint Vincent Hospital
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Warrensville Heights, Ohio, Forente stater, 44122
    - South Pointe Hospital
  - Wauseon, Ohio, Forente stater, 43567
    - Fulton County Health Center
  - West Chester, Ohio, Forente stater, 45069
    - University of Cincinnati Cancer Center-West Chester
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forente stater, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Wooster, Ohio, Forente stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Forente stater, 45433
    - Wright-Patterson Medical Center
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forente stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forente stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
  - Tulsa, Oklahoma, Forente stater, 74146
    - Warren Clinic Oncology-Tulsa
  - Tulsa, Oklahoma, Forente stater, 74136
    - Saint Francis Children's Hospital
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forente stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forente stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forente stater, 97420
    - Bay Area Hospital
  - Milwaukie, Oregon, Forente stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forente stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forente stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Kaiser Permanente Northwest
- Pennsylvania
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Forente stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forente stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forente stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Drexel Hill, Pennsylvania, Forente stater, 19026
    - Delaware County Memorial Hospital
  - East Stroudsburg, Pennsylvania, Forente stater, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, Forente stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forente stater, 17522
    - Ephrata Community Hospital
  - Gettysburg, Pennsylvania, Forente stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forente stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hanover, Pennsylvania, Forente stater, 17331
    - WellSpan Medical Oncology and Hematology
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forente stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Johnstown, Pennsylvania, Forente stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - McKeesport, Pennsylvania, Forente stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Forente stater, 19063
    - Riddle Memorial Hospital
  - Moon Township, Pennsylvania, Forente stater, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19114
    - Jefferson Torresdale Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - UPMC Hillman Cancer Center
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC-Presbyterian Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forente stater, 15236
    - UPMC Jefferson Regional Radiation Oncology
  - Pittsburgh, Pennsylvania, Forente stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottsville, Pennsylvania, Forente stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Scranton, Pennsylvania, Forente stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Seneca, Pennsylvania, Forente stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forente stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Upland, Pennsylvania, Forente stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - Washington, Pennsylvania, Forente stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Chester, Pennsylvania, Forente stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forente stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forente stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forente stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Pawtucket, Rhode Island, Forente stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forente stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forente stater, 02906
    - Miriam Hospital
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Cancer Center
  - Boiling Springs, South Carolina, Forente stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forente stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forente stater, 29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston, South Carolina, Forente stater, 29414
    - Bon Secours Saint Francis Hospital
  - Charleston, South Carolina, Forente stater, 29403
    - Charleston Oncology - Roper
  - Charleston, South Carolina, Forente stater, 29414
    - Charleston Oncology - Saint Francis
  - Charleston, South Carolina, Forente stater, 29414
    - Lowcountry Oncology Associates - West Ashley
  - Easley, South Carolina, Forente stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Regional Medical Center
  - Gaffney, South Carolina, Forente stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forente stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forente stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forente stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forente stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29601
    - Greenville Health System Cancer Institute-Andrews
  - Greer, South Carolina, Forente stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Forente stater, 29651
    - Gibbs Cancer Center-Pelham
  - Lancaster, South Carolina, Forente stater, 29720
    - Carolina Blood and Cancer Care Associates PA-Lancaster
  - Mt. Pleasant, South Carolina, Forente stater, 29464
    - Lowcountry Oncology Associates - Mount Pleasant
  - Rock Hill, South Carolina, Forente stater, 29732
    - Carolina Blood and Cancer Care Associates PA
  - Seneca, South Carolina, Forente stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Medical Center
  - Union, South Carolina, Forente stater, 29379
    - SMC Center for Hematology Oncology Union
  - West Columbia, South Carolina, Forente stater, 29169
    - Lexington Health
- South Dakota
  - Rapid City, South Dakota, Forente stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Medical Associates Oncology and Hematology-Bristol
  - Bristol, Tennessee, Forente stater, 37620
    - Bristol Regional Medical Center
  - Chattanooga, Tennessee, Forente stater, 37404
    - Memorial Hospital
  - Chattanooga, Tennessee, Forente stater, 37403
    - Erlanger Medical Center
  - Hixson, Tennessee, Forente stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Kingsport, Tennessee, Forente stater, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Ooltewah, Tennessee, Forente stater, 37363
    - Memorial GYN Plus
- Texas
  - Amarillo, Texas, Forente stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Dallas, Texas, Forente stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forente stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - San Antonio, Texas, Forente stater, 78229
    - University Hospital
  - San Antonio, Texas, Forente stater, 78229
    - University of Texas Health Science Center at San Antonio
- Vermont
  - Bennington, Vermont, Forente stater, 05201
    - Southwestern Vermont Medical Center
  - Berlin Corners, Vermont, Forente stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forente stater, 05405
    - University of Vermont and State Agricultural College
  - White River Junction, Vermont, Forente stater, 05009
    - White River Junction Veteran Administration Medical Center
- Virginia
  - Charlottesville, Virginia, Forente stater, 22908
    - University of Virginia Cancer Center
  - Fredericksburg, Virginia, Forente stater, 22401
    - Fredericksburg Oncology Inc
  - Fredericksburg, Virginia, Forente stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Hampton, Virginia, Forente stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forente stater, 24501
    - Centra Alan B Pearson Regional Cancer Center
  - Norton, Virginia, Forente stater, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, Forente stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forente stater, 23298
    - VCU Massey Comprehensive Cancer Center
  - South Hill, Virginia, Forente stater, 23970
    - VCU Community Memorial Health Center
  - Winchester, Virginia, Forente stater, 22601
    - Shenandoah Oncology PC
- Washington
  - Aberdeen, Washington, Forente stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Anacortes, Washington, Forente stater, 98221
    - Cancer Care Center at Island Hospital
  - Bellevue, Washington, Forente stater, 98005
    - Swedish Cancer Institute-Eastside Oncology Hematology
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, Forente stater, 98166
    - Saint Anne Hospital
  - Centralia, Washington, Forente stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forente stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forente stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forente stater, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Lacey, Washington, Forente stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forente stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forente stater, 98632
    - PeaceHealth Saint John Medical Center
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Seattle, Washington, Forente stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98104
    - Pacific Gynecology Specialists
  - Shelton, Washington, Forente stater, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, Forente stater, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane Valley, Washington, Forente stater, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Forente stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forente stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forente stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forente stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forente stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forente stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forente stater, 25304
    - Vandalia Health/CAMC Institute for Academic Medicine
  - Huntington, West Virginia, Forente stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forente stater, 25702
    - Saint Mary's Medical Center
  - Martinsburg, West Virginia, Forente stater, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Forente stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forente stater, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forente stater, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forente stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forente stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac, Wisconsin, Forente stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forente stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forente stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forente stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forente stater, 54301
    - Bellin Memorial Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forente stater, 54601
    - Gundersen Lutheran Medical Center
  - Ladysmith, Wisconsin, Forente stater, 54848
    - Marshfield Medical Center - Ladysmith
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forente stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Medical Center - Minocqua
  - Mukwonago, Wisconsin, Forente stater, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forente stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53406
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Saint Mary's Hospital
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forente stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Aspirus Cancer Care - Stevens Point
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forente stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forente stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Forente stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Forente stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forente stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forente stater, 82609
    - Rocky Mountain Oncology
  - Cheyenne, Wyoming, Forente stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forente stater, 82414
    - Big Horn Basin Cancer Center
  - Cody, Wyoming, Forente stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

65 år og eldre (Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

PRE-REGISTRATION (STEP 0)
All patients are REQUIRED to be pre-registered to A041202 in order to submit peripheral blood to the Alliance Hematologic Malignancy Biorepository (HEME) for central Zap-70 methylation. This specimen submission is mandatory prior to registration as results will be used for stratification
REGISTRATION (STEP 1)
Patients must be diagnosed with CLL in accordance with International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 criteria that includes all of the following:
- >= 5 x 10^9 B lymphocytes (5000/uL) in the peripheral blood
- On morphologic review, the leukemic cells must be small mature lymphocytes, and prolymphocytes must not exceed 55% of the blood lymphocytes
- CLL cells on immunophenotype (performed locally) must reveal a clonal B-cell population, which express the B cell surface markers of CD19 and CD20, as well as the T-cell antigen CD5; patients with bright surface immunoglobulin expression or lack of CD23 expression in > 10% of cells must lack t(11;14) translocation by interphase cytogenetics
Patients must be intermediate or high-risk Rai stage CLL
- Intermediate risk (formerly Rai stage I/II) is defined by lymphocytosis plus enlarged lymph nodes at any site, with or without hepatomegaly or splenomegaly
- High risk (formerly Rai stage III/IV) is defined by lymphocytosis with or without enlarged nodes and spleen plus disease-related anemia (hemoglobin < 11 g/dL) or thrombocytopenia (platelet count < 100 x 10^9/L) that is not attributable to autoimmune hemolytic anemia or thrombocytopenia
Patients must meet criteria for treatment as defined by IWCLL 2008 guidelines which includes at least one of the following criteria:
- Evidence of marrow failure as manifested by the development or worsening of anemia or thrombocytopenia (not attributable to autoimmune hemolytic anemia or thrombocytopenia)
- Massive (>= 6 cm below the costal margin), progressive or symptomatic splenomegaly
- Massive nodes (>= 10 cm) or progressive or symptomatic lymphadenopathy
- Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard therapy
- Constitutional symptoms, which include any of the following:
  - Unintentional weight loss of 10% or more within 6 months
  - Significant fatigue
  - Fevers > 100.5 degrees F for 2 weeks or more without evidence of infection
  - Night sweats > 1 month without evidence of infection
Prior treatment
- Patients must not have had prior therapy for CLL (except palliative steroids or treatment of autoimmune complications of CLL with rituximab or steroids)
- Treatment with rituximab and/or high dose corticosteroids for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment; palliative steroids must be at a dose not higher than 20 mg/day of prednisone or equivalent corticosteroid at the time of registration
Age >= 65 years
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
Patients with active hepatitis B defined by hepatitis B surface antigen positivity or core antibody positivity in the presence of hepatitis B DNA are not eligible for this study; patients with a positive hepatitis B core antibody but with negative hepatitis B DNA may participate, but must have hepatitis serologies and hepatitis B DNA monitored periodically by the treating physician
- Intravenous immunoglobulin (IVIG) can cause a false positive hepatitis B serology; if patients receiving routine IVIG have core antibody or surface antigen positivity without evidence of active viremia (negative hepatitis B DNA) they may still participate in the study, but should have hepatitis serologies and hepatitis B DNA monitored periodically by the treating physician
Patients must not be receiving active systemic anticoagulation with heparin or warfarin; patients must be off warfarin therapy for at least 30 days prior to enrollment
Patients with class III or class IV heart failure by New York Heart Association, those with unstable angina, and those with uncontrolled arrhythmia are not eligible
Patients who have had a myocardial infarction, intracranial bleed, or stroke within the past 6 months are not eligible
Patients with known human immunodeficiency virus (HIV) are eligible if their CD4 count is >= 350 cells/mm^3 and if they are not taking prohibited CYP-interacting medications
Patients must not have any history of Richter's transformation or prolymphocytic leukemia (prolymphocytes in blood > 55%)
Patients must not require more than 20 mg prednisone or equivalent corticosteroid daily
Patients must not have uncontrolled active systemic infection requiring intravenous antibiotics
Patients must not have continued requirement for therapy with a strong cytochrome P450 3A4/5 (CYP3A4/5) inhibitor or inducer
Patients must not have a known allergy to mannitol
Patients must not have prior significant hypersensitivity to rituximab (not including infusion reactions)
Patients may not have had major surgery within 10 days of enrollment, or minor surgery within 7 days of enrollment; examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint; the decision about whether a surgery is major or minor can be made at the discretion of the treating physician
Absolute neutrophil count (ANC) >= 1,000/uL unless due to bone marrow involvement
Aspartate aminotransferase (AST) or alanine aminotransferase (AST) =< 2.5 x upper limits of normal except if due to disease infiltration of the liver
Bilirubin =< 1.5 x upper limits of normal (unless due to liver involvement, hemolysis, or Gilbert's disease)
Creatinine clearance >= 40 mL/min
- To be calculated by modified Cockcroft-Gault formula
Platelet count (untransfused) >= 30,000/uL

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Crossover-oppdrag
Masking: Ingen (Open Label)

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Aktiv komparator: Arm I (rituximab, bendamustine hydrochloride) Patients receive rituximab IV on day 1 (day 0 course 1) and bendamustine hydrochloride IV over 30 minutes on days 1-2. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients experiencing disease progression may crossover to Arm II. Additionally, patients undergo bone marrow aspiration and biopsy, blood sample collection, and CT throughout the study.	Annen: Laboratory Biomarker Analysis Correlative studies Annen: Quality-of-Life Assessment Ancillary studies Andre navn: Livskvalitetsvurdering Fremgangsmåte: Biospecimen Collection Undergo blood sample collection Andre navn: Biologisk prøvesamling Bioprøve samlet Prøvesamling Biologisk: Rituximab Given IV Andre navn: Rituxan MabThera ABP 798 BI 695500 C2B8 monoklonalt antistoff Kimerisk anti-CD20 antistoff CT-P10 IDEC-102 IDEC-C2B8 IDEC-C2B8 monoklonalt antistoff Monoklonalt antistoff IDEC-C2B8 PF-05280586 Riabni Rituximab ABBS Rituximab ARRX Rituximab Biosimilar ABP 798 Rituximab Biosimilar BI 695500 Rituximab Biosimilar CT-P10 Rituximab Biosimilar GB241 Rituximab Biosimilar IBI301 Rituximab Biosimilar JHL1101 Rituximab Biosimilar PF-05280586 Rituximab Biosimilar RTXM83 Rituximab Biosimilar SAIT101 Rituximab Biosimilar SIBP-02 rituximab biosimilar TQB2303 Rituximab PVVR Rituximab-arrx Rituximab-pvvr RTXM83 Ruxience Truxima Rixathon Ikgdar Mabtas Rituximab-abbs BI-695500 BI695500 Blitzima IDEC 102 IDEC102 PF 05280586 PF05280586 Ritemvia Rituximab-blit Rituximab-rite Rituximab-rixa Rituximab-rixi Riximyo RTXM 83 RTXM-83 ABP-798 ABP798 CT P10 CTP10 GP 2013 GP-2013 GP2013 Rituximab Biosimilar GP2013 Fremgangsmåte: Computed Tomography Undergo CT Andre navn: CT KATT CAT-skanning Beregnet aksial tomografi Datastyrt aksialtomografi Datastyrt tomografi CT skann tomografi Datastyrt aksial tomografi (prosedyre) Datastyrt tomografi (CT) skanning Diagnostisk CAT -skanning Diagnostisk CAT -skannertype Legemiddel: Bendamustine Hydrochloride Given IV Andre navn: Treanda Bendeka CEP-18083 Bendamustin hydroklorid Cytostasan hydroklorid Levact Ribomustin SyB L-0501 Treakisym Belrapzo CEP 18083 CEP18083 VIVIMUSTA Fremgangsmåte: Bone Marrow Aspiration Undergo bone marrow aspiration and biopsy Fremgangsmåte: Bone Marrow Biopsy Undergo bone marrow aspiration and biopsy Andre navn: Biopsi av benmarg Biopsi, benmarg
Eksperimentell: Arm II (ibrutinib) Patients receive ibrutinib PO daily. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo bone marrow aspiration and biopsy, blood sample collection, and CT throughout the study.	Annen: Laboratory Biomarker Analysis Correlative studies Annen: Quality-of-Life Assessment Ancillary studies Andre navn: Livskvalitetsvurdering Fremgangsmåte: Biospecimen Collection Undergo blood sample collection Andre navn: Biologisk prøvesamling Bioprøve samlet Prøvesamling Fremgangsmåte: Computed Tomography Undergo CT Andre navn: CT KATT CAT-skanning Beregnet aksial tomografi Datastyrt aksialtomografi Datastyrt tomografi CT skann tomografi Datastyrt aksial tomografi (prosedyre) Datastyrt tomografi (CT) skanning Diagnostisk CAT -skanning Diagnostisk CAT -skannertype Fremgangsmåte: Bone Marrow Aspiration Undergo bone marrow aspiration and biopsy Fremgangsmåte: Bone Marrow Biopsy Undergo bone marrow aspiration and biopsy Andre navn: Biopsi av benmarg Biopsi, benmarg Legemiddel: Ibrutinib Given PO Andre navn: PCI-32765 Imbruvica BTK-hemmer PCI-32765 CRA-032765 PCI32765 CRA 032765 CRA032765 PCI 32765
Eksperimentell: Arm III (ibrutinib, rituximab) Patients receive ibrutinib as in Arm II. Patients receive rituximab IV on days 1, 8, 15, and 22 of course 2 and on day 1 of courses 3-6. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo bone marrow aspiration and biopsy, blood sample collection, and CT throughout the study.	Annen: Laboratory Biomarker Analysis Correlative studies Annen: Quality-of-Life Assessment Ancillary studies Andre navn: Livskvalitetsvurdering Fremgangsmåte: Biospecimen Collection Undergo blood sample collection Andre navn: Biologisk prøvesamling Bioprøve samlet Prøvesamling Biologisk: Rituximab Given IV Andre navn: Rituxan MabThera ABP 798 BI 695500 C2B8 monoklonalt antistoff Kimerisk anti-CD20 antistoff CT-P10 IDEC-102 IDEC-C2B8 IDEC-C2B8 monoklonalt antistoff Monoklonalt antistoff IDEC-C2B8 PF-05280586 Riabni Rituximab ABBS Rituximab ARRX Rituximab Biosimilar ABP 798 Rituximab Biosimilar BI 695500 Rituximab Biosimilar CT-P10 Rituximab Biosimilar GB241 Rituximab Biosimilar IBI301 Rituximab Biosimilar JHL1101 Rituximab Biosimilar PF-05280586 Rituximab Biosimilar RTXM83 Rituximab Biosimilar SAIT101 Rituximab Biosimilar SIBP-02 rituximab biosimilar TQB2303 Rituximab PVVR Rituximab-arrx Rituximab-pvvr RTXM83 Ruxience Truxima Rixathon Ikgdar Mabtas Rituximab-abbs BI-695500 BI695500 Blitzima IDEC 102 IDEC102 PF 05280586 PF05280586 Ritemvia Rituximab-blit Rituximab-rite Rituximab-rixa Rituximab-rixi Riximyo RTXM 83 RTXM-83 ABP-798 ABP798 CT P10 CTP10 GP 2013 GP-2013 GP2013 Rituximab Biosimilar GP2013 Fremgangsmåte: Computed Tomography Undergo CT Andre navn: CT KATT CAT-skanning Beregnet aksial tomografi Datastyrt aksialtomografi Datastyrt tomografi CT skann tomografi Datastyrt aksial tomografi (prosedyre) Datastyrt tomografi (CT) skanning Diagnostisk CAT -skanning Diagnostisk CAT -skannertype Fremgangsmåte: Bone Marrow Aspiration Undergo bone marrow aspiration and biopsy Fremgangsmåte: Bone Marrow Biopsy Undergo bone marrow aspiration and biopsy Andre navn: Biopsi av benmarg Biopsi, benmarg Legemiddel: Ibrutinib Given PO Andre navn: PCI-32765 Imbruvica BTK-hemmer PCI-32765 CRA-032765 PCI32765 CRA 032765 CRA032765 PCI 32765

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Progression Free Survival (PFS) Tidsramme: Time from study entry to the time of documented disease progression or death. The analysis was event driven, performed at 2.5 years after the last patient enrolled;up to 4 years.	The Kaplan-Meier method will be used to estimate the progression free survival distributions for each arm, with median estimates provided. Progression is defined as any one of the following: an increase in number of blood lymphocytes by >= 50% with >= 5000 B lymphocytes/mL in patients on Arm A or those on Arms 2 or 3 no longer receiving ibrutinib, >= 50% increase in the products of at least 2 lymph nodes on 2 consecutive determination 2 weeks apart, >= 50% increase in the size of the liver/spleen, transformation to a more aggressive histology, progression of any cytopenia (i.e. decrease of Hb levels > 2g/dL). Progression free survival time will be the time to either progression or death whichever occurs first.	Time from study entry to the time of documented disease progression or death. The analysis was event driven, performed at 2.5 years after the last patient enrolled;up to 4 years.

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Progression Free Survival (PFS) Rate at 2 Years Tidsramme: Time from study entry to the time of documented disease progression or death, assessed up to 2 years	The Kaplan-Meier method will be used to estimate the rate of progression free survival at 2 years in each treatment arm. Progression is defined as any one of the following: an increase in number of blood lymphocytes by >= 50%, >= 50% increase in the products of at least 2 lymph nodes on 2 consecutive determination 2 weeks apart, >= 50% increase in the size of the liver/spleen, transformation to a more aggressive histology, progression of any cytopenia (i.e. decrease of Hb levels > 2g/dL). Progression free survival time will be the time to either progression or death whichever occurs first.	Time from study entry to the time of documented disease progression or death, assessed up to 2 years
Overall Survival (OS) at 2 Years Tidsramme: From the date of registration to the date of death, assessed up to 2 years	The Kaplan-Meier method will be used to estimate the rate of overall survival at 2 years in each treatment arm. OS will be measured from the date of registration to the date of the event (i.e., death) or the date of last follow-up to evaluate that event. Patients who are event-free at their last follow-up evaluation will be censored at that time point.	From the date of registration to the date of death, assessed up to 2 years
Duration of Response (DOR) (Complete Response [CR], CCR, Nodular Partial Response [nPR], Partial Response [PR], and PRL) Tidsramme: From the date of first response until progression or death, performed at 2.5 years after the last patient enrolled; up to 4 years.	The Kaplan-Meier method will be used to estimate median DOR. DOR is the time from first objective status to progression or death. CR requires all of the following: absence of lymphadenopathy > 1.5 cm on physical exam/CT scan, no hepatomegaly/splenomegaly on physical exam, no clonal B-cells in the blood, Normal CBC, bone marrow aspirate & biopsy must be normocellular for age. PR requires >= 50% decrease in peripheral lymphocyte count from pre-treatment value, >= 50% reduction in lymphadenopathy, and/or ≥ 50% reduction in splenomegaly/hepatomegaly. CR with exception of having bone marrow lymphoid CLL nodules will be considered a nodular PR (nPR). CR with exception of not having a bone marrow biopsy performed will be considered a clinical CR (CCR). PR with the exception of having less than a 50% reduction in peripheral lymphocyte count will be considered a PR except persistent lymphocytosis (PRL).	From the date of first response until progression or death, performed at 2.5 years after the last patient enrolled; up to 4 years.
Percentage of Patients Achieving Any Response to Treatment (Overall Response Rate [ORR] [Complete Response [CR], CCR, Nodular Partial Response [nPR], Partial Response [PR], and PRL]) Tidsramme: Performed at 2.5 years after the last patient enrolled;up to 4 years.	Complete response (CR) requires all of the following: absence of lymphadenopathy >1.5 cm on physical exam/CT scan, no hepatomegaly/splenomegaly on physical exam, no clonal B-cells in the blood, Normal CBC, bone marrow aspirate & biopsy must be normocellular for age. Partial response (PR) requires >= 50% decrease in peripheral lymphocyte count from pre-treatment value, >= 50% reduction in lymphadenopathy, and/or ≥ 50% reduction in splenomegaly/hepatomegaly. CR with exception of having bone marrow lymphoid CLL nodules will be considered a nodular PR (nPR). CR with exception of not having a bone marrow biopsy performed will be considered a clinical CR (CCR). PR with the exception of having less than a 50% reduction in peripheral lymphocyte count will be considered a PR except persistent lymphocytosis (PRL).Overall response rate and corresponding exact binomial 95% CI provided.	Performed at 2.5 years after the last patient enrolled;up to 4 years.
Percentage of Patients Achieving a Biopsy-proven Complete Response (CR) Tidsramme: Performed at 2.5 years after the last patient enrolled; up to 4 years.	Complete response (CR) requires all of the following: absence of lymphadenopathy > 1.5 cm on physical exam/CT scan, no hepatomegaly or splenomegaly on physical exam, no clonal B-cells in the blood, Normal CBC, bone marrow aspirate and biopsy must be normocellular for age. Complete response rate and corresponding exact binomial 95% confidence intervals provided.	Performed at 2.5 years after the last patient enrolled; up to 4 years.
Percentage of Patients Achieving Complete (CR and CCR) or Nodular Partial Response (nPR) Tidsramme: Performed at 2.5 years after the last patient enrolled; up to 4 years.	Complete response (CR) requires all of the following: absence of lymphadenopathy > 1.5 cm on physical exam/CT scan, no hepatomegaly or splenomegaly on physical exam, no clonal B-cells in the blood, Normal CBC, bone marrow aspirate and biopsy must be normocellular for age. CR with exception of having bone marrow lymphoid CLL nodules will be considered a nodular PR (nPR). CR with exception of not having a bone marrow biopsy performed will be considered a clinical CR (CCR). Response rate and corresponding exact binomial 95% confidence intervals provided.	Performed at 2.5 years after the last patient enrolled; up to 4 years.
Percentage of Patients Who Attain Minimal Residual Disease (MRD) Negative Status Tidsramme: Cycle 9 Day 1 Evaluation	Estimated using the number of patients who achieve minimal residual disease divided by the total number randomized to that treatment arm. Corresponding exact binomial 95% confidence intervals for MRD rates will be calculated.	Cycle 9 Day 1 Evaluation
The Rate of Grade 3, 4, or 5 Treatment-related Non-hematologic Adverse Events (Toxicities) Tidsramme: Performed at 2.5 years after the last patient enrolled; up to 4 years.	The rate of grade 3, 4, or 5 treatment-related non-hematologic adverse events (toxicities) by arm; excludes adverse events occurring post-crossover for patients in Arm A	Performed at 2.5 years after the last patient enrolled; up to 4 years.

Andre resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Geriatric Functional Status (Optional) Tidsramme: Performed at 2.5 years after the last patient enrolled	Assessed using the Older Americans' Resources and Services Multidimensional Functional Assessment Questionnaire, Activities of Daily Living, Medical Outcomes Study physical functioning, Karnofsky performance status rated by a health care professional, Karnofsky performance status rated by the patient, timed "Up and Go", and number of falls in the last six months.	Performed at 2.5 years after the last patient enrolled

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

National Cancer Institute (NCI)

Etterforskere

Hovedetterforsker: Jennifer A Woyach, Alliance for Clinical Trials in Oncology

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

<p>Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.</p>

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

15. januar 2014

Primær fullføring (Faktiske)

7. august 2018

Studiet fullført (Antatt)

24. juni 2027

Datoer for studieregistrering

Først innsendt

24. juni 2013

Først innsendt som oppfylte QC-kriteriene

24. juni 2013

Først lagt ut (Antatt)

26. juni 2013

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

22. oktober 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

21. oktober 2026

Sist bekreftet

1. juni 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

NCI-2013-01220
U10CA180821 (U.S. NIH-stipend/kontrakt)
U10CA031946 (U.S. NIH-stipend/kontrakt)
NCI-2013-01220 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
ALLIANCE A041202
A041202 (Annen identifikator: CTEP)
K23CA178183 (U.S. NIH-stipend/kontrakt)
R01CA183444 (U.S. NIH-stipend/kontrakt)
A041202 (Annen identifikator: Alliance for Clinical Trials in Oncology)

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Rituximab og Bendamustine Hydrochloride, Rituximab og Ibrutinib, eller Ibrutinib alene i behandling av eldre pasienter med tidligere ubehandlet kronisk lymfatisk leukemi

En randomisert fase III-studie av Bendamustine Plus Rituximab versus Ibrutinib Plus Rituximab Versus Ibrutinib alene hos ubehandlede eldre pasienter (>/= 65 år) med kronisk lymfatisk leukemi (KLL)

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Kjønn som er kvalifisert for studier

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Faktiske)

Studiet fullført (Antatt)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Antatt)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre