Study of the Preservation of the Left Colic Artery on Rectum Cancer Surgery (POTLCAORCS)
28. april 2016 oppdatert av: Jian Suo
Affection on Anastomotic Blood Flow and the Lymph Nodes Dissection Between Division at the Root of the Inferior Mesenteric Artery and Preserving the Left Colic Artery in Rectum Cancer Surgery
To evaluate the influence to the blood supply of the anastomosis and the harvest of the No. 253 lymph nodes in different surgical methods--- preserving the left colic artery (LCA) and resect the No. 253 lymph node specifically in the radical resection of rectal carcinoma or dividing at the root of the inferior mesenteric artery (IMA) in the radical resection of rectal carcinoma.
Studieoversikt
Status
Fullført
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Methods: The patients who got rectal carcinoma are divided into two groups.
Both groups will receive the radical resection of rectal carcinoma.
We preserve the left colic artery and resect the No. 253 lymph node specifically in Group A and divide at the root of the inferior mesenteric artery in Group B, We insert a trocar into the arterial arcade at the proximal site of the anastomosis and measure the blood pressure of the arterial arcade in the operation, which can reflect the blood supply of the anastomosis.
Besides, We will measure the length of the colon from the anastomosis to the level of the root of the IMA.
Expecting Results：The blood pressure of the arterial arcade in Group A will be higher than that in Group B. And the patients in Group A will have less chance to get anastomotic fistula.
Expecting Conclusions: Preserving the LCA and resecting the No. 253 lymph node specifically in the radical resection of rectal carcinoma can improve the blood supply of the anastomosis and decrease the incidence of anastomotic fistula, and won't affect the harvest of the No. 253 lymph node.
Studietype
Intervensjonell
Registrering (Faktiske)
57
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
-
-
Jilin
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Changchun, Jilin, Kina, 130021
- First Hospital of Jilin University
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år til 85 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
- Patients coming to FirstJilinU diagnosed rectum cancer by endoscopy and pathology.
- The rectum cancer is the first malignant neoplasm the patient has got.
- The cancer is solitary, and is 3cm to 20cm to the anus.
- The surgical method is limited to Dixon.
Exclusion Criteria:
- Being in the acute phase of inflammation before operation and emergency surgery.
- Patients receiving steroid medication or preoperative radiotherapy。
- Discovering macrometastasis before or in the operation.
- The rectum cancer that can't be radical resected.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
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Eksperimentell: preserving the left colic artery
We preserve the left colic artery and resect the No. 253 lymph node during the rectal surgery.
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The root of the inferior mesenteric artery(IMA) was carefully dissected and the artery wall was exposed all the way to the bifurcation of the left colic artery(LCA) and the superior rectal artery (SRA), exposing the LCA from its root until the inferior mesenteric vein (IMV) was recognized.
Subsequently, dissection was continued along the IMV up to the level of the root of the IMA.
Then the sigmoid mesentery was transected from the root of the IMA to the IMV, and the IMV and the root of the SRA were ligated.
Finally, the adipose tissue with the lymph nodes in the area surrounded by the IMA, IMV, and LCA was dissected, with preservation of the LCA .
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Eksperimentell: not preserving the left colic artery
We preserve the high ligation of the inferior mesenteric artery during the rectal surgery.
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The root of the IMA was exposed and the fatty tissue around the root of the IMA was swept in order to maximize the lymph node retrieval rate.
Subsequently, the IMA was ligated 1 cm from the aorta to avoid damaging the nerves.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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The Blood Pressure of the Arterial Arcade
Tidsramme: after ligating the inferior mesentric artery or superior rectal artery
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after ligating the inferior mesentric artery or superior rectal artery
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Distal Colon Length
Tidsramme: after digestive tract reconstruction
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after digestive tract reconstruction
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Andre resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Systemic Blood Pressure
Tidsramme: after ligating the inferior mesentric artery and measuring the blood pressure of the marginal artery of distal colon
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after ligating the inferior mesentric artery and measuring the blood pressure of the marginal artery of distal colon
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Studiestol: Jian Suo, Dr., Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. februar 2013
Primær fullføring (Faktiske)
1. september 2014
Studiet fullført (Faktiske)
1. oktober 2014
Datoer for studieregistrering
Først innsendt
25. oktober 2013
Først innsendt som oppfylte QC-kriteriene
7. november 2013
Først lagt ut (Anslag)
8. november 2013
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
6. juni 2016
Siste oppdatering sendt inn som oppfylte QC-kriteriene
28. april 2016
Sist bekreftet
1. april 2016
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- Left Colic Artery
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
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