Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery
Studieoversikt
Status
Detaljert beskrivelse
Postoperative delirium appear approximately 10-70% of patients older than 65 yrs undergoing surgery and it is strongly associated with poor surgical outcome. The clinical characteristics of postoperative delirium are fluctuating attention, visual hallucination, disorganized thought and alter sleep-wake cycles. This is quite similar to core features of α-synuclein-related cognitive disorders such as parkinson's disease dementia and dementia with lewy body. At that point, investigator thought that postoperative delirium is preclinical stage of a-synucleinopathy. In other words, a-synuclein related disorders and postoperative delirium may share an underlying neurochemical change in their pathogenesis.
investigator will recruit age 65 and older patients scheduled to perform spine surgery. The pre-operative evaluation include neurologic exam, baseline cognitive function and a-synucleinopathy related non motor symptoms through Questionnaires.
Studietype
Registrering (Faktiske)
Kontakter og plasseringer
Studiesteder
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Seou
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Seoul, Seou, Korea, Republikken, 120-752
- Department of Neurology, Yonsei University College of Medicine
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- Age 65 and older patients
- Scheduled to perform spine surgery in severance hospital
Exclusion Criteria:
- Previous delirium history
- Previous chemotherapy or radiotherapy within 1yr due to underlying cancer.
- Severe hepatic/renal dysfunction
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Observasjonsmodeller: Case-Control
- Tidsperspektiver: Potensielle
Kohorter og intervensjoner
Gruppe / Kohort |
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Delirium
occurrence of post-operative delirium
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No delirium
no presence of post-operative delirium
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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existence of anosomia
Tidsramme: A day before operation
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During 72hrs after spine surgery, investigator will observe occurrence of post-operative delirium, and analysis difference of anosmia symptoms before operation between 2 groups.
The cross-cultural smell identification test will be used for measure of anosmia.
investigator define anosmia as less than 4 score on the cross-cultural smell identification test.
This study is not interventional study, because measure of anosmia by smell kit will not develop post-operation delirium more.
(investigator will classify our patients into normosmia if the CCSIT score is 9 or higher, and hyposmia if the CCSIT score is 6 or less.
Patients whose CCSIT scores are 7 or 8 will be regarded as borderline.).
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A day before operation
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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existence of constipation
Tidsramme: A day before operation
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Questionnaire (Constipation scoring system (Agachanet al., 1996) & Rome III Questionnaire (Constipation : Yes/No)
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A day before operation
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existence of orthostatic hypotension
Tidsramme: A day before operation
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Check 3 position BP (define orthostatic hypotension - sustained reduction of systolic blood pressure of at least 20 mmHg or diastolic blood pressure of 10 mmHg within 3 min of standing, / Questionnaire (orthostatic hypotension symptom assessment & Orthostatic hypotension daily activities scale) (orthostatic hypotension: Yes/No)
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A day before operation
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existence of insomnia
Tidsramme: A day before operation
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Questionnaire (Epworth Sleepiness Scale (ESS) : total score 0-24)
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A day before operation
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existence of depression
Tidsramme: A day before operation
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Questionnaire (Beck depression inventory, total score 0-63)
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A day before operation
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existence of anxiety
Tidsramme: A day before operation
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Questionnaire (The Parkinson Anxiety Scale, total score 0-48)
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A day before operation
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existence of REM sleep behavior disorder
Tidsramme: A day before operation
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Questionnaire (RBD screening questionnaire, total score 0-13) :These questionnaires & checking 3-position BP will not effect the occurence of post-operation delirium
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A day before operation
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Samarbeidspartnere og etterforskere
Sponsor
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 4-2015-0365
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