Food Effect on Pharmacokinetic Parameters of ABX464

Inclusion Criteria:

• Healthy Caucasian male subjects, 18-55 years of age
• Body Mass Index (BMI) of 17-28 kg/m².
• Certified as healthy by a comprehensive clinical assessment (detailed medical history and complete physical examination)

• Normal vital signs after 10 minutes resting in supine position:

  90 mmHg < systolic blood pressure < 140 mmHg, 50 mmHg < diastolic blood pressure < 90 mmHg, 40 bpm < heart rate < 100 bpm.

• Normal automatic 12-lead ECG (incomplete right bundle branch block can be accepted) or judged as non clinically significant.
• Clinical laboratory tests (hematology, blood chemistry, and urinalysis) must be within normal limits or clinically acceptable to Investigator and Sponsor.
• Subjects must be willing to give written informed consent prior to study enrollment and be able to adhere to restrictions and examination schedules.

Exclusion Criteria:

• Individuals with a history of any significant medical disorder which requires a physician's care (cardiovascular, pulmonary, gastro-intestinal, hepatic, renal, metabolic, hematological, neurologic, psychiatric, systemic, or infectious disease; any acute infectious disease or signs of acute illness)
• Frequent headaches and / or migraine, recurrent nausea and / or vomiting (more than twice a month).
• Presence or history of drug allergy, or allergic disease diagnosed and treated by a physician.
• Individuals who have a history of any clinically significant local or systemic infectious disease within 4 weeks prior to drug administration.
• Any individual who does not comply with the requirement that he should not have used any drugs other than paracetamol for at least 2 weeks prior to the study nor alcohol within 48 hours prior to drug administration.
• Individuals who are positive for hepatitis B virus, hepatitis C virus or HIV.
• History or presence of drug or alcohol abuse (positive urine drug screen, positive alcohol breath test).
• Smoking more than 5 cigarettes or equivalent / day, unable to stop smoking during the study.
• Excessive consumption of beverages with xanthine bases (> 4 cups or glasses / day).
• Subject who will likely be unable to eat entirely the standard high fat breakfast within the allocated time.
• Individuals who have donated blood within the preceding 3 months.
• Individuals who refuse to use an effective method of contraception from the beginning of the study and until 3 months after dosing.
• Individuals with forfeiture of freedom by an administrative or legal obligation or under guardianship