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Impact of Force Control of Hip Abductor Muscles in Healthy Adults and Individuals With Parkinson's Disease

4. mai 2026 oppdatert av: Chu-Ling Yen, Chang Gung Memorial Hospital

Impact of Force Control of Hip Abductor Muscles on Postural Control in Middle-aged and Older Adults and Individuals With Parkinson's Disease

Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. While previous studies have mainly focused on sagittal plane balance, the contribution of hip abductor muscles remains unclear, especially regarding their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations. Previous studies have mainly focused on sagittal plane balance and have identified the important roles of ankle plantar flexors and knee extensors; however, the contribution of hip abductor muscles-key muscles for frontal plane stability-remains unclear, particularly in terms of their force production and control abilities. Therefore, this study aims to investigate hip abductor muscle force production and force control, and to examine whether these factors are associated with postural control, gait, and balance performance in individuals across different ages and those with PD. Healthy young, middle-aged, and older adults will be recruited from the community, and individuals with PD will be recruited from the Department of Neurology. Healthy participants must be in good health, able to walk independently, demonstrate normal cognitive function, and provide informed consent, while those with neurological, cardiovascular, musculoskeletal, or other conditions affecting motor performance will be excluded. For individuals with PD, inclusion criteria will be a clinical diagnosis of idiopathic PD, Hoehn and Yahr stages 1 to 3, stable anti-PD medication use, and the ability to follow instructions and walk at least 10 m. Exclusion criteria will include psychiatric, immune, integumentary, or musculoskeletal disorders, neurological conditions other than PD, lower extremity pain, uncontrolled cardiovascular disease, or inability to provide informed consent. All participants will undergo a one-time assessment, including maximal voluntary isometric contraction, force steadiness, postural control, and gait performance.

Surface electromyography will be used to assess neuromuscular function, postural control will be evaluated using a force plate under multiple standing conditions, and gait parameters will be measured at both comfortable and fast walking speeds. Statistical analyses will be conducted using ANOVA to examine group differences.

Studietype

Observasjonsmessig

Registrering (Antatt)

210

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studiesteder

  • Taiwan
      • Taoyuan, Taiwan
        • Rekruttering
        • Chang Gung Memorial Hospital
        • Ta kontakt med:
      • Taoyuan, Taiwan
        • Rekruttering
        • Chang Gung University
        • Ta kontakt med:

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

  • Voksen
  • Eldre voksen

Tar imot friske frivillige

Ja

Prøvetakingsmetode

Sannsynlighetsprøve

Studiepopulasjon

This study recruits healthy elderly individuals, healthy middle-aged individuals, healthy young individuals, and individuals with PD.

Beskrivelse

Healthy people

Inclusion Criteria:

  • 20 to 39 years (young), 40 to 59 years (young), and 60-85 years (old)
  • generally in good health
  • able to walk 10 m independently
  • able to follow all instructions

Exclusion Criteria:

  • neurologic, psychiatric, immune, integumentary, and musculoskeletal diseases or disorders which might influence this study
  • any pain over the lower extremities
  • uncontrolled cardiovascular diseases
  • unable to provide informed consent.

PD

Inclusion Criteria:

  • clinical diagnosis of idiopathic PD
  • Hoehn and Yahr stages 1 to 3
  • stable anti-PD medications
  • able to walk 10 m independently
  • able to follow all instructions

Exclusion Criteria:

  • psychiatric, immune, integumentary, and musculoskeletal diseases or disorders which might influence this study
  • neurological conditions other than PD
  • any pain over the lower extremities
  • uncontrolled cardiovascular diseases
  • unable to provide informed consent.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Kohorter og intervensjoner

Gruppe / Kohort
Intervensjon / Behandling
Healthy people
General healthy adults
Annen: Age
We compare the young, middle-aged, and old groups
Annen: Parkinson's disease (PD)
We compare the healthy group and PD group.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Maximal force
Tidsramme: Baseline
The maximal force of lower extremity muscles
Baseline
Rate of torque development
Tidsramme: Baseline
The ability to rapidly generate muscle force
Baseline
Force steadiness
Tidsramme: Baseline
The ability to maintain a constant force output during a submaximal contraction
Baseline
Walking speed
Tidsramme: Baseline
The time taken by participants to walk a standardized distance
Baseline
Step Length
Tidsramme: Baseline
The linear distance between the two ankles, typically expressed in centimeter(cm).
Baseline
Cadence
Tidsramme: Baseline
The number of steps taken per minute (SPM)
Baseline
Single Support Time
Tidsramme: Baseline
The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Baseline
Double Support Time
Tidsramme: Baseline
The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
Baseline
Swing Time
Tidsramme: Baseline
The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
Baseline
Timed Up-and-Go Test
Tidsramme: Baseline
Tthe time an individual takes to stand up from a chair, walk 3 meters, turn around, walk back, and sit down.
Baseline
Four Square Step Test
Tidsramme: Baseline
Participants will be required to perform four square step test by changing directions while stepping forward, sideway, and backward over a low obstacle as fast as possible.
Baseline
Center of Pressure (COP) Velocity in Balance Tasks
Tidsramme: Baseline
The speed at which the COP moves, calculated over the duration of the balance task. Higher velocities may reflect more dynamic balance adjustments or instability. Unit：millimeter per second(mm/s)
Baseline
Center of Pressure (COP) Area in Balance Tasks
Tidsramme: Baseline
The area covered by the COP trajectory during the balance task, providing an estimate of the sway envelope. A larger area might indicate poorer balance control. Unit：square millimeter(mm^2)
Baseline

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Chang Gung Memorial Hospital

Samarbeidspartnere

Chang Gung University

Etterforskere

  • Hovedetterforsker: Chu-Ling Yen, Chang Gung University

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. august 2023

Primær fullføring (Antatt)

31. juli 2029

Studiet fullført (Antatt)

31. juli 2029

Datoer for studieregistrering

Først innsendt

25. april 2026

Først innsendt som oppfylte QC-kriteriene

1. mai 2026

Først lagt ut (Faktiske)

6. mai 2026

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

8. mai 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

4. mai 2026

Sist bekreftet

1. mai 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • 202202289A3

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

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